Method for preparing L-selenomethionine

Abstract

The invention discloses a method for preparing L-selenomethionine and belongs to the field of additives. The method comprises the following steps: A. subjecting L-methionine and iodomethane to a reaction in water, so as to obtain an intermediate; and B. subjecting the intermediate and selenium sodium methoxide to a reaction in an alcoholic solvent, carrying out quenching with glacial acetic acid after the reaction ends up, adjusting a pH value of a reaction system to 5 to 6, and carrying out filtering and baking, thereby obtaining the L-selenomethionine. The method has the beneficial technicaleffects that the intermediate is simpler in preparation and lower in cost; the preparation operation of the intermediate is simpler; and employed raw materials and reagents are commercially available, a reaction process is free of production of fetid and hypertoxic byproduct, and thus, the method is more beneficial to labor protection and environments.

Description

technical field

[0001] The invention belongs to the field of additives, and in particular relates to a preparation method of L-selenomethionine. Background technique

[0002] L-selenomethionine is an organic selenium compound in which selenium exists in plants and feed grains in an organic form in nature. Compared with inorganic selenium, selenomethionine has the advantages of less toxicity, less environmental pollution, and high bioavailability[Environment Research, 2005, 98(1): 46-54]. At present, many European and American countries have vigorously advocated the use of organic selenium. For example, Sweden requires the use of organic selenium in suckling pig feed; Japan has stipulated that the use of inorganic selenium in feed is prohibited. Selenomethionine is stable in nature and has remarkable efficacy [Current Protein and Peptide Science, 2014, 15(6): 598-607]. It has high practical value and broad prospects for promotion and application.

[0003] At present, the pr...

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