Multilayer drug-loaded PLGA wire material, preparation method and application
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A PLGA, drug-carrying technology, applied in the field of medical materials, can solve problems such as organ dysfunction, and achieve the effects of high drug loading, controllable molding, and simple equipment
Inactive Publication Date: 2021-03-26
CHANGZHOU UNIV
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Surgical treatment can improve tissue patency to a certain extent, but postoper
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Embodiment 1
[0023] Using PLGA and mometasone furoate as raw materials, PLGA wire materials loaded with multilayer mometasone furoate were prepared. The preparation steps of this multilayer drug-loaded PLGA wire material are as follows:
[0024] (1) PLGA raw material is dissolved in methylene chloride, and preparation mass concentration is the PLGA solution of 3%;
[0025] (2) Mometasone furoate drug molecules are added to the PLGA solution obtained in (1), fully stirred to make the medicine evenly dispersed, and obtaining a mometasone furoate solution with a mass concentration of 2.5%;
[0026] (3) Soak the PLGA wire with a diameter of 0.15mm into the drug-PLGA solution obtained in (2), slowly take it out after soaking for 30s, and solidify after the solvent volatilizes to form a surface coating of mometasone furoate to obtain a monolayer of furoate. Mometasone coated PLGA wire material;
[0027] (4) Move the PLGA wire with a single-layer mometasone furoate coating obtained in step (3) ...
Embodiment 2
[0030] Using PLGA and mometasone furoate as raw materials, a PLGA mesh scaffold loaded with multilayer mometasone furoate was prepared. The preparation steps of this multilayer drug-loaded PLGA mesh scaffold material are as follows:
[0031] (1) PLGA raw material is dissolved in methylene chloride, and preparation mass concentration is the PLGA solution of 4.0%;
[0032] (2) Mometasone furoate drug molecules are added to the PLGA solution obtained in (1), fully stirred to disperse the drug evenly, and obtaining a mometasone furoate solution with a mass concentration of 2.0%;
[0033] (3) Soak the PLGA wire with a diameter of 0.15mm into the drug-PLGA solution obtained in (2), slowly take it out after soaking for 30s, and solidify after the solvent volatilizes to form a surface coating of mometasone furoate to obtain a monolayer of furoate. Mometasone coated PLGA wire material;
[0034] (4) Move the PLGA wire with a single-layer mometasone furoate coating obtained in step (3)...
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Abstract
The invention discloses a multilayer drug-loaded PLGA wire material, a preparation method and application, and belongs to the field of medical materials. The method comprises the following steps of firstly, preparing a PLGA solution; then uniformly dispersing a drug into the PLGA solution to obtain a drug-PLGA solution; soaking the formed PLGA wires into the drug-PLGA solution, taking out the soaked PLGA wires, and curing the PLGA wires to form a surface coating after a solvent is volatilized, so as to obtain PLGA wires with single-layer drug coatings; and transferring the PLGA wires into thedrug-PLGA solution again, and repeating the steps to obtain the multilayer drug-loaded PLGA wire material. The wire material is good in physical and chemical properties and biocompatibility, and due to the characteristic of multi-layer drug loading, the material has higher drug loading capacity and longer drug release period. With the multilayer drug-loaded PLGA wire as a base material, a stent material with a net structure, a tubular structure and other controllable structures can be constructed, and the stent material can be used for research of clinically constructing tissue support and repair materials such as a paranasal sinus stent, an airway stent and a urethral stent and the like.
Description
technical field [0001] The invention belongs to the field of medical materials, and relates to a multilayer drug-loaded PLGA wire material and a preparation method thereof, in particular to a method for preparing a drug-loaded PLGA wire material with good physical and chemical properties and biocompatibility. Background technique [0002] For tissues and organs such as sinuses, airways, and urethra, stenosis will affect the normal function of the tissue, thereby seriously affecting human health. Surgical treatment can improve tissue patency to a certain extent, but postoperative inflammatory response and restenosis often lead to organ dysfunction again. By implanting degradable polymer scaffold materials at the surgical site to expand and open tissue channels, and at the same time introducing corresponding drug molecules, the process of sustained drug release can help postoperative tissue repair and treatment. [0003] In view of this, we hope to prepare a degradable polyme...
Claims
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