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Progesterone capsule and preparation method thereof

A progesterone and capsule technology, which is applied in the directions of capsule delivery, pharmaceutical formulations, and non-active ingredients medical preparations, can solve the problems of harsh preparation process conditions, increase the economic burden of patients, and add complex components, and reduce the economic burden, The effect of reducing production cost and easy preparation

Pending Publication Date: 2021-06-22
河北今水生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, traditionally, when progesterone drugs are made into capsules, the added ingredients are too complicated, and the preparation process conditions are relatively harsh, resulting in high costs and increasing the economic burden of patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

no. 1 example

[0064] A preparation method for progesterone capsules, comprising the steps of:

[0065] (1) Preparation of progesterone powder:

[0066] (a): primary mix:

[0067] S1: Firstly, sterilize various raw materials. You can choose 200,000 rad (50.16C / kg) irradiation dose for irradiation sterilization.

[0068] S2: Inject 25% of acetone solvent into the sterilized reaction kettle and heat it to 50°C. During the heating process, slowly stir the acetone solvent to make it evenly heated, and add 45% of the carrier to the acetone solvent Glyceryl monostearate;

[0069] S3: Add 15% progesterone, an active drug ingredient, into the acetone solvent in the reaction kettle, and continue stirring;

[0070] S4: Put 2% sodium octadecyl sulfate into the reaction kettle, continue stirring to dissolve it;

[0071] S5: taking out the mixed solution in the reactor for use;

[0072] (b): dry crushing treatment

[0073] Q1: Dry the reserved mixed solution from (a) S5 through a vacuum dryer;

[...

no. 2 example

[0088] A preparation method for progesterone capsules, comprising the steps of:

[0089] (1) Preparation of progesterone powder:

[0090] (a): primary mix:

[0091] S1: Firstly, sterilize various raw materials. You can choose 200,000 rad (50.16C / kg) irradiation dose for irradiation sterilization.

[0092] S2: Inject 15% acetone solvent into the sterilized reaction kettle and heat it to 50°C. During the heating process, slowly stir the acetone solvent to make it evenly heated, and add 35% of the carrier to the acetone solvent Glyceryl monostearate;

[0093] S3: Add 35% of the active drug ingredient progesterone into the acetone solvent in the reaction kettle, and continue stirring;

[0094] S4: Put 4% sodium octadecyl sulfate into the reaction kettle, continue stirring to dissolve it;

[0095] S5: taking out the mixed solution in the reactor for use;

[0096] (b): dry crushing treatment

[0097] Q1: Dry the reserved mixed solution from (a) S5 through a vacuum dryer;

[0...

no. 3 example

[0112] A preparation method for progesterone capsules, comprising the steps of:

[0113] (1) Preparation of progesterone powder:

[0114] (a): primary mix:

[0115] S1: Firstly, sterilize various raw materials. You can choose 200,000 rad (50.16C / kg) irradiation dose for irradiation sterilization.

[0116] S2: Inject 20% of acetone solvent into the sterilized reaction kettle and heat it to 50°C. During the heating process, slowly stir the acetone solvent to make it evenly heated, and add 40% of the carrier to the acetone solvent Glyceryl monostearate;

[0117] S3: Add 25% of the active drug ingredient progesterone into the acetone solvent in the reaction kettle, and continue stirring;

[0118] S4: Put 3% sodium octadecyl sulfate into the reaction kettle, continue stirring to dissolve it;

[0119] S5: taking out the mixed solution in the reactor for use;

[0120] (b): dry crushing treatment

[0121] Q1: Dry the reserved mixed solution from (a) S5 through a vacuum dryer;

...

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Abstract

The invention provides a progesterone capsule and a preparation method thereof. The progesterone capsule comprises progesterone medicine powder and a capsule shell, and the progesterone medicine powder mainly comprises 15%-40% of progesterone serving as an effective medicine component, 10%-60% of glycerin monostearate serving as a carrier, 15%-25% of an acetone solvent, 1%-4% of sodium octadecyl sulfate, 0.5%-1% of superfine silica powder, 0.5%-1% of magnesium stearate, 3%-15% of starch and 2%-10% of cane sugar. The capsule shell mainly comprises the following components in percentage by weight: 15%-30% of gelatin and 70%-85% of starch. The progesterone capsule and the preparation method have the advantages that the composition components are simple and easy to obtain, the preparation process is simplified, the process conditions are reduced, the production cost is reduced, and the economic burden of a patient is reduced.

Description

technical field [0001] The invention relates to the technical field of medicine preparation, in particular to a progesterone capsule and a preparation method. Background technique [0002] Progesterone, also known as progesterone hormone and luteinizing hormone, is the main biologically active progesterone secreted by the ovary. Progesterone can protect the endometrium of women. During pregnancy, progesterone hormone can provide support and protection for the early growth and development of the fetus, and can play a certain calming effect on the uterus. In addition, the relationship between progesterone and estrogen is inseparable, and both are very important female hormones. The function of estrogen is mainly to promote the development and maturation of female secondary sexual characteristics, while the progesterone hormone further promotes the development and maturation of secondary sexual characteristics on the basis of the action of estrogen, and there is a synergistic ...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/57A61K47/36A61P15/00A61P5/34
CPCA61K9/4866A61K31/57A61P15/00A61P5/34
Inventor 杨志伟
Owner 河北今水生物科技有限公司
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