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Silver-loaded tannin polyphenol crosslinked polyvinyl alcohol antibacterial hydrogel and preparation method thereof

A technology of cross-linking polyvinyl alcohol and tannin polyphenols, which is applied in the fields of biomedical materials and polymer chemistry, can solve the problems that polyphenol-based hydrogels are rare and uncommon, and achieve short preparation time and adjustable performance Change, the effect of simple preparation method

Active Publication Date: 2021-05-04
WUXI NO 2 PEOPLES HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Theoretically speaking, plant polyphenols have great application potential in the field of biomedical materials, but there are few reported green biomedical materials based on plant polyphenols, especially polyphenol-based hydrogels with specific functions. is very rare

Method used

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  • Silver-loaded tannin polyphenol crosslinked polyvinyl alcohol antibacterial hydrogel and preparation method thereof
  • Silver-loaded tannin polyphenol crosslinked polyvinyl alcohol antibacterial hydrogel and preparation method thereof
  • Silver-loaded tannin polyphenol crosslinked polyvinyl alcohol antibacterial hydrogel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Add 1g of tannic acid and 0.05g of silver nitrate into a 50mL stainless steel ball milling tank, and mix them by ball milling for 10min to obtain a gray silver-loaded polyphenol hybrid, then add 2g of polyvinyl alcohol and 20mL of deionized water, and continue ball milling for 10min to obtain The gel-like product was frozen in a cold trap at -25°C for 12 hours, and then thawed at room temperature. This repeated freezing and thawing 5 times, and finally silver-loaded tannic acid cross-linked polyvinyl alcohol antibacterial hydrogel was obtained. In the past, the preparation time of silver-loaded hydrogel by solution method is often more than 10 hours, but this technology adopts ball milling method, which accelerates the coordination and reduction time between silver and polyphenols, thus greatly speeding up the preparation of silver-loaded hydrogel time.

[0032] figure 1 Schematic diagram of the structure of the silver-loaded tannic acid cross-linked polyvinyl alcohol ...

Embodiment 2

[0037] Add 1 g of tannic acid and 0.05 g of silver nitrate into a 50 mL stainless steel ball milling tank, and mix by ball milling for 30 minutes to obtain a gray silver-loaded polyphenol hybrid, then add 1 g of polyvinyl alcohol and 20 mL of deionized water, and continue ball milling for 30 minutes to obtain The gel-like product was frozen in a cold trap at -25°C for 12 hours, and then thawed at room temperature. This repeated freezing and thawing 5 times, and finally silver-loaded tannic acid cross-linked polyvinyl alcohol antibacterial hydrogel was obtained. Image 6 Photographs of the obtained samples.

[0038] Figure 5 It can be seen that when the ratio of silver-loaded tannic acid to polyvinyl alcohol is increased, the obtained hydrogel still has good elasticity and mechanical strength.

Embodiment 3

[0040] Add 1 g of ellagic acid and 0.05 g of silver nitrate into a 50 mL stainless steel ball mill jar, and mix by ball milling for 30 minutes to obtain a gray silver-loaded polyphenol hybrid, then add 2 g of polyvinyl alcohol and 20 mL of deionized water, and continue ball milling for 30 minutes to obtain The gel-like product was frozen in a cold trap at -25°C for 12 hours, and then thawed at room temperature. This repeated freezing and thawing 5 times, and finally the silver-loaded ellagic acid cross-linked polyvinyl alcohol antibacterial hydrogel was obtained.

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Abstract

The invention discloses silver-loaded tannin polyphenol cross-linked polyvinyl alcohol antibacterial hydrogel and a preparation method thereof, and belongs to the field of biomedical materials and polymer chemistry. The hydrogel is prepared from the following substances: tannin polyphenol, silver nitrate, polyvinyl alcohol and the balance of deionized water, and the antibacterial hydrogel with relatively high mechanical strength is prepared by ball milling and freezing and unfreezing methods. A characterization result shows that the hydrogel has relatively high water content, mechanical strength and high-dispersion silver nanoparticles. The preparation method has the advantages that tannin polyphenol is adopted in a hydrogel system for in-situ reduction of metal silver, introduction of other reducing agents is avoided, and in addition, a mechanical ball milling method is adopted in the preparation process, so that operation is simpler and more environmentally friendly.

Description

technical field [0001] The invention relates to a silver-loaded tannin polyphenol cross-linked polyvinyl alcohol antibacterial hydrogel and a preparation method thereof, belonging to the fields of biomedical materials and polymer chemistry. Background technique [0002] Polyvinyl alcohol hydrogel is a water-soluble polymer material commonly used in medicine. It is widely used due to its low toxicity, high elastic modulus and mechanical strength, high water absorption, and good biocompatibility. In the biomedical fields such as wound dressings, artificial organ tissues, and drug sustained-release carriers. In recent years, in order to enrich the application range of polyvinyl alcohol hydrogel materials, many researchers have focused on functional modification of hydrogels. For example, the mechanical strength and water absorption properties of PVA hydrogels can be changed by introducing some natural organic macromolecules; the antifouling properties and antibacterial propert...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L29/04C08K9/12C08K3/08
CPCC08J3/075C08J2329/04C08K9/12C08K2003/0806C08K2201/011
Inventor 邹文军武志峰徐慧艳罗莎莎冷炎石朗晨蒋平平张哲铭
Owner WUXI NO 2 PEOPLES HOSPITAL
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