Unlock instant, AI-driven research and patent intelligence for your innovation.

Transparent hydrogel based on chitosan and preparation method thereof

A chitosan and hydrogel technology, applied in the field of chitosan-based transparent hydrogel and its preparation, can solve the problems of reducing the biocompatibility of the system, complicated synthesis process, etc., and achieve good mechanical properties and high transparency Effect

Pending Publication Date: 2021-06-11
UNIV OF SCI & TECH OF CHINA
View PDF8 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, a large number of reactants are introduced in the process of chemical cross-linking and then ion treatment, which reduces the biocompatibility of the system and the synthesis process is cumbersome.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Transparent hydrogel based on chitosan and preparation method thereof
  • Transparent hydrogel based on chitosan and preparation method thereof
  • Transparent hydrogel based on chitosan and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0036] The present invention also provides a kind of preparation method of above-mentioned transparent hydrogel based on chitosan, comprising: S) mixing chitosan and aldehyde small molecule cross-linking agent in water, heating reaction, obtains chitosan-based Transparent hydrogel.

[0037] Wherein, the present invention does not have special restriction to the source of all raw materials, just can be commercially available; The kind and the ratio of described chitosan and aldehyde small molecule cross-linking agent are all the same as above-mentioned, do not repeat them here; In the present invention, unless otherwise specified, the amount of chitosan is calculated according to its single chain link.

[0038] Chitosan and aldehyde small molecule cross-linking agent are mixed in water; in the present invention, chitosan is preferably dispersed in water first, and then the aqueous solution of aldehyde small molecule cross-linking agent is added under heating conditions, and sti...

Embodiment 1

[0045] (1) Take 0.12 g of glyoxylic acid monohydrate and dissolve it in 3 mL of deionized water at room temperature to obtain solution A.

[0046] (2) Disperse 0.2 g of high-viscosity chitosan (>400 mPa s) in 3 mL of deionized water, add the entire volume of solution A under heating at 50 ° C and magnetic stirring, and continue heating and stirring for 20 min to obtain a clear yellowish viscous Solution B.

[0047] (3) Take solution B and sonicate it for one minute to remove small air bubbles, draw it into a 1mL syringe, cover the syringe cap, and place it in an oven at 70°C.

[0048] (4) After 4 hours, the syringe was taken out, the gel was pushed out, soaked in excess deionized water, and a chitosan-based transparent hydrogel (CSG hydrogel) was obtained after swelling.

[0049] Wherein, in this reaction system, the mass concentration of chitosan is 3.16%, the mass concentration of glyoxylic acid is 1.90%, and the mass ratio of chitosan and glyoxylic acid is 1:1.05 (chitosan...

Embodiment 2

[0051] (1) Take 0.09 g of glyoxylic acid monohydrate and dissolve it in 3 mL of deionized water at room temperature to obtain solution A.

[0052] (2) Disperse 0.2 g of high-viscosity chitosan (>400 mPa s) in 3 mL of deionized water, add the entire volume of solution A under heating at 50 ° C and magnetic stirring, and continue heating and stirring for 20 min to obtain a clear yellowish viscous Solution B.

[0053] (3) Take solution B and sonicate it for one minute to remove small air bubbles, draw it into a 1mL syringe, cover the syringe cap, and place it in an oven at 70°C.

[0054] (4) After 4 hours, take out the syringe, push out the gel, soak in excess deionized water, and obtain CSG hydrogel after swelling.

[0055] Wherein, in this reaction system, the feeding mass concentration of chitosan is 3.17%, the feeding mass concentration of glyoxylic acid is 1.43%, and the amount ratio of the feeding material of chitosan and glyoxylic acid is 1:0.78 (chitosan Sugar is calcul...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
viscosityaaaaaaaaaa
concentrationaaaaaaaaaa
tensile strengthaaaaaaaaaa
Login to View More

Abstract

The invention provides a transparent hydrogel based on chitosan and a preparation method thereof, wherein the transparent hydrogel has ultrahigh water content, high transparency and better mechanical property. The chitosan hydrogel only contains chitosan as a sole polymer, the chitosan hydrogel is crosslinked by using small-molecule glyoxylic acid, the synthesis method is simple and easy to implement, and the water content and mechanical strength of the final hydrogel can be adjusted by adjusting the initial feeding ratio and feeding concentration. Besides, the chitosan hydrogel overcomes the defect that existing hydrogel is difficult to have high water content, high transparency and high biocompatibility at the same time, the water content can reach 99.7%-99.9%, the transparency in the visible light range is close to 100%, meanwhile, the strength of the chitosan hydrogel is close to that of animal tendons, and the chitosan hydrogel can be applied to the field of biological medicine.

Description

technical field [0001] The invention belongs to the field of hydrogel technology, in particular to a chitosan-based transparent hydrogel and a preparation method thereof. Background technique [0002] With the development of biomaterials and biotechnology, research on biopolymer-based hydrogels has emerged. Biopolymer hydrogels combine the advantages of biopolymers and hydrogels: biopolymers have better biocompatibility, while hydrogels have superior mechanical properties and flexible processability. Many macromolecules that exist in nature (called natural macromolecules) have been used in cell culture, tissue engineering, implantable devices and other fields. Hydrogel materials based on biopolymers have gradually entered the field of vision of researchers. The development of new biopolymer hydrogels that are closer to biological tissues and more environmentally friendly, and their application to the field of biomedicine is one of the key directions in the future of the bi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08J3/24C08L5/08C08K5/09
CPCC08J3/075C08J3/24C08J2305/08C08K5/09
Inventor 马明明李元亨
Owner UNIV OF SCI & TECH OF CHINA