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Lithium-loaded three-dimensional microporous sulfonated polyether-ether-ketone, preparation method and application thereof

A technology for sulfonating polyether ether ketone and polyether ether ketone, which is applied in the application field of medical biological materials, can solve the problems of general biocompatibility effect and high production cost, and achieves simple and convenient preparation method, low production cost and good application prospect. Effect

Pending Publication Date: 2021-04-23
THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these biocomposite structures cannot form a stable and durable combination with the polyether ether ketone matrix, have general effects on improving the biocompatibility of PEEK, and have relatively high production costs.

Method used

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  • Lithium-loaded three-dimensional microporous sulfonated polyether-ether-ketone, preparation method and application thereof
  • Lithium-loaded three-dimensional microporous sulfonated polyether-ether-ketone, preparation method and application thereof
  • Lithium-loaded three-dimensional microporous sulfonated polyether-ether-ketone, preparation method and application thereof

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Embodiment Construction

[0033] The present invention will be further described below in conjunction with specific examples, but the examples are only exemplary and do not constitute any limitation to the scope of the present invention. Those skilled in the art should understand that the details and forms of the technical solutions of the present invention can be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the protection scope of the present invention.

[0034] 1. Materials and methods

[0035] 1. Materials

[0036] 1.1 Reagents and experimental equipment

[0037] 1.1.1 Main Drugs and Reagents

[0038] PEEK sheets were purchased from Suzhou Aide Technology Development Co., Ltd., China; LiOH was purchased from Sigma, the United States; concentrated sulfuric acid was purchased from Suzhou Xiangshangyi Electronic Materials Co., Ltd., China; paraformaldehyde, PBS, DAB chromogen, hematoxylin, iodine R...

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Abstract

The invention discloses lithium-loaded three-dimensional microporous sulfonated polyether-ether-ketone, a preparation method and application thereof. The lithium-loaded three-dimensional microporous sulfonated polyether-ether-ketone is prepared by sulfonation and lithiation treatment, lithium ions capable of stimulating secretion of angiogenesis promoting factors and enhancing bone regeneration, cartilage generation and protection are loaded to sulfonated three-dimensional microporous sulfonated polyether-ether-ketone through a surface chemical modification technology. The preparation method disclosed by the invention is simple to operate and mild in reaction condition, and after the PEEK matrix is modified, the properties of the material are not greatly changed, and elements harmful to a human body are not introduced, so that excellent mechanical properties of the PEEK are reserved; the prepared SPEEK-Li is excellent in performance, the biocompatibility and the bone ingrowth promoting capacity are remarkably improved, and the SPEEK-Li has a good application prospect clinically.

Description

technical field [0001] The invention belongs to the technical field of application of medical biomaterials, in particular to a three-dimensional (3D) microporous sulfonated polyether ether ketone (SPEEK-Li) loaded with lithium, a preparation method and its application. Pore ​​sulfonated polyether ether ketone to promote implant-interface osseointegration. Background technique [0002] As a semi-crystalline, high-performance, non-absorbable thermoplastic material, polyetheretherketone (PEEK) has been used as an alternative to metal implants for trauma, orthopedic, and spinal surgery. Compared with metal implants, PEEK has the following advantages: ①Environmental resistance, which helps to improve corrosion resistance in the human body; ①Low elastic modulus (3-4gpa), comparable to the elasticity of human cortical bone (18gpa) The modulus is very close, which can reduce the degree of stress shielding; ③ light transmission is beneficial to evaluate new bone formation around PEE...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G8/28A61L27/18A61L27/54A61L27/56
Inventor 周军耿德春李宁柏家祥葛高然肖龙王志荣顾叶陈亮徐耀增杨惠林
Owner THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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