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Sulforaphane-melatonin-like compound

A technology of melatonin and compounds, applied in pharmaceutical compositions for treating skin and/or mucous membrane disorders, in the field of medicine, can solve problems such as the root cause of radiodermatitis that cannot be solved

Active Publication Date: 2021-04-20
比贝婷投资股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these approaches do not address the underlying cause of radiation dermatitis and / or mucositis

Method used

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  • Sulforaphane-melatonin-like compound
  • Sulforaphane-melatonin-like compound
  • Sulforaphane-melatonin-like compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0178] Example 1: Treatment and prevention of dermatitis

[0179] Male Göttingen minipigs (mean weight 19 kg; range 18-20 kg; age 6-7 months) obtained from the Institute of Animal Breeding and Genetics of the University of Göttingen, Germany, were used in these experiments. Minipigs were provided with tap water and a commercial laboratory piglet feed from Purina, Germany (Purina Laboratory Pig Feed 5085), which contained crude protein, fat, fiber and ash, as well as calcium, phosphorus and moisture (respectively are 14.5, 4, 5, 8, 0.55, 1 and 14%). Also, no antibiotic supplements were used. All animal experiments were performed in accordance with the German Animal Welfare Act.

[0180] Suitable topical administration according to an embodiment of the invention is obtained by adding 200 mg of Carbomer (Carbomer 934P; Lubrizol, USA) to 2.5 mL of distilled water and dissolving 200 mg of 6OHM-6-HITC in 2 mL of ethanol preparations. Transfer an appropriate amount of the ethanol...

Embodiment 2

[0193] Example 2: Treatment and prevention of mucositis

[0194]In a second example illustrating an embodiment of the present invention, six-week-old ICR mice (30-40 g) obtained from the Institute of Animal Breeding and Genetics of the University of Göttingen, Germany, were used. Animals were housed in a room maintained at 22±2°C on a 12 hour light / dark cycle with lights on at 7:00 am. Mice were fed a standard rodent diet with free access to water. Also, no antibiotic supplements were used. All animal experiments were performed in accordance with the German Animal Welfare Act. Mice (n=20 per group) were anesthetized (sodium pentobarbital, 50 mg / kg body weight, intraperitoneal injection), and then irradiated. The mice only had to be irradiated at the tip of the tongue, so the rest of the body was shielded by the lead device (0.5mm thick). The tongue was taped to the outer surface of the lead device and irradiated with a single radiation dose of 20 Gy. Radiation was generat...

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Abstract

A composition comprising a compound that comprises or consists of a conjugation of 6-hydroxymelatonin and 6- methylsufinylhexyl isothiocyanate is disclosed, as well as this composition for the use as a medicament. Furthermore, this composition for the use in a method of treating and / or preventing an epithelial tissue disease and / or disorder is disclosed.

Description

[0001] field of invention [0002] The present invention relates to the field of medicines, more particularly to the field of pharmaceutical compositions for the treatment of skin and / or mucous membrane disorders. More specifically, the present invention relates to compositions for use in methods of treating and / or preventing dermatitis and / or mucositis, to related compositions, and to related compositions for use as medicaments. [0003] Background of the invention [0004] Dermatitis and / or mucositis may be caused by oxidative stress, such as that caused by exposure to ionizing radiation. For example, radiotherapy or radiotherapy (RT) is a treatment modality in which ionizing radiation is applied to control and / or kill malignant cells, for example in cancer treatment or as part of a cancer treatment strategy. Humans may also be exposed to large doses of naturally occurring ionizing radiation, such as might be encountered during space travel, or may be exposed to large doses ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D209/04A61K31/4045A61K31/26A61P17/16A61P39/06
CPCA61P39/06A61K31/4045A61P17/16A61K45/06A61K2300/00A61K47/55A61P1/04A61K31/26
Inventor J·托池J·霍芬克
Owner 比贝婷投资股份有限公司