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Method for identifying production source of D-glucosamine derivative and application thereof

A technology of glucosamine and glucosamine hydrochloride, applied in the field of detection, to achieve the effect of light stain color, simple method and convenient cleaning

Pending Publication Date: 2021-06-11
JIANGSU AOXIN BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The D-glucosamine hydrochloride, D-glucosamine sulfate potassium salt and D-glucosamine sulfate sodium salt obtained by chemical synthesis and biological fermentation are all high-purity products, and their purity is higher than 99%. The D-glucosamine hydrochloride, D-glucosamine sulfate potassium salt and D-glucosamine sulfate sodium salt have very similar physical and chemical properties, however, there is no relevant method at present from D-glucosamine hydrochloride, D-glucosamine sulfate potassium salt and D-glucosamine sulfate sodium salt powder or products containing D-glucosamine sulfate potassium salt and D-glucosamine sulfate sodium salt are identified as biological fermentation methods Process source or chemical synthesis process source

Method used

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  • Method for identifying production source of D-glucosamine derivative and application thereof
  • Method for identifying production source of D-glucosamine derivative and application thereof
  • Method for identifying production source of D-glucosamine derivative and application thereof

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Embodiment 1

[0046] Embodiment 1 of the present invention provides a method for identifying the production source of D-glucosamine derivatives, which is to use combustion-isotope mass spectrometry to determine the carbon isotope abundance value δ 13 C. Nitrogen isotope abundance value δ 15 N, oxygen isotope abundance value δ 18 O, according to the obtained δ 13 C, delta 15 N, δ 18 O identify its source of production, as follows:

[0047] After the test sample D-glucosamine derivative was treated in an oven at 70°C for 24 hours, it was wrapped and sealed with tin foil and placed in the combustion furnace of the elemental analyzer for combustion at 1300°C. The CO formed by the combustion product 2 、H 2 O, N 2 The mixed gas with nitrogen oxides passes through the silver-plated cobalt trioxide and the 820°C reduction tube containing copper element in turn, and the CO is separated by a purge and trap adsorption column. 2 and N 2 , using isotope mass spectrometry to measure the marked 1...

Embodiment 2

[0050] Embodiment 2 of the present invention provides a method for identifying the production source of D-glucosamine derivatives, which is to use combustion-isotope mass spectrometry to determine the carbon isotope abundance value δ 13 C. Nitrogen isotope abundance value δ 15 N, according to the obtained δ 13 C, delta 15 N identifies its source of production as follows:

[0051] After the test sample D-glucosamine derivative was treated in an oven at 70°C for 24 hours, it was wrapped and sealed with tin foil and placed in the combustion furnace of the elemental analyzer for combustion at 1350°C. The CO formed by the combustion product 2 、H 2 O, N 2 The mixed gas with nitrogen oxides passes through the silver-plated cobalt trioxide and the 840°C reduction tube containing copper element in turn, and the CO is separated by a purge and trap adsorption column. 2 and N 2 , using isotope mass spectrometry to measure the marked 13 The carbon isotope abundance value of the glut...

Embodiment 3

[0054] Embodiment 3 of the present invention provides a method for identifying the production source of D-glucosamine derivatives, which is to use combustion-isotope mass spectrometry to determine the carbon isotope abundance value δ 13 C. Nitrogen isotope abundance value δ 15 N, according to the obtained δ 13 C, delta 15 N identifies its source of production as follows:

[0055] After the test sample D-glucosamine derivative was treated in an oven at 70°C for 24 hours, it was wrapped and sealed with tin foil and placed in the combustion furnace of the elemental analyzer for combustion at 1320°C. The CO formed by the combustion product 2 、H 2 O, N 2 The mixed gas with nitrogen oxides passes through the silver-plated cobalt trioxide and the 830°C reduction tube containing copper element in turn, and the CO is separated by a purge and trap adsorption column. 2 and N 2 , using isotope mass spectrometry to measure the marked 13 The carbon isotope abundance value of the glut...

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Abstract

The invention relates to the technical field of detection, in particular to a method for identifying a production source of a D-glucosamine derivative and application of the method. According to the application, a combustion-isotope mass spectrometry technology is used for determining a carbon isotope abundance value delta<13>C, a nitrogen isotope abundance value delta<15>N or an oxygen isotope abundance value delta<18>O to identify the production source of the D-glucosamine derivative; wherein the D-glucosamine derivative comprises one or more of D-glucosamine hydrochloride, D-glucosamine potassium sulfate salt and D-glucosamine sodium sulfate salt. The method for identifying the production source of the D-glucosamine derivative is simple and accurate, and when the D-glucosamine derivative is a mixture, the identification method is also not affected.

Description

technical field [0001] The invention relates to the technical field of detection, more specifically, the invention relates to a method for identifying the production source of D-glucosamine derivatives and its application. Background technique [0002] The original process of D-glucosamine hydrochloride is extracted from natural chitin. It is a marine biological preparation that can promote the synthesis of mucopolysaccharides in the human body, improve the viscosity of joint synovial fluid, and improve the metabolism of articular cartilage; The role of injection efficacy, used to synthesize water-soluble anticancer drug chlorureamycin, which has the anticancer properties of nitrosourea compounds, and at the same time has the characteristics of less bone marrow inhibition, and is effective for melanoma, lung cancer, kidney cancer And so on to show a certain effect. D-Glucosamine Sulfate Sodium Salt can treat clinical functions such as stomatitis, suppurative eczema, arthrit...

Claims

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Application Information

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IPC IPC(8): G01N27/62
CPCG01N27/62
Inventor 张福明王松叶詹小远詹金明王飞
Owner JIANGSU AOXIN BIOTECHNOLOGY CO LTD