Preparation method and application of animal bifidobacterium F1-7 and euphausia superba oil composition for improving atherosclerosis inflammation

A technology for animal bifidobacteria, atherosclerosis, applied in the direction of bifidobacteria, drug combinations, bacteria used in food preparation, etc.

Active Publication Date: 2021-04-23
中创益科(上海)生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report about the atherosclerotic inflammatory response mitigating substances combined with probiotics and krill oil

Method used

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  • Preparation method and application of animal bifidobacterium F1-7 and euphausia superba oil composition for improving atherosclerosis inflammation
  • Preparation method and application of animal bifidobacterium F1-7 and euphausia superba oil composition for improving atherosclerosis inflammation
  • Preparation method and application of animal bifidobacterium F1-7 and euphausia superba oil composition for improving atherosclerosis inflammation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1, Bifidobacterium animalis F1-7 and krill oil mixture have atherosclerosis improving effect

[0026] HE staining of cardiovascular tissue ( figure 2 ), Atherosclerosis Group Aope - / - Cardiovascular endothelial cells in mice were extensively damaged and shed, with lipid deposition, vacuolated cytoplasm of smooth muscle cells, loose and slightly stained cytoplasm, disordered arrangement of smooth muscle cells, and large plaque-like substances were clearly visible on the inner wall of blood vessels. In the krill oil group, a small amount of plaque was attached to the inner wall, and the cardiovascular intima of the mice was slightly damaged. The smooth muscle cells were arranged neatly, with hyperplasia, increased nucleus density, and some smooth muscle cells had vacuolar changes. However, in the probiotic group and the combination group of Bifidobacterium animalis F1-7 and krill oil, there was basically no plaque deposition. The intima of the cardiac arterie...

Embodiment 2

[0027] Embodiment 2, anti-inflammatory effect of bifidobacterium animal F1-7 and krill oil mixture

[0028] The level of inflammatory changes in mice with atherosclerosis was measured, and it was found that Bifidobacterium animalis F1-7, krill oil and the mixture of the two can effectively improve the serum inflammatory level of mice. Compared with AS group, Bifidobacterium animalis F1-7, krill oil and the combination of Bifidobacterium animalis F1-7 and krill oil could significantly reduce IL-1β in serum ( image 3 ) and TNF-α ( Figure 4 ), and there was no statistical difference among the groups.

[0029] TLR4 immunohistochemical staining ( Figure 5 ) showed that compared with AS in the atherosclerosis model group, Bifidobacterium animalis F1-7, krill oil and the mixture of the two groups significantly decreased the TLR4 positive area, in which the combination of Bifidobacterium animalis F1-7 and krill oil The effect is better than the other two groups. The immunohisto...

Embodiment 3

[0030] Example 3, Anti-inflammatory Mechanism of Animal Bifidobacterium F1-7 and Krill Oil Mixture

[0031] Determination of the expression of inflammatory response-related genes in the intestine ( Figure 6 ). Compared with AS group, Bifidobacterium animalis F1-7, krill oil and their mixture can significantly reduce the expression of TNF-α. Among them, the effect of Bifidobacterium animalis F1-7 and krill oil group was significantly better than that of the other two groups. After the intervention of probiotics, krill oil and the mixture, the expression of IL-1β was significantly reduced, and there was no difference among the groups. The intervention group can also effectively reduce the expression of key genes in the TLR4 / MYD88 / NF-κB pathway, thereby inhibiting the levels of downstream inflammatory factors TNF-α and IL-1β. Bifidobacterium animalis F1-7 and krill oil had no difference in the effect of regulating TLR4 and MYD88, and the combination of Bifidobacterium animali...

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Abstract

The invention belongs to the technical field of food microorganisms and biological medicines, and discloses a preparation method and an application effect of a composition for lowering lipid, resisting inflammation and improving atherosclerosis. The composition consists of animal bifidobacterium F1-7 and euphausia superba oil; A preparation method of the composition for improving atherosclerosis comprises preparation of tablets, particles and capsules of the animal bifidobacterium F1-7 and euphausia superba oil composition. The probiotic composition provided by the invention has an excellent effect of improving the inflammatory response of atherosclerosis.

Description

technical field [0001] The invention belongs to the technical field of food microorganisms, and in particular relates to a preparation method and application effect of tablets, granules and capsules composed of probiotics and krill oil for reducing blood fat, anti-inflammation and improving atherosclerosis. Background technique [0002] Atherosclerosis is closely related to the occurrence and development of cardiovascular diseases, and is accompanied by serious complications. Existing studies all believe that atherosclerosis is a complex metabolic disorder process, its occurrence and development are based on genetic and environmental factors, and are caused by the joint action of multiple risk factors. The development of atherosclerotic plaques involves abnormal inflammatory cell recruitment, foam cell formation, smooth muscle cell proliferation, extracellular matrix synthesis, reactive oxygen species production, and arterial remodeling, among others. Among these changes, i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/135A23L33/115A61K35/745A61P9/10A61K35/612
CPCA23L33/135A23L33/115A61K35/745A61K35/612A61P9/10A23V2002/00A23V2400/515A23V2200/326A23V2200/30A23V2250/18A61K2300/00Y02A50/30
Inventor 张兰威梁曦公丕民易华西刘同杰吕优优张喆
Owner 中创益科(上海)生物科技有限公司
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