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A rare earth-based nanocomposite hydrogel wound dressing and its preparation method and application

A nano-composite and hydrogel technology, applied in pharmaceutical formulations, bandages, drug delivery, etc., can solve problems such as wound healing and tissue regeneration that have not been reported before, achieve good biological effects, convenient operation, and simple preparation process Effect

Active Publication Date: 2022-02-01
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, the research of rare earth-based nanocomposite hydrogel dressings for wound healing and tissue regeneration has not been reported

Method used

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  • A rare earth-based nanocomposite hydrogel wound dressing and its preparation method and application
  • A rare earth-based nanocomposite hydrogel wound dressing and its preparation method and application
  • A rare earth-based nanocomposite hydrogel wound dressing and its preparation method and application

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preparation example Construction

[0034] A preparation method of europium oxide-based nanocomposite hydrogel wound dressing of the present invention comprises the following steps:

[0035] 1) First use hydrothermal reaction to prepare europium hydroxide nanorods, first add europium nitrate to deionized water, stir and dissolve at room temperature, then adjust pH to 8~9 with 1M sodium hydroxide, then continue stirring at room temperature for 30-60 Minutes, and then put it into an oven at 120~200 ℃ for 12-48 hours. After the reaction is finished, it is washed with water and ethanol in sequence, and then vacuum-dried to obtain europium hydroxide. Europium hydroxide was calcined at 600°C for 3-5 hours to obtain europium oxide nanorods, which were stored in a vacuum desiccator for further use.

[0036] 2) Dissolve sodium hyaluronate in MES buffer (pH=5~6) and stir to dissolve, activate with NHS and EDC, after 10~14 hours, add sodium alendronate and continue stirring for 2~3 days, of which The molar ratio of sodiu...

Embodiment 1

[0045] 1) The preparation method of europium oxide nanorods: first add europium nitrate to deionized water, stir and dissolve at room temperature, then adjust the pH to 8~9 with 1M sodium hydroxide, then continue to stir at room temperature for 30-60 minutes, and then put it in an oven React at 120°C for 12 hours. After the reaction is finished, it is washed with water and ethanol in sequence, and then vacuum-dried to obtain europium hydroxide. Calcining europium hydroxide at 600°C for 4 hours to obtain europium oxide nanorods, which were stored in a vacuum desiccator for further use;

[0046] 2) Preparation method of HA-AL polymer: dissolve 1 mmol sodium hyaluronate in MES buffer (pH=5~6) and stir to dissolve, activate with NHS and EDC, after 12 hours, add 3 mmol into Al The sodium lendronate continued to stir for 2~3 days; finally, the hyaluronic acid-alendronate sodium polymer (HA-AL) obtained by the reaction was purified for 2~3 days with a dialysis tube (10kDa). HA-AL pol...

Embodiment 2

[0056] 1) The preparation method of terbium oxide nanorods: first add terbium nitrate into deionized water, stir and dissolve at room temperature, then adjust the pH to 8~9 with 1M sodium hydroxide, then continue to stir at room temperature for 30-60 minutes, and then put Reaction in an oven at 200°C for 16 hours. After the reaction is finished, it is washed with water and ethanol in sequence, and then vacuum-dried to obtain europium hydroxide. Calcining terbium hydroxide at 600°C for 3 hours to obtain terbium oxide nanorods, which were stored in a vacuum desiccator for further use;

[0057] 2) Preparation method of HA-AL polymer: dissolve 1 mmol sodium hyaluronate in MES buffer (pH=5~6) and stir to dissolve, activate with NHS and EDC, add 4 mmol alendron after 12 hours Sodium phosphonate continued to stir for 2~3 days; finally, the hyaluronic acid-alendronate sodium polymer (HA-AL) obtained by the reaction was purified for 2~3 days with a dialysis tube (10kDa). HA-AL polyme...

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Abstract

The invention provides a rare earth-based nanocomposite hydrogel wound dressing and a preparation method and application thereof. The preparation method comprises: using hydrothermal reaction to obtain rare earth oxide nanorods after annealing treatment; dissolving sodium hyaluronate in MES buffer solution In the process, NHS and EDC are used for activation, and finally alendronate sodium is added for reaction; the reaction obtains hyaluronic acid-alendronate sodium polymer; the hyaluronic acid-alendronate sodium polymer is dispersed in PBS of F127 In the buffer solution, after being completely dispersed, rare earth oxide nanorods are added to form a nanocomposite hydrogel, that is, a rare earth-based nanocomposite hydrogel wound dressing is obtained. Rare earth-based nanocomposite hydrogel wound dressings also show good biocompatibility in vitro and in vivo, and at the same time, also have good anti-inflammatory properties. Therefore, the hydrogel dressings have good performance in wound healing and tissue regeneration. application prospects.

Description

technical field [0001] The invention belongs to the technical field of degradable biomedical materials, and in particular relates to a rare earth-based nanocomposite hydrogel wound dressing and a preparation method and application thereof. Background technique [0002] The development of highly bioactive wound dressings that can accelerate wound healing and skin regeneration is the key to clinical wound reconstruction. Currently, various biomaterials have been used, such as inorganic biomaterials, organic biomaterials, and organic-inorganic hybrid biomaterials. Inorganic biomaterials such as silicon-based bioglass, silver nanoparticles, and zinc oxide nanorods have been demonstrated to have significant potential in wound healing and tissue regeneration. Rare-earth-based nanomaterials are widely used in various biomedicines, such as bioimaging, cancer diagnosis, and cancer therapy, due to their unique optical, magnetic, and catalytic properties, whereas they are rarely used ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L26/00C08B37/08
CPCA61L26/0023A61L26/0004A61L26/0019A61L26/0061A61L26/0066A61L26/008A61L26/009C08B37/0072A61L2300/412A61L2400/12A61L2300/41A61L2300/236C08L5/08C08L71/02
Inventor 雷波罗梦
Owner XI AN JIAOTONG UNIV
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