A kind of gel and preparation method thereof

A gel and thickener technology, applied in prosthesis, surgery, tissue regeneration, etc., can solve the problems of difficult control of molecular structure, reduce gel swelling, and high toxicity, so as to reduce costs, reduce pain, and avoid secondary surgery Effect
CN112999419BActive Publication Date: 2022-05-27JIANGSU DISSUETECH MEDICAL TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIANGSU DISSUETECH MEDICAL TECH CO LTD
Publication Date
2022-05-27

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Abstract

The invention discloses a gel and a preparation method thereof, belonging to the field of tissue material engineering. The gel is prepared from active substances including the following three components: Among them, the first component is N-hydroxysuccinimide-glutarate-modified PEG, and the second component is polymer Lysine, the third component is a thickener; wherein, the active substance does not include amino-modified polyethylene glycol and amino-modified polyethylene oxide derivatives. The swelling performance of the gel of the present invention can maintain low swelling and low shrinkage in the range of up to 180 days, which is very important for ophthalmic use, because a high swelling rate of the vitreous substitute will cause glaucoma due to increased intraocular pressure , If the fundus gel has a high swelling rate, it will pull the retina and cause retinal detachment.
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Description

Technical field

[0001] The present invention belongs to the field of tissue materials engineering, specifically relates to a gel and preparation method and application thereof. Background

[0002] As a tissue engineering material, hydrogel is widely used in medicine, involving many applications such as anti-adhesion materials, hemostatic materials, bone defect repair filling stents, tissue adhesives, sustained release drug carriers, antibacterial and anti-infection dressings, etc. Polyethylene glycol (PEG) occupies a place in commercial biomaterials due to its good biocompatibility, adjustable molecular weight, narrow molecular weight distribution, and good stability between batches of raw materials. PEG terminal with hydroxyl group, through chemical reaction, can be more convenient to modify the PEG end group, such as carboxyl, amino, mercapto, methyl and the like. On the other hand, with the concept of minimally invasive surgery deeply rooted in the hearts of the people, on the...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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