SonoVue-based non-invasive transcranial ultrasonic blood pressure measuring device and method

Abstract

The invention discloses a SonoVue-based non-invasive transcranial ultrasonic blood pressure measuring device and method. The device comprises a skull phantom bionic module, a blood circulation pressurizing system and a pressure measuring unit; a blood vessel phantom is arranged in a skull phantom; the blood vessel phantom is connected with the blood circulation pressurizing system; a SonoVue microbubble solution is injected into the blood vessel phantom to operate instead of the blood, and the pressure of the blood vessel phantom is controlled by the blood circulation pressurization system; an arbitrary waveform generator and an ultrasonic probe are employed to emit different incident sound pressure to the skull phantom; and meanwhile, the pressure of the blood vessel phantom is controlled, then the relationship between the different incident sound pressure, a sound scattered signal of the blood vessel phantom and the pressure of the blood vessel phantom is acquired, and then the intracranial blood pressure is determined according to the relationship therebetween. Convenient intracranial pressurization and pressure measurement are realized, and the relationship between intracranial blood pressure and injection pressure rise is reflected, so that the relationship between the SonoVue subharmonic amplitude and hydrostatic pressure presents the optimal linear relationship, and thus, not only is accurate noninvasive measurement of intracranial blood pressure realized, but also the relationship between intracranial blood pressure and intracranial pressure can be studied.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a SonoVue-based non-invasive transcranial ultrasound blood pressure measurement device and method. Background technique [0002] At present, stroke has become a major disease that plagues the health of modern people, and the common cerebral artery and large blood vessel occlusion is the most common and malignant. The middle cerebral artery is an intermediate link in the closed loop of the brain. For people with normal operation of the middle cerebral artery, the blood pressure of the middle cerebral artery is basically equal to the mean arterial pressure of the whole body. When the middle cerebral artery or common internal carotid artery is narrowed or blocked, the middle cerebral artery The blood pressure is much lower than the mean arterial pressure, which shows that the monitoring of middle cerebral artery pressure can be used as a screening method for middle cerebral artery occ...

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problem that SonoVue cannot realize pressure measurement in the prior art, the present invention provides a non-invasive transcranial ultrasonic blood pressure measurement device and method based on SonoVue coated microbubbles, so that the relationship between SonoVue sub-harmonic amplitude and hydrostatic pressure Presenting the optimal linear relationship, not only to achieve accurate non-invasive measurement of intracranial blood pressure, but also to study the relationship between intracranial blood pressure and intracranial pressure

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