Multi-kinase inhibitors of VEGF and tgf[beta] and uses thereof

A mammalian, angiogenesis technology, applied in medical formulations containing active ingredients, anti-inflammatory agents, non-central analgesics, etc., can solve problems such as unsatisfactory treatment strategies, complex pathophysiology, and incomplete understanding.
CN112839652APending Publication Date: 2021-05-25AIVIVA BIOPHARMA INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
AIVIVA BIOPHARMA INC
Publication Date
2021-05-25

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Abstract

A pharmaceutical composition for prevention or treatment of a disease or disorder characterized by chronic inflammation, associated with angiogenesis and fibrosis. The pharmaceutical composition includes a multi-target inhibitor, multi-phase modulator, or multi-kinase inhibitor, such as axitinib, nintedanib, pirfenidone, riociguat, sorafenib, sunitinib, lenvatinib, regorafenib, ponatinib, or pazopanib.
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Description

technical field

[0001] The present disclosure relates to methods of preventing and treating diseases or conditions characterized by chronic inflammation associated with angiogenesis and fibrosis, such as psoriasis, rosacea, erythema multiforme, bullous Pemphigus, Hereditary Hemorrhagic Telangiectasia, Rheumatoid Arthritis, Atopic Dermatitis, and Skin Wound Healing. Background technique

[0002] Chronic inflammation associated with angiogenesis and fibrosis is a feature of many diseases such as psoriasis, rheumatoid arthritis and rosacea. While these broad pathologies are contributing factors, the underlying causes of these disorders are often unclear.

[0003] For example, the cause of rosacea, which is characterized by facial redness, dilated blood vessels, papules, pustules, and swelling on the skin of the face, remains unknown. It is well known that episodic symptoms of flushing and redness may play a role in the development of rosacea, whatever the trigger.

[0004] S...

Claims

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