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Temperature-sensitive chitosan hydrogel composition and bioink composition comprising same

A gel composition, chitosan technology, applied in the direction of microorganisms, tissue regeneration, biochemical equipment and methods, etc., can solve the problems of low heat resistance, weak mechanical and physical properties, difficult to control the decomposition rate, etc.

Pending Publication Date: 2021-06-25
MEDIFAB CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the polymer is prone to thermal denaturation due to its low heat resistance, and rapidly decomposes in the body due to weak mechanophysical properties, so it has the disadvantage that it is difficult to control the decomposition rate.

Method used

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  • Temperature-sensitive chitosan hydrogel composition and bioink composition comprising same
  • Temperature-sensitive chitosan hydrogel composition and bioink composition comprising same
  • Temperature-sensitive chitosan hydrogel composition and bioink composition comprising same

Examples

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specific Embodiment approach

[0037] Hereinafter, the best examples are provided to facilitate understanding of the present disclosure. However, the following examples are provided only to help understand the present disclosure more easily, and the content of the present disclosure is not limited to the following examples.

Embodiment 1

[0040] 0.675 g of gelatin was added to 15 ml of 0.1 N HCl, and stirred at 500 rpm at 60° C. for 1 hour to prepare a gelatin solution. Afterwards, 0.6 g of chitosan was added to the gelatin solution, and then 0.3 ml of 0.5 M disodium phosphate (disodium phosphate, Na 2 HPO 4 ) and 0.5M glycerol to adjust the pH to 7. Thereafter, the solution was stored at 57° C. for 1 day, and it was confirmed that it had become a gel ( Figure 2a ).

Embodiment 2

[0042] 0.25 g of gelatin was added to 10 ml of 0.1 N HCl, and stirred at 500 rpm at 60° C. for 1 hour to prepare a gelatin solution. After that, 0.3 g of chitosan was added to the gelatin solution, and then a mixed solution of 0.5 M disodium hydrogen phosphate and 0.5 M glycerin was slowly added dropwise, thereby adjusting the pH to 6.8. Thereafter, the solution was preserved at 57° C. for 10 minutes, and it was confirmed that it became a gel ( Figure 2b ).

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Abstract

The present invention relates to a chitosan hydrogel composition comprising chitosan, glycerol, and a phosphate group, wherein the chitosan is crosslinked by glycerol, a phosphate group, or a combination thereof. The chitosan hydrogel composition enables temperature control for inducing a liquid-state composition into a gel state according to the content ratio of a phosphate group and glycerol, and since the concentration of gelatin affects the printing characteristics, strength, and the like, can be used as ink for 3D printers.

Description

technical field [0001] The present disclosure relates to a temperature-sensitive chitosan hydrogel composition and a bioink composition comprising the composition. Background technique [0002] 3D bioprinting is a 3D printing technology that arranges living cells in a desired structure and style to make tissues or organs. Currently skin, organ and bone transplants are mostly used through donation, but in the case of transplants, it is difficult to find compatible tissues or organs, and even transplants can cause many problems due to autoimmune reactions. In order to overcome these problems, researches on using biodegradable and biocompatible polymer materials to make various artificial substitutes, such as artificial bone, denture repair, artificial blood vessel, artificial Skin, artificial organs and biochips, etc. [0003] On the other hand, naturally derived polymers such as gelatin, chitosan, collagen, hyaluronic acid, and alginate are easy to process and shape, and ha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/52A61L27/20A61L27/22A61L27/56A61L27/38C12N5/00C09D11/04
CPCA61L27/20A61L27/26A61L27/52B29C64/106B33Y10/00B33Y70/00A61L2430/40C08L5/08C08L89/06A61L27/222A61L27/56A61L27/38C12N5/0068C09D11/04C12N2533/20C12N2533/54C12N2533/72C12N2533/10B33Y80/00A61L27/12A61L2430/34
Inventor 车美善金贞婤
Owner MEDIFAB CO LTD
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