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Method for preparing ellagic acid by using tara tannin

A technology of ellagic acid and reaction solution, which is applied in the fields of food technology and biology, can solve the problems of high efficiency of ellagic acid, high thermal stability, and low product purity, and achieve accelerated chemical reaction rate, accelerated oxidation reaction, and increased exposure area effect

Active Publication Date: 2021-04-13
WUFENG CHICHENG BIOTECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to solve the problems of long time consumption, low production efficiency, low product purity and poor color of ellagic acid in the actual production process of existing ellagic acid The technical problem is to provide a method for preparing, purifying, and refining ellagic acid by using tara tannin. The method of the present invention uses an aqueous solution of tara tannin as a substrate to prepare ellagic acid by using a liquid gas jet oxidation method and a solvent washing method. The present invention The method has high efficiency for preparing ellagic acid, short production time, high yield and high purity of ellagic acid product, and the prepared ellagic acid has white color and high thermal stability

Method used

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  • Method for preparing ellagic acid by using tara tannin
  • Method for preparing ellagic acid by using tara tannin
  • Method for preparing ellagic acid by using tara tannin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0102] Embodiment 1 prepares ellagic acid

[0103] 1. Prepare Tara tannin reaction solution

[0104] The accurately weighed 160g tara tannin is dissolved in 4L deionized water to make a tara tannin aqueous solution (mass volume concentration is 40g / L); then add alkaline solution (NaOH solution) to adjust the tara tannin aqueous solution pH value to 8.5 (usually 8.0-9.0); then add 42g (0.5mol) NaHCO 3 , making tara tannin reaction solution;

[0105] In the embodiment of the present invention, the concentration of the tara tannin aqueous solution is 40g / L as an example, and other concentrations of 20-50g / L are also applicable; 3 The purpose is to form a buffer system with sodium hydroxide to ensure that the pH value of the tara tannin reaction solution remains basically stable during the reaction and will not change significantly. NaHCO 3 The amount of addition is that for every 4L of tara tannin solution with a pH value of 8.5, add 12-126g (preferably 42g) NaHCO 3 Solid, s...

Embodiment 1A

[0122] Except that the alkaline solution added in step 1) "preparing the tara tannin reaction solution" is a KOH solution, and the pH value of the tara tannin aqueous solution is adjusted to 8.5, the rest are the same as in Example 1 to obtain ellagic acid Crude product (38.13 g).

[0123] The yield of crude ellagic acid was 23.83%, and the purity was 30.55%.

Embodiment 1B

[0125] Except that the alkaline solution added in step 1) "preparing the tara tannin reaction solution" is an ammonia solution, and the pH value of the tara tannin aqueous solution is adjusted to 8.5, the rest are the same as in Example 1 to obtain ellagic acid Crude product (25.55 g).

[0126] The yield of crude ellagic acid was 15.97%, and the purity was 23.18%.

[0127] Based on Example 1, 1A, 1B, the influence order of metal ions on the yield of ellagic acid crude product is Na + >K + >NH 4 + , where Na + When participating in the reaction, the yield of the crude product of ellagic acid was 46.06%, and the introduction of K + Its yield drops to 23.83%, about Na + 1 / 2 of, NH 4 + The yield of ellagic acid generated by the introduction of 15.97%. Therefore, the present invention selects Na + (NaOH) for the preparation of ellagic acid.

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Abstract

The invention discloses a method for preparing ellagic acid by using tara tannin. The method comprises the following steps: under the action of a jet pump, repeatedly mixing tara tannin reaction liquid with air, carrying out oxidation reaction to prepare ellagic acid, and also purifying or / and refining the crude ellagic acid product prepared by oxidation treatment to obtain high-purity refined ellagic acid. The ellagic acid prepared by adopting the method is high in yield and purity, the thermal stability of the ellagic acid is improved, the ellagic acid is prepared by combining a liquid-gas jet oxidation method and a solvent washing method, the ellagic acid preparation time is greatly shortened, the purity of the ellagic acid is obviously improved, the production efficiency of industrial production of the ellagic acid is remarkably improved, the method is suitable for industrial large-scale production of ellagic acid, and widens the application of ellagic acid in the fields of medicines and cosmetics.

Description

technical field [0001] The invention relates to a method for preparing natural products, in particular to a method for preparing ellagic acid by a chemical method, and the invention belongs to the fields of food technology and biotechnology. Background technique [0002] Ellagic acid (EA) is a dimeric derivative of gallic acid with the molecular formula C 14 h 6 o 8 , is a plant polyphenol flavonoid substance, which is widely found in fruits, nuts and other plant tissues, such as pomegranate, strawberry, walnut, etc. Studies at home and abroad have shown that EA has various biological activities such as anti-oxidation, anti-inflammation, antibacterial, anti-tumor, and anti-toxicity, and has potential preventive and therapeutic effects on chronic diseases such as cardiovascular and cerebrovascular diseases, diabetes, and neuropathy. The Brookings Cancer Institute of the United States stated that "ellagic acid is the only natural variety of anti-cancer products in the past ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/06B01J10/00B01J19/24
CPCC07D493/06B01J10/00B01J19/24Y02A50/30
Inventor 陈赤清张弘徐涓李坤毛业富刘义稳陈清龙张品德冯运洋
Owner WUFENG CHICHENG BIOTECH
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