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Multi-scale biological scaffold and manufacturing method and application thereof

A technology of biological scaffolds and manufacturing methods, applied in tissue regeneration, medical science, prostheses, etc., to achieve the effect of guiding cell growth, promoting migration and penetration, and promoting healing

Active Publication Date: 2021-06-08
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Most of the current tissue engineering scaffold designs cannot meet the above requirements at the same time

Method used

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  • Multi-scale biological scaffold and manufacturing method and application thereof
  • Multi-scale biological scaffold and manufacturing method and application thereof
  • Multi-scale biological scaffold and manufacturing method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Embodiment 1: volume layer structure

[0069] Use CAD technology to design the pattern of the plane structure, and then export the Gcode file that can be recognized by 3D printing.

[0070] Input the generated Gcode file into such as figure 1 The shown near-field direct writing 3D printing system (mainly including printing nozzles, barrels, barrel heaters, nozzle heating heads, substrates, etc.), by adjusting the nozzle-substrate distance, extrusion pressure, printing speed, and voltage value, For parameters such as heater temperature, a planar support structure is deposited on the bearing surface of the substrate (in this embodiment, the substrate is a glass plate). In the preset structure, the diameter of the thick fiber (that is, the circumferential fiber) is 50-60 microns, and the diameter of the thin fiber (that is, the axial fiber) is 10 microns, so the printing parameters are set as follows: the distance between the nozzle and the substrate is 2.5mm, and the noz...

Embodiment 2

[0084] Embodiment 2: Cylindrical structure

[0085] Such as Figure 4 As shown in b, the rotary 3D printer is used to input the pre-set path file, and the cylindrical biological scaffold is directly printed at one time through the joint action of the xz axis and the rotation of the rotating shaft.

[0086] In the above-mentioned path file, the printing path of the thin fiber (axial fiber) in the main axis direction is mainly realized by the translation of the x-axis, while the printing path of the thick fiber in the circumferential direction is mainly realized by the rotation of the rotating shaft.

[0087] The parameters for setting the rotary 3D printing are: the distance between the nozzle and the rotating shaft is 2.5mm, the diameter of the nozzle is 150 microns, the air pressure is 100kPa, the voltage is 4.7kv, the heating degree of the barrel is 105°C, and the heating temperature of the nozzle is 105°C.

[0088] When printing axial fibers, the translation speed of the x...

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Abstract

The invention provides a multi-scale biological scaffold and a manufacturing method and application thereof. The biological scaffold comprises a plurality of axial fibers and a plurality of circumferential fibers, wherein the plurality of axial fibers and the plurality of circumferential fibers are arranged in a staggered mode, the diameter of the axial fibers is 2-20 microns, the diameter of the circumferential fibers is 50 microns to 2mm, and the arrangement spacing between the adjacent circumferential fibers is larger than that between the adjacent axial fibers. According to the manufacturing method, 3D printing, electrostatic spinning and casting molding are adopted, or any one of the methods is combined with a film rolling process. The application is the application of the multi-scale biological scaffold in manufacturing of a tissue engineering scaffold. The biological scaffold gives consideration to the specific surface area and the pore size, in-vivo oriented tissue is well simulated, cells are loaded on the scaffold, the oriented growth state can be shown, functionalization is well achieved, and the biological scaffold can be further applied to tissue engineering repair.

Description

technical field [0001] The invention belongs to the technical field of biological manufacturing and design, and in particular relates to a multi-scale biological scaffold and its manufacturing method and application. Background technique [0002] In recent years, the concept of tissue engineering for tissue repair has attracted more and more attention, and its effectiveness has been verified by more and more studies. The tissue engineering method is to mix or pre-culture scaffolds, cells, and related cytokine nutrients outside the carrier, and transplant them into the body after achieving a certain tissue function for rapid repair. Therefore, the design of tissue engineering scaffolds is crucial to the final repair effect and the functional realization of pre-cultured tissues. [0003] In human tissue, there are many directional fiber tissues, such as nerve fibers in the nervous system, muscle fibers in muscle tissue, and directional myocardial fibers in myocardial tissue, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/20A61L27/22A61L27/58A61L27/56A61L27/38B33Y10/00B33Y70/00B33Y80/00
CPCA61L27/18A61L27/20A61L27/222A61L27/383A61L27/3834A61L27/3878A61L27/56A61L27/58A61L2430/32B33Y10/00B33Y70/00B33Y80/00
Inventor 贺永吕尚陈伟傅建中
Owner ZHEJIANG UNIV
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