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Bioactive ceramic scaffold for bone tissue repair and tumor treatment and preparation method thereof

A bioactive ceramic, bioactive technology, applied in tissue regeneration, prosthesis, medical science and other directions, can solve the problems of non-degradable modification, no regulatory effect, complicated operation process, etc., to achieve easy control of conditions, stable material performance, Simple preparation process

Active Publication Date: 2021-05-14
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the operation process of the surface modification of the scaffold is too complicated, and after the scaffold is degraded in the later stage, the modification on the surface cannot be degraded, and if it remains in the human body, it will cause certain damage to the human body; in addition, a single bioceramic scaffold can only regenerate bone tissue. play a role in promoting, but not regulating

Method used

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  • Bioactive ceramic scaffold for bone tissue repair and tumor treatment and preparation method thereof
  • Bioactive ceramic scaffold for bone tissue repair and tumor treatment and preparation method thereof
  • Bioactive ceramic scaffold for bone tissue repair and tumor treatment and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] (1) Ingredients and mixing: take 5g of white Ca 2 MgSi 2 o 7 Ceramic powder, 0.3g sodium alginate powder and 3.2g 20wt% F-127 solution were mixed evenly to obtain 3D printing paste.

[0057] (2) Printing: The obtained 3D printing slurry was printed with a 3D printer, and the printing parameters were as follows: the printing pressure was 300kPa, and the moving speed of the barrel was 8mm / s.

[0058] (3) Sintering: the stent was heated up to 1350°C at a rate of 2°C / min for sintering, the sintering atmosphere was air, and the holding time was 3h.

[0059] (4) Magnesium thermal reduction treatment: place the sintered bracket in a crucible boat, cover the surface of the bracket evenly with a layer of magnesium powder 1-3mm thick, and then place the crucible boat in an argon atmosphere furnace at 2°C / Min was heated up to 500°C and kept for 1h. Naturally cooled to room temperature to obtain a white feldspar stent, denoted as 500-B-AKT.

[0060] The 500-B-AKT scaffold pre...

Embodiment 2

[0062] (1) Ingredients and mixing: take 5g of white Ca 2 MgSi 2 o 7 The ceramic powder, 0.3g of sodium alginate powder and 3.2g of 20wt% F-127 solution were mixed evenly (the mixing method was manual stirring) to obtain a 3D printing slurry.

[0063](2) Printing: use the obtained 3D printing slurry to print the bracket with a 3D printer, the printing parameters are printing pressure of 300kPa, and the moving speed of the barrel is 8mm / s.

[0064] (3) Sintering: the stent was heated up to 1350°C at a rate of 2°C / min for sintering, the sintering atmosphere was air, and the holding time was 3h.

[0065] (4) Magnesium thermal reduction treatment: place the sintered bracket in a crucible boat, cover the surface of the bracket evenly with a layer of magnesium powder 1-3mm thick, and then place the crucible boat in an argon atmosphere furnace at 2°C / The temperature was raised to 550°C for 1 min, and the temperature was kept for 1 h. Naturally cooled to room temperature, the gray...

Embodiment 3

[0068] (1) Ingredients and mixing: take 5g of white Ca 2 MgSi 2 o 7 The ceramic powder, 0.3g of sodium alginate powder and 3.2g of 20wt% F-127 solution were mixed evenly (the mixing method was manual stirring), and the 3D printing slurry was obtained.

[0069] (2) Printing: use the obtained 3D printing slurry to print the bracket with a 3D printer, the printing parameters are printing pressure of 300kPa, and the moving speed of the barrel is 8mm / s.

[0070] (3) Sintering: the stent was heated up to 1350°C at a rate of 2°C / min for sintering, the sintering atmosphere was air, and the holding time was 3h.

[0071] (4) Magnesium thermal reduction treatment: place the sintered bracket in a crucible boat, cover the surface of the bracket evenly with a layer of magnesium powder 1-3mm thick, and then place the crucible boat in an argon atmosphere furnace at 2°C / The temperature was raised to 600°C for 1 min, and the temperature was kept for 1 h. Cool naturally to room temperature ...

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Abstract

The invention relates to a bioactive ceramic scaffold for bone tissue repair and tumor treatment and a preparation method thereof. The bioactive ceramic scaffold is prepared from a white bioactive ceramic scaffold through magnesiothermic reduction treatment. The white bioactive ceramic scaffold is prepared from the following components: at least one of crystalline akermanite Ca2MgSi2O7, crystalline beta-tricalcium phosphate Ca3(PO4)2 and crystalline hydroxyapatite Ca5(PO4)3(OH).

Description

technical field [0001] The invention relates to a bioactive ceramic support for preparing bone tissue repair materials and treating tumor materials and a preparation method thereof, belonging to the field of biomaterials. Background technique [0002] 3D printed bioceramic scaffolds can promote the regeneration of bone tissue very well. The inherent large pores of the scaffolds can provide sufficient space for cell activity, transfer and interaction[1] and the silicon ions released by the bioceramic scaffolds themselves also have Certain angiogenic effects. The function of the bioceramic stent without any treatment is relatively simple, so the surface of the stent is often modified to make the stent have the function of tumor treatment. Our research group grows sulfide, selenide, etc. on the surface of the ceramic stent to endow the stent with excellent photothermal performance. However, the operation process of the surface modification of the scaffold is too complicated, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/22C04B35/622A61L27/10A61L27/12A61L27/50A61L27/54
CPCC04B35/22C04B35/622A61L27/10A61L27/12A61L27/54A61L27/50C04B2235/3206C04B2235/6562C04B2235/6567C04B2235/9661A61L2430/02A61L2300/412A61L2300/416A61L2300/102A61L2300/112
Inventor 吴成铁王鑫
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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