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Probenecid solution and preparation method thereof

A technology of probenecid and solution, which is applied in the direction of medical formulas, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., which can solve the problems of farmers' economic losses, application restrictions, and lower serum urate levels. Achieve the effects of avoiding catalytic oxidation, maintaining long-term stability, and maintaining safety and effectiveness

Pending Publication Date: 2021-06-15
HEBEI KEXING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Avian gout is a common metabolic disease, which is mainly caused by the deposition of uric acid in the blood in the joints. Avian gout can cause weight loss, weakness, slow movement, joint swelling and diarrhea in poultry, affect egg production rate, and even cause poultry to lose weight. death, causing serious economic losses to the farm
[0003] At present, the treatment of poultry gout mainly adopts the methods of mixing diuretic and swelling Chinese herbal medicine in the feed, stopping the use of sulfonamides, and reducing the calcium content in the feed. serious economic loss
[0004] Probenecid, also known as carboxybenzenesulfonamide, is a white crystalline powder that can be used to inhibit the reabsorption of urate in the renal tubules, increase the urinary excretion of uric acid, and reduce the serum urate level, so as to achieve the effect of rapid treatment of gout; but Probenecid is insoluble in water and cannot be made into liquid preparations, which greatly limits its application

Method used

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  • Probenecid solution and preparation method thereof
  • Probenecid solution and preparation method thereof
  • Probenecid solution and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Embodiment 1 A kind of preparation method of probenecid solution

[0032] This embodiment is carried out according to the following sequence of steps:

[0033] S1. Get 500L of purified water, add 0.55kg of sodium sulfite as an antioxidant, 0.15kg of disodium edetate as a complexing agent, 0.25kg of sodium ethylparaben as a preservative and 3.50kg of sodium hydroxide as a cosolvent, Fully dissolve and stir evenly to obtain solution A1;

[0034] S2. Add 20kg of probenecid to solution A1, fully stir and dissolve to obtain solution B1;

[0035] S3. add 5kgPVP-K30 in solution B1, dissolve, stir well; Then add 52kg propylene glycol as the first kind of stabilizer, stir well; Then add 5kg Tween-80 as the second kind of stabilizer; Use purified water to settle to 990L, mix well, dilute 1mL solution 20 times, measure pH value, add sodium hydroxide to adjust pH, mix well,

[0036] Take 1mL of the solution and dilute it 20 times, measure the pH value, adjust the pH repeatedly u...

Embodiment 2～10

[0038] The preparation method of embodiment 2~10 probenecid solution

[0039] Embodiments 2 to 10 are respectively a preparation method of probenecid solution, and their preparation steps are basically the same as in Example 1, the difference is only in the amount of raw materials and the difference in process parameters, see the following table for details:

[0040] List of raw material consumption and process parameters in Table 1 Examples 2 to 10

[0041]

[0042]

[0043]

Embodiment 1

[0044] Comparative example 1 ' a kind of preparation method of probenecid solution

[0045] This comparative example is a preparation method of probenecid solution, and its preparation steps are basically the same as in Example 1, the only difference is that the stabilizer used in this comparative example is the first type of stabilizer, and the obtained probenecid Shu solution is labeled F1'.

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Abstract

The invention discloses a probenecid solution and a preparation method thereof. The probenecid solution is prepared from probenecid, a cosolvent, an antioxidant, a complexing agent, a preservative and a stabilizer as raw materials by mixing, pH adjustment, volume metering and filtration. According to the preparation method, the dosage of the selected auxiliary materials is controlled within a safe range, the safety is good, the preparation process is simple, the operation is easy, the production cost is relatively low, and the prepared probenecid solution product is safe in quality, controllable and good in stability, can be used for treating poultry gout, and has the characteristics of being accurate n dosage, easy to administer and convenient to use when being used.

Description

technical field [0001] The invention belongs to the technical field of animal husbandry and veterinary medicine, and relates to a medicine for poultry, in particular to a probenecid solution and a preparation method thereof. Background technique [0002] Avian gout is a common metabolic disease, which is mainly caused by the deposition of uric acid in the blood in the joints. Avian gout can cause weight loss, weakness, slow movement, joint swelling and diarrhea in poultry, affect egg production rate, and even cause poultry to lose weight. death, causing serious economic losses to the farm. [0003] At present, the treatment of poultry gout mainly adopts the methods of mixing diuretic and swelling Chinese herbal medicine in the feed, stopping the use of sulfonamides, and reducing the calcium content in the feed. serious economic loss. [0004] Probenecid, also known as carboxybenzenesulfonamide, is a white crystalline powder that can be used to inhibit the reabsorption of u...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/195A61K47/10A61K47/12A61K47/14A61K47/18A61K47/20A61K47/26A61K47/44A61P19/06
CPCA61K31/195A61K9/08A61K47/10A61K47/18A61K47/20A61K47/26A61K47/44A61P19/06A61K47/183A61K47/12A61K47/14
Inventor 李凤英陈淑芳郭艳玉
Owner HEBEI KEXING PHARMA
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