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Methods, devices, and systems for improving skin characteristics

A skin quality, skin technology, applied in the field of improving skin quality, devices and systems, can solve problems such as damage to the surrounding epidermis

Pending Publication Date: 2021-05-11
ZELTIQ AESTHETICS INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, one factor limiting the application of cryolipolysis is the possible damage to the surrounding epidermis due to overexposure to low temperatures

Method used

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  • Methods, devices, and systems for improving skin characteristics
  • Methods, devices, and systems for improving skin characteristics
  • Methods, devices, and systems for improving skin characteristics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0109] Example 1: Effect of Controlled Freezing and Lipolysis Cooling on TGF-β Expression

[0110] Commercially available CoolAdvantage Petite, available from Zeltiq Aesthetics Corporation, the assignee of the present invention TMThe treatment unit was set to a controlled cooling temperature of -11°C and applied to the human subject's skin near the target site for a treatment duration of 35 minutes.

[0111] The effect of epidermal cooling on TGF-β mRNA expression in skin and adipose layer was analyzed using Invitrogen viewRNA TM ISH assay protocol, assessed by RNA in situ hybridization (RNA-ISH) staining of formalin-fixed paraffin-embedded (FFPE) tissue samples. The probe was the human TGF-β1 gene (Thermofisher, #VA6-17264).

[0112] Three weeks after treatment, subjects showed a significant increase in TGF-β mRNA expression in fat ( Figures 1B-1D ), while the skin TGF-βmRNA level had no or minimal changes. This increase was observed both in the dermis surrounding the ...

Embodiment 2

[0113] Example 2: Effect of controlled cryolipolysis cooling on collagen expression

[0114] A CoolAdvantage Petite treatment unit set at -11°C was applied to the human subject's skin proximate to the target site for 35 minutes.

[0115] Effect of Epidermal Cooling on Collagen Expression in Skin and Fat Layers Using Invitrogen viewRNA TM ISH assay protocol, assessed by RNA-ISH staining of formalin-fixed paraffin-embedded (FFPE) tissue samples. The probe was human COL1A1 (Thermofisher, #VA6-18298).

[0116] Three weeks after treatment, subjects showed a significant increase in collagen, COL1A1 mRNA levels in subcutaneous adipose tissue (compare Figure 2A (untreated) vs. 2B (treated)). Subcutaneous adipose tissue from untreated sites showed no changes or elevated signals of COL1A1 mRNA, Figure 2A .

[0117] Upregulation of collagen mRNA is critical for new collagen synthesis (mRNA-to-protein central dogma). To determine whether collagen synthesis was indeed present due...

Embodiment 3

[0118] Example 3: Effect of controlled sub-freezing fat-melting cooling on skin thickness

[0119] A treatment unit of a superficial prototype applicator (designed to conform to the curvature of the thigh, available from Zeltiq Aesthetics, Inc.) set at -14°C was applied to the skin of 20 human subjects near the target site for 20 minutes per treatment.

[0120] The effect of epidermal cooling on skin thickness was assessed by measuring thigh skin thickness. Ultrasound was performed using 50-MHz (DermaScan, Cortex Technology), producing images representing cross-sections of the skin. The skin appears as a heterogeneous echogenic band in the center of the image. Image description, layers from left to right are: bright thin layer is ultrasound liner (thin hyperechoic layer), water-based coupling transmission gel (noticeable hypoechoic layer), skin epidermis / dermis (heterogeneous echogenic bands) and subcutaneous fat (significant hypoechoic layer). Skin thickness was measured...

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Abstract

Provided herein are systems, compositions, and methods for improving one or more skin characteristics in a subject. These systems, compositions, and methods are configured to cool the subject's skin at a target site to a degree that alters adipocyte signaling but does not produce significant destruction of subcutaneous lipid-rich cells. In some embodiments, alteration of adipocyte signaling produces an improvement in one or more skin characteristics.

Description

[0001] Cross References to Related Applications [0002] This international application claims priority from U.S. Provisional Patent Application No. 62 / 712,562, filed July 31, 2018, the entire contents of which are incorporated herein by reference in their entirety. Background technique [0003] The skin consists of the superficial layer of the epidermis and the thicker layer of the dermis just below the epidermis. The subcutaneous area, also known as the hypodermis, is located just below the dermis. This layer of subcutaneous fat stores fat and serves to anchor the dermis to the underlying muscles and bones. [0004] Cryolipolysis is a non-invasive procedure used to destroy lipid-rich cells (eg, adipocytes) in subcutaneous fat by cooling target tissue in a controlled manner to reduce fat volume and lead to more Slim and aesthetically pleasing appearance. Cold temperatures are applied to the epidermis to cool the subcutaneous layer to a target temperature for a period of ti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F7/00A61F7/10
CPCA61F7/10A61F7/007A61F2007/0075A61F2007/0056A61F2007/0052A61B90/98A61F2007/029A61F7/00
Inventor J·N·吉米内兹洛萨诺L·曾L·帕姆G·小弗兰基尼斯
Owner ZELTIQ AESTHETICS INC
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