Application of lactobacillus reuteri in preventing and relieving ulcerative colitis

A technology of Lactobacillus reuteri and ulcerative colitis, applied in the field of functional microorganisms, to achieve the effect of improving colonic mucosal damage, reducing relative abundance, and good tolerance
CN112646744AActive Publication Date: 2021-04-13JIANGNAN UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
JIANGNAN UNIV
Publication Date
2021-04-13

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Abstract

The invention discloses application of lactobacillus reuteri in preventing and relieving ulcerative colitis, and belongs to the technical field of functional microorganisms. Lactobacillus reuteri CCFM1135 can tolerate the gastrointestinal environment of a human body, significantly reduce the disease activity index during the ulcerative colitis, improve colon mucosal injury, reduce MPO activity, reduce the content of proinflammatory factors TNF-alpha, IL-6 and IFN-gamma in colon, up-regulate the transcription level of colon tight junction related proteins Claudin-3, ZO-1, ZO-2 and Occludin, up-regulate the transcription levels of colon antibacterial peptides Reg3g and Reg3b, improve the diversity of intestinal flora, and reduced the relative abundance of acinetobacter in excrement.
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Description

technical field

[0001] The invention relates to the application of a strain of Lactobacillus reuteri in preventing and alleviating ulcerative colitis, and belongs to the technical field of functional microorganisms. Background technique

[0002] Inflammatory bowel disease (Inflammatory bowel disease, IBD) is a recurrent gastrointestinal disease. Inflammatory bowel disease has an unknown etiology, long course of disease, easy recurrence, many complications and difficult to cure. Ulcerative colitis (UC) is a type of inflammatory bowel disease, the main clinical manifestations are chronic or subacute diarrhea, mucus pus and blood in the stool and abdominal pain. UC is a continuous inflammation of colonic mucosa and submucosa, and the disease usually starts from the rectum and spreads to the whole colon. UC began in western countries. In recent decades, with economic development, UC has also appeared in undeveloped regions such as Asia, South America and the Middle East. Now U...

Claims

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