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Medicine-loaded nano robot and preparation method therefor

A drug-loaded nano-robot technology, applied in the nano-field, can solve the problems of initial drug burst release and low drug encapsulation rate, and achieve the effects of reducing burst release wind, good magnetic properties, and improving drug encapsulation rate

Active Publication Date: 2021-02-23
湖南早晨纳米机器人有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, most of the reported methods for preparing magnetic drug-loaded nanorobots are still in the experimental stage, and there are problems such as initial drug release and low drug encapsulation efficiency.

Method used

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  • Medicine-loaded nano robot and preparation method therefor
  • Medicine-loaded nano robot and preparation method therefor
  • Medicine-loaded nano robot and preparation method therefor

Examples

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preparation example Construction

[0031] The invention provides a preparation method of a drug-loaded nanorobot, comprising the following steps:

[0032] a) Provided that the surface is provided with SiO 2 The base substrate of the film layer;

[0033] b) on the SiO 2 coating the gelatin solution on the film layer, and curing the gelatin solution to form the first gelatin film layer;

[0034] c) coating a magnetic material on the first gelatin film layer to form a magnetic film layer;

[0035] d) performing photoetching on the magnetic film layer to form photoetching grooves;

[0036] e) loading the drug into the photoresist groove, and then using a gelatin solution to seal the notch of the photoresist groove, and the gelatin solution is solidified to form a second gelatin film layer;

[0037] f) Under heating conditions, the fully encapsulated multilayer composite along its SiO 2 The film layer is separated from the bonding surface of the first gelatin film layer to obtain a drug-loaded nanorobot.

[00...

Embodiment 1

[0064] Prepare drug-loaded nanorobots according to the following specific process route: cleaning → magnetron sputtering SiO 2 Film layer→coating the first gelatin film layer→sputtering magnetic film layer→laser lithography→drug loading→encapsulation (coating the second gelatin film layer)→cutting→peeling→drying and sterilizing.

[0065] 1) Cleaning:

[0066] Wipe the glass substrate substrate with a size of 200mm×200mm×0.5mm with alcohol, then put it into an ultrasonic cleaner (ultrasonic power 150W), super-clean with deionized water, super-clean with alcohol, and finally put the substrate in alcohol vapor for cleaning Drying, when the substrate is taken out from the steam, because the condensed steam evaporates from the surface, the substrate substrate can be dried quickly.

[0067] 2) Magnetron sputtering SiO 2 Film layer:

[0068] Coating a layer of SiO on the substrate by vacuum magnetron sputtering 2 The substrate protective layer, vacuum magnetron sputtering coating...

Embodiment 2

[0114] Prepare drug-loaded nanorobots according to the following specific process route: cleaning → magnetron sputtering SiO 2 Film layer→coating the first gelatin film layer→sputtering magnetic film layer→laser lithography→drug loading→encapsulation (coating the second gelatin film layer)→cutting→peeling→drying and sterilizing.

[0115] 1) Cleaning:

[0116] Wipe the glass substrate substrate with a size of 200mm×200mm×0.5mm with alcohol, then put it into an ultrasonic cleaner (ultrasonic power 150W), super-clean with deionized water, super-clean with alcohol, and finally put the substrate in alcohol vapor for cleaning Drying, when the substrate is taken out from the steam, because the condensed steam evaporates from the surface, the substrate substrate can be dried quickly.

[0117] 2) Magnetron sputtering SiO 2 Film layer:

[0118] Coating a layer of SiO on the substrate by vacuum magnetron sputtering 2 The substrate protective layer, vacuum magnetron sputtering coating...

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Abstract

The invention belongs to the field of nano technologies and particularly relates to a medicine-loaded nano robot and a preparation method therefor. The preparation method provided by the invention comprises the following steps: a) providing a substrate, of which the surface is provided with a SiO2 film layer; b) coating the SiO2 film layer with liquid gelatin, and carrying out curing, so as to form a first gelatin film layer; c) plating the first gelatin film layer with a magnetic material, so as to form a magnetic film layer; d) photoetching the magnetic film layer, so as to form photoetchedgrooves; e) loading a medicine into the photoetched grooves, then, encapsulating the photoetched grooves with liquid gelatin, and carrying out curing, so as to form a second gelatin film layer; and f)separating the encapsulated multilayer composite material under heated conditions, thereby obtaining the medicine-loaded nano robot. According to the preparation method provided by the invention, through arranging the magnetic film layer in a nano robot, the nano robot can present good magnetic properties; and meanwhile, through coating openings of the photoetched grooves, medicines in the photoetched grooves can be closely encapsulated, the medicine entrapment rate of the nano robot is increased, and the risk of sudden release of the medicines is lowered.

Description

technical field [0001] The invention belongs to the field of nanotechnology, and in particular relates to a drug-loaded nanorobot and a preparation method thereof. Background technique [0002] Drug-loaded nanorobots refer to small drug-loaded robots at the nanometer level, which have very important potential applications in the field of biomedicine, such as minimally invasive surgery, targeted therapy, cell manipulation, etc. widely concerned and developed rapidly in recent years. [0003] Compared with traditional drug-loaded robots, the Reynolds coefficient of the working environment of drug-loaded nanorobots is very low, which can be regarded as moving in a very viscous, tiny, and slow environment. can be ignored. Under such conditions, if you want to drive the nano drug-loaded robot, you must continuously provide power for it. Therefore, a variety of drug-loaded nanorobot drive methods have been proposed, including self-drive (self-electrophoresis drive, self-diffusi...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K47/42A61K47/04
CPCA61K9/0097A61K47/42A61K47/02
Inventor 张伯伦杨志
Owner 湖南早晨纳米机器人有限公司
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