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Magnesium ion selective membranes

A magnesium ion and selective technology, applied in membrane technology, semi-permeable membrane separation, material inspection products, etc., can solve problems such as stability, interference drift, poor fast start time, and other parameters

Active Publication Date: 2021-02-19
RADIOMETER AS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, making membranes highly selective for iMg remains a challenge, especially in terms of achieving selectivity for magnesium ions over other cations such as calcium ions.
In addition to having limited selectivity, the magnesium ion selective membranes described in the prior art are often suboptimal in terms of stability, interference, drift and fast start-up times
Improved tuning of a membrane with respect to one of these parameters sometimes negatively affects other parameters

Method used

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Examples

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preparation example Construction

[0226] The preparation technology of membrane of the present invention

[0227] In a further aspect, the invention relates to a process for the preparation of the magnesium ion selective membranes of the invention by mixing the components in a solvent, distributing the resulting solution on the desired support, and allowing the solvent to evaporate. Any suitable solvent can be used. In one embodiment, the solvent is cyclohexanone. The support can be flexible or rigid. The support is preferably made of a non-conductive material such as silicon, polymer, printed circuit board (PCB), flexible PCB, polyethylene terephthalate (PET), polyimide (PI), ceramic, aluminum oxide, Made of glass, woodwork, glazes, etc.

[0228] Electrodes and potentiometric sensors

[0229] In a further main aspect the invention relates to an ion selective electrode comprising a magnesium ion selective membrane of the invention as described herein. Electrodes can be on the support by using thick fi...

Embodiment 1

[0243] Embodiment 1: the preparation of ion-selective membrane

[0244] A stock solution of hemimagnesium bis[4-octylphenyl]phosphate (MgOPP) was prepared by mixing MgOPP and cyclohexanone (>99.8%) at a ratio of 48.28 grams of cyclohexanone per gram of MgOPP. The compounds were mixed at room temperature and then stirred for a minimum of 8 hours at room temperature or a minimum of 4 hours at 37°C in the dark.

[0245] A membrane dispensing solution is prepared by mixing the following components:

[0246]

[0247] The compounds were mixed in vials filled with argon or nitrogen at room temperature and then stirred at room temperature for a minimum of 40 hours or at 37°C for a minimum of 16 hours in the dark. The resulting solution was used to dispense the membrane onto a poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate)-(PEDOT-) covered gold electrode on a ceramic support. The solvent is then allowed to evaporate to obtain a plasticized ion-selective membrane.

Embodiment 2

[0248] Example 2: Properties of Membranes Including Lipophilic Salts

[0249] To investigate the effect of the addition of lipophilic acid salts on membrane performance, two membranes containing phenanthroline-based ionophores and lipophilic tetraborate were prepared. The lipophilic acid salts tested were hemicalcium bis[4-octylphenyl]phosphate and hemicalcium bis[4-(1,1,3,3-tetramethylbutyl)-phenyl]phosphate.

[0250] Two films were prepared as described in Example 1, except the compositions were as follows.

[0251]

[0252]

[0253] Distribute each film onto three separate electrodes of an electrode array that also includes Ca 2+ ion selective electrode. The films were dispensed as described in Example 1, except that vanadium brass was used as the transducer material instead of PEDOT. The resulting array of ion-selective electrodes was placed into a measurement chamber in a test analyzer. The measurement chamber is in fluid contact with a reference electrode. The...

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Abstract

Magnesium ion selective electrode membranes and the preparation thereof. The membranes are rendered highly selective for magnesium ions by the addition of acidic groups to the preferably PVC membrane,either by introducing a lipophilic compound comprising an acidic group covalently linked to a C4-C18 alkyl-substituted phenyl group (e.g. bis-4-octylphenyl phosphoric acid) into the membrane comprising the magnesium selective ionophore (e.g. a neutral ionophore 1,10-phenanthroline derivative) or by covalently linking an acidic (e.g. a carboxylic) group to the ionophore (e.g. a 1,10- phenanthroline derivative).

Description

technical field [0001] The present invention relates to magnesium ion selective membranes and their preparation, electrodes and potentiometric sensors comprising such membranes and their use for determining the concentration of magnesium ions in a sample. Background technique [0002] Magnesium is a common metal in the human body and plays an important role in chemical and biochemical processes. Magnesium in the body is either bound to proteins (complexed to anions) or exists as a free ionized fraction (iMg). The iMg fraction plays several physiological roles, for example as a modulator of ion channels in nerve conduction or contraction of skeletal, cardiac or uterine muscles. A high prevalence of hypomagnesemia (11%) and hypermagnesemia (9.3%) has been found in a study among hospitalized patients (Wong et al., (1983) Am J Clin Pathol 79:348). [0003] Specific measurement of iMg is challenging and, historically, clinical laboratories have often relied on total magnesium ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/333
CPCG01N27/3335B01D71/301B01D67/0002G01N33/50
Inventor T.P.奈加德P.施奈德P.J.尼尔森T.S.汉森T.劳尔森
Owner RADIOMETER AS