Terbium dysprosium iron flexible magnetoelastic film biosensor and preparation method thereof

Abstract

The invention belongs to the technical field of biosensors, particularly relates to a terbium dysprosium iron flexible magnetoelastic film biosensor and a preparation method thereof, and solves the problems that a traditional magnetoelastic sensor is poor in flexibility and low in sensitivity, and the defects that an existing magnetoelastic sensor is complex in response detection method and poor in anti-jamming capability and accuracy. The biosensor is prepared from the following raw materials: terbium dysprosium iron powder, liquid paraffin and a linear triblock copolymer, a terbium dysprosium iron flexible film is prepared by uniformly compounding and doping the terbium dysprosium iron powder through the linear triblock copolymer, and then a surface-aminated terbium dysprosium iron flexible film and an antibody-modified terbium dysprosium iron film are prepared in sequence. Then, closing treatment is performed on a non-specific site of the terbium dysprosium iron film modified by the antibody. According to the invention, the large-size giant magnetostrictive material terbium dysprosium iron is applied to the miniaturized portable biosensor, and the to-be-detected object is detected by measuring the magnetic conductivity or the impedance variation, so that the accuracy of signal testing and the stability of the system are improved.

Description

technical field [0001] The invention relates to the technical field of biosensors, in particular to a terbium-dysprosium-iron flexible magnetoelastic film biosensor and a preparation method thereof. Background technique [0002] So far, the preparation of magnetoelastic biosensors is based on rigid metal alloy materials such as iron-nickel alloys and nickel-cobalt alloys. Poor flexibility, high cost, complex preparation process and other problems. Magnetoelastic sensors at this stage usually use a vector network analyzer to measure the resonant frequency change of the magnetostrictive material before and after the object to be tested for quantitative detection. The detection method is single, the equipment is expensive, time-consuming, and the test steps are complex and resistant. The interference ability is poor, and the external micro vibration has a great influence on the measurement accuracy and system stability. Therefore, it is urgent to explore new flexible substrat...

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Problems solved by technology

However, at present, terbium-dysprosium-iron alloys are usually used in the form of blocks or columns to manufacture large-scale instruments such as linear motors, servo valves, powerful hydraulic pumps, high-speed valves, fuel injection systems (automotive engines), etc. Due to the large particle size of terbium-dysprosium-iron powder, It is not easy to achieve uniform doping to prepare composite films, which cannot be applied to miniature and portable biosensors

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