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Glycerol gel electrolyte-based flexible electrochemical transistor sensor, preparation method thereof and glucose detection method

A technology of glycerol gel and electrolyte, applied in scientific instruments, instruments, measuring devices, etc., can solve the problem of non-fitting of rigid devices, and achieve the effect of good fit, easy wearability, and good flexibility

Pending Publication Date: 2021-02-23
HUBEI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the deficiencies in the prior art, the present invention provides a flexible electrochemical transistor sensor based on non-volatile glycerin gel electrolyte and its detection method for glucose, which solves the non-fitting of traditional rigid devices in the state of body movement and other problems, and can achieve long-term stable detection of electrophysiological signals in a relatively dry environment

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  • Glycerol gel electrolyte-based flexible electrochemical transistor sensor, preparation method thereof and glucose detection method
  • Glycerol gel electrolyte-based flexible electrochemical transistor sensor, preparation method thereof and glucose detection method
  • Glycerol gel electrolyte-based flexible electrochemical transistor sensor, preparation method thereof and glucose detection method

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Experimental program
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Effect test

Embodiment 1

[0041] The preparation method of the flexible glucose electrochemical transistor sensor based on glycerin gel electrolyte, the specific steps are as follows:

[0042] (1) Evaporate a chromium layer and a gold layer on a flexible PET substrate by an evaporation coating method, and the gold layer covers the top of the chromium layer and serves as the source, drain and gate of the electrochemical transistor respectively; wherein, the thickness of the chromium-plated layer The thickness of the gold layer is 0.3-1nm, and the thickness of the gold layer is 30-100nm.

[0043] (2) Cover the source and drain with tape, leave the gate for functional modification, and then place it in HAuCl 4 In the suspension with a concentration of 10mM and a concentration of graphene oxide of 0.5mg / ml, use a DC power supply of 30V for constant potential electrodeposition for 20min, and obtain a nanocomposite of gold and graphene on the surface of the gate. Its SEM image Such as figure 2 shown.

[...

Embodiment 2

[0062] The preparation method of the flexible glucose electrochemical transistor sensor based on glycerin gel electrolyte, the specific steps are different from Example 1 in that: the electrodeposition time in step (2) is 10min.

[0063] The method for detecting glucose by the above-mentioned electrochemical transistor sensor, the specific process differs from that of Example 1 in that: after dropping glucose solutions of different concentrations, the test of the transfer curve is carried out successively as follows: Figure 5 As shown, the corresponding relationship between the measured glucose concentration and the current at the gate voltage of 0.5V is shown in Table 3:

[0064] table 3

[0065] C (μM) 1 5 10 50 100 500 1000 5000 10000 15000 20000 25000 ΔI DS (μA)

[0066] Taking the change value ΔI of the channel current as the ordinate, and the logarithmic value of the glucose concentration as the abscissa, the working curve of the electrochem...

Embodiment 3

[0068] The preparation method of the flexible glucose electrochemical transistor sensor based on glycerin gel electrolyte, the specific steps are different from Example 1 in that: the electrodeposition time in step (2) is 5min.

[0069] The method for detecting glucose by the above-mentioned electrochemical transistor sensor, the specific process differs from that of Example 1 in that: after dropping glucose solutions of different concentrations, the test of the transfer curve is carried out successively as follows: Figure 7 As shown, the corresponding relationship between the measured glucose concentration and the current at the gate voltage of 0.5V is shown in Table 4:

[0070] Table 4

[0071] C (μM) 1 5 10 50 100 500 1000 5000 10000 ΔI DS (μA)

[0072] Taking the change value ΔI of the channel current as the ordinate, and the logarithmic value of the glucose concentration as the abscissa, the working curve of the electrochemical transistor sensor...

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Abstract

The invention relates to a graphene electrochemical transistor sensor prepared by taking glycerin gel as an electrolyte. The graphene electrochemical transistor sensor is used for constructing a flexible wearable sensing device. According to the device, a source electrode, a drain electrode and a grid electrode are constructed on a flexible substrate PET, the three electrodes are all gold layers covering chromium layers, single-layer graphene is transferred between the source electrode and the drain electrode through a wet method to serve as a channel, and functional modification is conductedon the grid electrode through a nano-composite of co-deposited gold and graphene. The device provided by the invention provides a method for carrying out non-enzyme non-invasive detection on glucose in body fluid based on glycerin gel as an electrolyte, has relatively good long-term stability, can be better attached to tissues and organs of a human body based on unique mechanical properties, and is wearable.

Description

technical field [0001] The invention relates to a flexible electrochemical transistor based on a glycerin gel electrolyte, a preparation method thereof, and a method for detecting glucose. Specifically, glycerin gel is used as an electrolyte in combination with a flexible transistor sensor to detect physiological electrical signals. Background technique [0002] As a common chronic disease, diabetes has become a major social problem threatening people's health. Glucose is an indicator of blood sugar level in diabetic patients, so it is very important to develop a fast, convenient and accurate glucose sensor. Electrochemical transistor sensors are considered to be promising biosignal monitoring devices due to their advantages such as low operating voltage, high transconductance, good biocompatibility, and their inherent amplification effect. In recent years, due to its excellent mechanical properties, flexible wearable devices can better fit the tissues and organs of the hum...

Claims

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Application Information

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IPC IPC(8): G01N27/414
CPCG01N27/4145G01N27/4146
Inventor 常钢周瑞陶甜涂博何云斌
Owner HUBEI UNIV
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