Preparation method of DL-hydroxy selenomethionine

Abstract

The invention belongs to the field of preparation of organic compounds. The invention provides a preparation method of DL-hydroxy selenomethionine. The method is characterized in that gamma-butyrolactone is used as a raw material, alpha-hydroxyl-gamma-butyrolactone is synthesized through alpha-bromination and hydroxylation, and then the alpha-hydroxyl-gamma-butyrolactone reacts with sodium methyl selenol to obtain the DL-hydroxyl selenomethionine. The method has the advantages of easily available raw materials, mild reaction conditions and low cost, and is suitable for large-scale preparation of DL-hydroxyselenomethionine.

Description

technical field [0001] The invention belongs to the field of preparation of organic compounds. The invention relates to a method for preparing DL-hydroxyselenomethionine. Background technique [0002] Selenium is an indispensable trace element in humans and animals, and has significant effects in preventing and inhibiting cancer and delaying aging. Human cancer, cardiovascular and cerebrovascular diseases, children's mental retardation, senile dementia and other 42 diseases are related to selenium deficiency. Selenium deficiency in animals can lead to increased mortality, muscle atrophy and other symptoms. Therefore, the World Health Organization defined selenium as an essential trace element for humans and animals in 1973. Inorganic selenium is the first-generation selenium source. Sodium selenite and sodium selenate can be used as feed additives. Although the price is low, they are mainly absorbed through simple diffusion, poor absorption by organisms, and low effective...

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Problems solved by technology

The original research process route of DL-hydroxyselenomethionine is to use methyl lithium and selenium to prepare lithium methyl selenide in ether, and then react with α-hydroxybutyrolactone to prepare it. This process not only uses flammable and explosive Methyl lithium and ether, but also use the difficult-to-obtain α-hydroxybutyrolactone as a raw material, the industrial production cost is high (WO2006008190A2); another process route is to use methylselenol and acrolein to react to prepare 3-methylselenopropane Aldehydes, and then hydrolyzed after adding highly toxic reagents sodium cyanide or hydrogen cyanide, this route not only uses cyanide, hydrogen selenide, acrolein and other toxic reagents, but also selenium intermediates with poor stability The reaction route is long, the quality in the process is not easy to control, and the requirements for industrial production conditions are very harsh (CN109232342A)

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