Application of Akkermansia muciniphila in the aspect of treating chronic pancreatitis

A technology for chronic pancreatitis and pancreatic atrophy, applied in the direction of application, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve unclear problems, reduce release, broaden application fields, and relieve inflammation The effect of infiltration
CN112933115AActive Publication Date: 2021-06-11JIANGNAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
JIANGNAN UNIV
Publication Date
2021-06-11

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Abstract

The invention discloses application of Akkermansia muciniphila in the aspect of treating chronic pancreatitis, and belongs to the application field of probiotics. The invention provides the application of an Akkermansia muciniphila BAA-835 strain in preparation of a product for treating chronic pancreatitis, and the strain can relieve pancreatic atrophy symptoms, acinus cell injury and inflammation infiltration, reduce release of proinflammatory cytokines and infiltration of macrophages, relieve pancreatic fibrosis degree in an active state or an inactive state, improve pancreatic fibrosis resistance and improve pancreatic fibrosis resistance. The compound can be used for preparing medicines, pharmaceutical compositions, functional foods and feeds for treating chronic pancreatitis, and has a wide application prospect.
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Description

technical field

[0001] The invention discloses the application of Akkermansia muciniphila in treating chronic pancreatitis, in particular relates to the application of Akkermansia muciniphila BAA-835 strain in treating chronic pancreatitis, and belongs to the application field of probiotics. Background technique

[0002] Chronic pancreatitis is a multifactorial inflammatory pancreatic disease that can cause irreversible damage to pancreatic tissue and function. The main pathogenic factors of chronic pancreatitis are alcoholism, smoking, high-fat and high-protein diet, genetic factors and so on. At present, chronic pancreatitis affects 1 / 2000 of the world's population, and 13% of chronic pancreatitis patients will progress to pancreatic cancer, which has a serious impact on the lives of patients. The clinical manifestations of chronic pancreatitis are various, and the pathogenesis is not fully clear, so there is no effective drug for the treatment of chronic pancreatitis. T...

Claims

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