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Continuous sterilization method for neomycin fermentation medium

A technology of fermentation medium and sterilization method, which is applied in the field of continuous sterilization of neomycin fermentation medium, can solve the problems of small damage to medium components and incomplete sterilization, and achieve the effect of small damage

Pending Publication Date: 2021-04-13
YICHANG SANXIA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The technical problem to be solved by the present invention is to provide a continuous sterilization method for neomycin fermentation medium, which can solve the problem that the existing continuous sterilization method is prone to incomplete sterilization, and realizes Continuous sterilization, complete sterilization and greatly improved steam utilization rate, little damage to medium components

Method used

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  • Continuous sterilization method for neomycin fermentation medium
  • Continuous sterilization method for neomycin fermentation medium
  • Continuous sterilization method for neomycin fermentation medium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] A continuous sterilization method of neomycin fermentation medium, the method may further comprise the steps:

[0026] Step 1: steam injector 6 is set on the feed pipeline of preheating tank 2, in the input process that the neomycin fermentation medium in batching tank 1 is input in preheating tank 2, utilize steam injector 6 to material Carry out the first heating, and stop heating when the temperature of the material rises to 80°C;

[0027] Step 2: Add α-amylase to the preheating tank 2, the amount of α-amylase added is 0.01% of the quality of the neomycin fermentation medium in the preheating tank 2, and maintain a temperature of 80° C. in the preheating tank 2 for 30 minutes or more;

[0028] Step 3: Input the neomycin fermentation medium into the continuous elimination tower 3, and after the second high-temperature steam injection sterilization, instantly heat the neomycin fermentation medium in the continuous elimination tower 3 to 130°C;

[0029] Step 4: input ...

Embodiment 2

[0032] A continuous sterilization method of neomycin fermentation medium, the method may further comprise the steps:

[0033] Step 1: steam injector 6 is set on the feed pipeline of preheating tank 2, in the input process that the neomycin fermentation medium in batching tank 1 is input in preheating tank 2, utilize steam injector 6 to material Carry out the first heating, and stop heating when the temperature of the material rises to 90°C;

[0034] Step 2: Add α-amylase to the preheating tank 2, the amount of α-amylase added is 0.05% of the quality of the neomycin fermentation medium in the preheating tank 2, and maintain a temperature of 90°C in the preheating tank 2 for 30 minutes or more;

[0035] Step 3: Input the neomycin fermentation medium into the continuous elimination tower 3, and after the second high-temperature steam injection sterilization, instantly heat the neomycin fermentation medium in the continuous elimination tower 3 to 140°C;

[0036] Step 4: input th...

Embodiment 3

[0039] A continuous sterilization method of neomycin fermentation medium, the method may further comprise the steps:

[0040] Step 1: steam injector 6 is set on the feed pipeline of preheating tank 2, in the input process that the neomycin fermentation medium in batching tank 1 is input in preheating tank 2, utilize steam injector 6 to material Carry out the first heating, and stop heating when the temperature of the material rises to 100°C;

[0041] Step 2: Add α-amylase to the preheating tank 2, the amount of α-amylase added is 0.1% of the quality of the neomycin fermentation medium in the preheating tank 2, and maintain a temperature of 100° C. in the preheating tank 2 for 30 minutes or more;

[0042] Step 3: Input the neomycin fermentation medium into the continuous elimination tower 3, and after the second high-temperature steam injection sterilization, instantly heat the neomycin fermentation medium in the continuous elimination tower 3 to 150°C;

[0043] Step 4: input...

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Abstract

The invention discloses a continuous sterilization method for a neomycin fermentation medium. The method includes the following steps: step one, performing first heating on materials by using a steam ejector during the process of inputting the neomycin fermentation medium in a pre-heat tank; step two, adding alpha-amylase in the pre-heat tank; step three, inputting the neomycin fermentation medium in a continuous sterilization tower, and performing second high temperature steam jet sterilization; step four, inputting the neomycin fermentation medium treated by the continuous sterilization tower in a maintenance tank; step five, inputting the neomycin fermentation medium in a cooling pipe, and completing the continuous sterilization of the neomycin fermentation medium after cooling. Through the provided method, the problems of incomplete sterilization of existing continuous sterilization methods can be solved;continuous sterilization on the neomycin fermentation medium can be realized; and the method is complete in sterilization and small in damage to the components in media, and can greatly enhance the utilization rate of steam.

Description

technical field [0001] The invention relates to the technical field of biopharmaceuticals, in particular to a continuous sterilization method for a neomycin fermentation medium. Background technique [0002] The raw materials of the culture medium used in the existing domestic neomycin fermentation are mainly grain processing raw materials, especially in a wide variety of organic nitrogen sources, including peanut powder, soybean powder, yeast powder, peptone, corn steep liquor, etc., resulting in The obtained neomycin fermentation medium contains a large amount of solid matter (10%-20%). [0003] At present, the material sterilization method widely used in the food and pharmaceutical fields is the continuous sterilization method. The main method is: the prepared and preheated (60-75°C) culture medium is continuously input with a pump and heated by direct steam. The heating tower (i.e. the continuous elimination tower) makes it reach the sterilization temperature (126-132°C...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L2/07A61L2/26
CPCA61L2/07A61L2/26
Inventor 刘铭郑新曾勇李文豪王翀肖金华舒玉婷廖鹏
Owner YICHANG SANXIA PHARMA
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