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A kind of gel and preparation method thereof

A gel and thickener technology, applied in prosthesis, surgery, tissue regeneration, etc., can solve the problems of difficult control of molecular structure, reduce gel swelling, and high toxicity, so as to reduce costs, reduce pain, and avoid secondary surgery Effect

Active Publication Date: 2022-05-27
JIANGSU DISSUETECH MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is a gel formed by mixing PEG-SG with an electrophilic component (Tri-Lysis and polyethyleneimine (PEI)). The electrophilic component is composed of Tri-Lysis and PEI. Tri-Lysis can reduce the swelling of the gel , PEI can increase the speed of gelation, but PEI itself is highly toxic, and its molecular structure is not easy to control. Although it has been approved as a medical device, it still needs to pay attention to the dosage and location when applying

Method used

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  • A kind of gel and preparation method thereof
  • A kind of gel and preparation method thereof
  • A kind of gel and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0044] Raw materials: 4-arm-PEG-SG (purchased from SINOPEG, molecular weight of 20000), ε-PL (purchased from Zhengzhou Bainafo, model E-PLA, polymerization degree 25-35), HPMC (purchased from Xi'an Tianzheng, molecular weight range of 10000-1500000, viscosity 30000).

[0045] Neutral phosphate buffer: consists of 0.85% wtNaCl, 0.05% wtNa 2 HPO 4 and 0.015% wtNaH 2 PO 4 Configured with injectable water, the 0.22 μm membrane is packed in a transparent vials, sealed and sterilized under high pressure and heat.

[0046] Fundus Closure Gel Kit:

[0047]Component 1: Consists of a brown sealed vials (integral irradiation sterilization) containing 40 mg 4-arm-PEG-SG, now in use. 0.5 mL of neutral phosphate buffer is injected into the brown bottle above upon use, dissolved with gentle shaking, and then the solution is aspirated with a syringe and set aside.

[0048] Component 2: Consists of brown sealed vials (integral irradiation sterilization) containing 1 mg of ε-PL and 7 mg HPMC mixed ...

Embodiment 2

[0052] The difference from Example 1 is that component 1 contains 30mg 4-arm-PEG-SG, component 2 contains 0.5mg ε-PL and 8mg HPMC.

Embodiment 3

[0054] The difference from Example 1 is that component 1 contains 60mg 4-arm-PEG-SG, component 2 contains 3.5mg ε-PL and 15mg HPMC.

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Abstract

The invention discloses a gel and a preparation method thereof, belonging to the field of tissue material engineering. The gel is prepared from active substances including the following three components: Among them, the first component is N-hydroxysuccinimide-glutarate-modified PEG, and the second component is polymer Lysine, the third component is a thickener; wherein, the active substance does not include amino-modified polyethylene glycol and amino-modified polyethylene oxide derivatives. The swelling performance of the gel of the present invention can maintain low swelling and low shrinkage in the range of up to 180 days, which is very important for ophthalmic use, because a high swelling rate of the vitreous substitute will cause glaucoma due to increased intraocular pressure , If the fundus gel has a high swelling rate, it will pull the retina and cause retinal detachment.

Description

Technical field [0001] The present invention belongs to the field of tissue materials engineering, specifically relates to a gel and preparation method and application thereof. Background [0002] As a tissue engineering material, hydrogel is widely used in medicine, involving many applications such as anti-adhesion materials, hemostatic materials, bone defect repair filling stents, tissue adhesives, sustained release drug carriers, antibacterial and anti-infection dressings, etc. Polyethylene glycol (PEG) occupies a place in commercial biomaterials due to its good biocompatibility, adjustable molecular weight, narrow molecular weight distribution, and good stability between batches of raw materials. PEG terminal with hydroxyl group, through chemical reaction, can be more convenient to modify the PEG end group, such as carboxyl, amino, mercapto, methyl and the like. On the other hand, with the concept of minimally invasive surgery deeply rooted in the hearts of the people, on the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/26A61L27/52A61L27/50A61L31/04A61L31/06A61L31/14
CPCA61L27/26A61L27/52A61L27/50A61L31/041A61L31/145A61L31/14A61L2430/16C08L71/02C08L1/02C08L77/04
Inventor 曹彬吴亮亮朱健
Owner JIANGSU DISSUETECH MEDICAL TECH CO LTD
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