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Temperature-sensitive gel for repairing colonic mucosa

A temperature-sensitive gel and temperature-sensitive gel matrix technology, applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, digestive system, etc., can solve the problems of intolerance to dilution, weak protein stability, no antibacterial ability, etc. problem, achieve the effect of improving stability, good reproducibility, and promoting the healing of ulcer mucosa

Active Publication Date: 2021-05-11
WENZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the delivery of protein drugs by thermosensitive poloxamer hydrogels for the treatment of ulcerative colitis has defects such as intolerance to dilution, weak protein stability and no antibacterial ability.

Method used

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  • Temperature-sensitive gel for repairing colonic mucosa
  • Temperature-sensitive gel for repairing colonic mucosa
  • Temperature-sensitive gel for repairing colonic mucosa

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0041] 1. Preparation of cytokine-polyphenol nanocomposites

[0042]Polyphenol (Phol) and cell growth factor (GF) were fed as listed in Table 1, dissolved in distilled water, controlled temperature at 0-4°C, stirred gently for 0.5h to prepare cytokine-polyphenol nanocomposite substance solution. After the prepared nanocomposites were properly diluted with distilled water, the composite efficiency was determined by ultrafiltration, and the results are shown in Table 1. It can be seen from the results in Table 1 that the compounding efficiency of the nanocomposite is related to the GF / Phol ratio in the prescription. When the mass ratio of cell growth factor and polyphenol is 1:0.1-1:5, the compounding efficiency is relatively high and can reach 75%. above.

[0043] Table 1 Cell growth factor-polyphenol nanocomposite formula and compound efficiency

[0044]

[0045]

[0046] Note: EGCG: epicatechin gallic acid; TA: tannin; GF: cell growth factor; TA+EGCG: TA and EGCG mix...

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Abstract

The invention belongs to the field of repairing pharmaceutical preparations and particularly relates to temperature-sensitive gel for repairing colonic mucosa. The temperature-sensitive gel is prepared from the following raw material components: a cell growth factor, epsilon-polylysine or salt thereof, a temperature-sensitive material, first polyphenol and second polyphenol, wherein the cell growth factor and the first polyphenol form a polyphenol-cell growth factor nano-composite; the epsilon-polylysine or the salt thereof, the temperature-sensitive material and the second polyphenol form a temperature-sensitive gel matrix; and the polyphenol-cell growth factor nano-composite is encapsulated in the temperature-sensitive gel matrix. The temperature-sensitive gel provided by the invention has dilution resistance, mucosa adhesion and antibacterial capability and also can be used for improving the stability of the cell growth factor; and after the temperature-sensitive gel is poured and administrated, the cell factor can be slowly released and the healing of ulcer mucosa is promoted, so that ulcerative colitis can be efficiently treated. The temperature-sensitive gel has the advantages of simple preparation method and good repeatability and large-scale production is easy to realize.

Description

technical field [0001] The invention belongs to the field of repairing pharmaceutical preparations, and in particular relates to a temperature-sensitive gel for repairing colonic mucosa. Background technique [0002] Ulcerative colitis (UC) is a chronic disease characterized by mucosal inflammation and ulceration. The pathogenesis of UC is not very clear at present, and it is believed to be related to the damage of the colonic mucosal barrier caused by comprehensive factors such as genetics and environment. Under the attack of toxic molecules or pathogenic microorganisms in the colonic mucosa, epithelial cells undergo abnormal apoptosis, intestinal epithelial permeability increases, and antigens in the intestinal lumen are abnormally exposed to the lymphoid tissue of the lamina propria, resulting in the release of a large number of inflammatory factors, causing local immunity. inflammatory response. Disruption of epithelial integrity is closely associated with intestinal m...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61K9/06A61K9/08A61K47/34A61K47/10A61K47/22A61P1/00A61P1/04A61K31/785
CPCA61K38/1808A61K38/1825A61K31/785A61K9/06A61K9/08A61K9/0019A61K9/0024A61K47/34A61K47/10A61K47/22A61P1/00A61P1/04A61K2300/00
Inventor 徐荷林王丽芬赵应征薛鹏鹏徐佳微刘嘉懿
Owner WENZHOU MEDICAL UNIV
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