Use of micro RNAs in skin-whitening and caring product

A whitening and product technology, applied in the field of biomedicine, can solve the problem of less research

Active Publication Date: 2021-05-11
NANCHANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

A large number of literature reports show that miRNA plays an important regulatory role in the development of the body, metabolism, tumors and other diseases, but there are few studies in the field of dermatology

Method used

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  • Use of micro RNAs in skin-whitening and caring product
  • Use of micro RNAs in skin-whitening and caring product
  • Use of micro RNAs in skin-whitening and caring product

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Embodiment

[0020] The inventors found that miR-181a-5p inhibits the protein level and transcription level of the melanin synthesis-related gene MITF, thereby reducing the expression of its downstream genes (such as Tyrosinase, TRP1, TRP2) to inhibit melanin synthesis, reduce melanin content, and whiten the skin. Effect: miR-199a degrades excess melanin by promoting autophagy to reduce skin melanin content, and then play a whitening effect. The inventor also verified through follow-up experiments that the above two microRNAs can be applied to whitening skin care products and the mechanism of their efficacy. Excessive melanin and its related skin lesions such as pigmented spots and age spots.

[0021] The nucleotide sequence of miR-181a-5p is: 5'-AACAUUCAACGCUGUCGGUGAGU-3', specifically see SEQ ID NO.1; the nucleotide sequence of miR-199a is 5'-ACAGUAGUCUGCACAUUGGUUA-3', specifically see SEQ ID NO. 2.

[0022] The inventors found that both miR-181a-5p and miR-199a mimics can significantl...

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Abstract

The invention relates to the technical field of biomedicine and discloses use of micro RNAs in a skin-whitening and caring product. The micro RNAs comprise one or two of the following components: miR-181a-5p and miR-199a. The miR-181a-5p and miR-199a are firstly found and verified to respectively inhibit melanin synthesis and promote melanin degradation. As active ingredients for inhibiting melanin deposition, the miR-181a-5p and miR-199a can be applied in preparing cosmetics, have a good treatment effect on melanin deposition caused by endocrine dyscrasia or chemical substance stimulation or physical stimulation such as ultraviolet irradiation, can make skin white and bright, and can maintain a healthy, natural and bright and white state of the skin. The miR-181a-5p and the miR-199a are used as effective skin- whitening ingredients, and have characteristics of good stability, strong specificity and simple preparation method, and important practical popularization value.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to the application of microRNA in whitening and skin care products. Background technique [0002] Melanin deposition refers to the excessive deposition of abnormally increased melanin in some parts of the skin. The skin can show pigmentation changes in different ranges and depths, and then form pigmented spots, age spots, etc. Melanin deposition is a complex biochemical process. At the molecular level, the effects on skin pigmentation mainly include two aspects: the synthesis and degradation of melanin. When the skin is over-irradiated by ultraviolet rays, keratinocytes in the skin secrete α-MSH, activate the cAMP cascade reaction, and induce the expression of key genes for melanin synthesis in melanocytes, such as microphthalmia-associated transcription factor (MITF). The degradation of melanin is also another key factor in determining skin color. It has been reported that aut...

Claims

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Application Information

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IPC IPC(8): A61K8/60A61Q19/02
CPCA61K8/606A61Q19/02
Inventor 辛洪波汪晓玉管小卉
Owner NANCHANG UNIV
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