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Microcapsules containing natural oil and preparation method therefor

A technology of microcapsules and natural oils, applied in the direction of microcapsule preparation, microsphere preparation, biochemical equipment and methods, etc., can solve the problems of weak strength and achieve the effect of improving mechanical properties and retention

Pending Publication Date: 2021-05-07
KOREA RES INST OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

A physical gel can be formed even without a special crosslinking agent, but it has the problem of weak strength like a hydrogel

Method used

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  • Microcapsules containing natural oil and preparation method therefor
  • Microcapsules containing natural oil and preparation method therefor
  • Microcapsules containing natural oil and preparation method therefor

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preparation example Construction

[0031] According to another embodiment of the present invention, the present invention provides a method for preparing microcapsules containing natural oil, comprising: step (a), preparing a gelatin solution containing gelatin, oil and an oily thickener; step (b), preparing natural oil polymer solution; step (c), mixing the above-mentioned gelatin solution and natural polymer solution; step (d), adjusting the pH of the mixture prepared in step (c); and step (e), cooling the conditioned pH mixture.

[0032] Specifically, the preparation method of the microcapsules of the present invention is shown in FIG. 1 .

[0033] Relative to the weight of the oil, 1% by weight to 15% by weight of the oily thickener of the above step (a) may be included, preferably, 2% by weight to 10% by weight of the oily thickener of the above step (a) may be included , more preferably, can contain 4% by weight to 6% by weight of the oily thickener of the above-mentioned step (a), most preferably, can c...

Embodiment 1

[0038] Embodiment 1. The preparation of gelatin oil capsule

[0039] 1-1. Experimental group 1

[0040] Microcapsules comprising gelatin, natural polymer and oil were prepared using the method shown in Figure 1 .

[0041]Specifically, the gelatin solution was prepared by mixing 1.5 g of gelatin (pig, 300 bloom, type A) and 50 ml of triple distilled water, and then heating the mixture to 70° C. to completely dissolve the gelatin. The natural polymer solution was prepared by mixing 1.5 g of gum arabic and 50 ml of triple distilled water, and keeping the mixture at a temperature of 70° C. to completely dissolve the gum arabic. After adding 24 g of squalane (hydrogenated poly1-decen, puresyn4) as oil to the above gelatin solution, it was stirred at a temperature of 40° C. or higher by a stirrer at a rotation speed of 100 rpm to 150 rpm for 5 minutes. After adding the above-mentioned natural polymer solution to the stirred gelatin solution, the pH is adjusted to 3.1 to 3.6 using ...

Embodiment 2

[0051] Embodiment 2. The coefficient of elasticity detection of gelatin oil capsule

[0052] The elastic modulus of the gelatin oil capsules of experimental group 1 to experimental group 4 was detected. Specifically, gelatin oil capsules were arranged between two flat plates with a distance of 1000 μm and a radius of 20 mm. The coefficient of elasticity was analyzed using a rotating rheometer (TA Instruments, AR 1500ex type) at room temperature with the pressure (strain) fixed at 0.01, and analyzed within the range of 0.01 to 5 Hz. The detection result of elastic coefficient of gelatin oil capsule is as follows: figure 2 shown.

[0053] Such as figure 2 As shown, in the preparation of gelatin oil capsules, when a part of the gum arabic was replaced with hyaluronic acid, it was confirmed that the elasticity of the gelatin oil capsules increased. In particular, it was confirmed that the elasticity of the experimental group 3 mixed with gum arabic and hyaluronic acid at a w...

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Abstract

The present invention relates to microcapsules containing natural oil and, more specifically, to microcapsules which contain gelatin, natural polymers, oil, and an oil thickener and have enhanced mechanical properties, and a preparation method therefor. The microcapsules containing natural oil according to the present invention have remarkably enhanced mechanical properties and retention properties, and when co-cultured with cells, the microcapsules provide the effect of inducing maturation of the cells, and thus can be used in various fields of microcarriers, cell cultures, and co-culture systems.

Description

technical field [0001] The present invention relates to a microcapsule containing natural oil, and more specifically, to a microcapsule containing gelatin, natural polymer, oil and an oily thickener with improved mechanical properties and a preparation method thereof. Background technique [0002] Although gelatin does not exist naturally, it can be obtained by hydrolyzing collagen, which is a protein, present in biological tissues. Nearly colorless, almost odorless and fragrance-free, it is widely used as various food additives. The molecular weight is about 35,000-40,000, and glycine, proline, hydroxyproline, and glutamic acid are its main components. As a biomaterial with outstanding biocompatibility, it is a natural polymer that is non-toxic, biodegradable in vivo, and less likely to induce antibody induction. It is used for various purposes such as artificial skin, contact lenses, and drug delivery bodies, and it is also a material that can be applied in various other...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/00
CPCB01J13/10B01J13/206C12N5/0075C12N2533/54C12N2533/70C12N2533/80B01J13/08C12N5/0657C12N2531/00
Inventor 姜善雄沈慧恩
Owner KOREA RES INST OF CHEM TECH
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