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Bioactive peptides derived from lymphocytes and having effects of reducing blood pressure and blood sugar and application thereof

A technology of bioactive peptides and lymphocytes, applied in the direction of medical preparations, applications, biochemical equipment and methods containing active ingredients, can solve the problems of slow clearance, etc., to promote secretion, prolong action time, and promote vascular diastolic effect

Inactive Publication Date: 2021-04-20
ZHEJIANG HUITAI LIFE HEALTH TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Antihypertensive peptides of non-food origin are known for their high tissue affinity and may therefore be cleared from tissues more slowly than synthetic drugs

Method used

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  • Bioactive peptides derived from lymphocytes and having effects of reducing blood pressure and blood sugar and application thereof
  • Bioactive peptides derived from lymphocytes and having effects of reducing blood pressure and blood sugar and application thereof
  • Bioactive peptides derived from lymphocytes and having effects of reducing blood pressure and blood sugar and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment BI

[0053] Example BIOPEP predicts the biological activity of polypeptides derived from lymphocytes

[0054] 1. Analysis method:

[0055] Intralymphocyte peptide analysis using NanoHPLC-MS / MS. Samples were searched and analyzed using PEAKS X software. The mouse protein database was downloaded from the UniProt website (16992 entries). The analysis parameters are: mass tolerance of precursor ion: 10ppm, mass tolerance of secondary spectrum: 0.020u, fixed modification is Carbamidomethyl (C), variable modification is Deamidation (NQ), Oxidation (M), non-enzymatic digestion method. Through library search and analysis, the peptide sequence in the sample was obtained. About 50 biological activities are reported in the bioinformatics database BIOPEP (http: / / www.uwm.edu.pl / biochemia / index.php / en / biopep), where the total number of bioactive peptides is 4042 peptides (2020 September visit). Using "PROFILESOF POTENTIAL BIOLOGICAL ACTIVITY" in BIOPEP, input the known polypeptide sequence,...

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Abstract

The invention relates to the field of proteins, in particular to bioactive peptides derived from lymphocytes and having the effects of reducing blood pressure and blood sugar and application thereof, and the bioactive peptides comprise 20 polypeptides. Search and efficacy test are carried out through a bioinformatics database BIOPEP, and results show that the 20 polypeptides all have the functions of reducing blood pressure (ACE inhibitory activity) and reducing blood sugar (DPPIV inhibitory activity). Search results of a BIOPEP database show that the 20 polypeptides have ACE inhibitory activity and DPPIV inhibitory activity, can prolong the action time of glucagon peptide-1 and promote insulin secretion so as to reduce blood sugar, and can promote bradykinin-mediated vasodilation so as to reduce the occurrence of hypertension, so that the bioactive peptides have very important significance for developing food, health care products and medicines with the effects of reducing blood sugar and blood pressure.

Description

technical field [0001] The invention relates to the field of proteins, in particular to bioactive peptides derived from lymphocytes and having the effect of lowering blood pressure and blood sugar and applications thereof. Background technique [0002] In recent years, bioactive peptides have become a familiar term. Because of its many potential biological functions, it has attracted more and more attention and has become one of the hot spots of scientific research. At present, the beneficial effects of many bioactive peptides have also been well proven, such as anti-cancer, lowering blood pressure, antibacterial, lowering cholesterol, anti-diabetic and other properties. More than 3000 different bioactive peptides have been reported in BIOPEP, the most authoritative bioactive peptide database. [0003] At present, most studies on bioactive peptides focus on food-derived peptides, while there are few studies and reports on non-food-derived peptides. And it has been confirm...

Claims

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Application Information

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IPC IPC(8): C07K7/08C07K7/06C12N15/12A61K38/08A61K38/10A61P3/10A61P9/12A61K8/64A61Q19/00A23L33/18
Inventor 张少辉张伯宇占文静
Owner ZHEJIANG HUITAI LIFE HEALTH TECH CO LTD