Method for preparing lipidosome microcapsule long-acting mosquito repellent paste from plant essential oil

A plant essential oil and liposome technology, which is applied in the field of biomedicine, can solve the problems of poor heat sensitivity, poor mosquito repellent effect, easy volatilization of lemon eucalyptus essential oil, etc., and achieve the goal of preventing the volatilization of essential oil, good stability and prolonging mosquito repellent time Effect

Active Publication Date: 2021-07-02
GUANGXI FORESTRY RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides a method for preparing liposome microcapsules long-acting mosquito repellent ointment by using plant essential oils to solve the problems of easy volatilization, poor thermal sensitivity and poor mosquito repelling effect of essential oils of lemon eucalyptus oil and Java citronella oil

Method used

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  • Method for preparing lipidosome microcapsule long-acting mosquito repellent paste from plant essential oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A kind of method utilizing plant essential oil to prepare liposome microcapsule long-acting mosquito repellent ointment, comprises the steps:

[0030] S1: Dissolve p-menthane-3,8-diol and Java citronella oil in absolute ethanol at a mass ratio of 2:1, and then add sulfosuccinate castor oil with a mass ratio of 1:2 Carry out ultrasonic emulsification with Polyethylene Glycol (600) double laurate emulsifier, be made into core material system, the add-on of described emulsifier is 1.8% of Javanese citronella quality;

[0031] S2: Make a mixture of soybean lecithin, cholesterol, squash gum, propylene glycol alginate, and acrylate redispersible latex powder according to the mass ratio of 5:1:0.3:0.5:0.2, and then add the mixture to the core material system In, stir and mix evenly, the mass ratio of described mixture and core material is 1:1, the mixture that forms adopts decompression distillation to remove ethanol again, can obtain liposome film;

[0032] S3: Ultrasonic di...

Embodiment 2

[0034] A kind of method utilizing plant essential oil to prepare liposome microcapsule long-acting mosquito repellent ointment, comprises the steps:

[0035] S1: Dissolve p-menthane-3,8-diol and Java citronella oil in absolute ethanol at a mass ratio of 2:1, and then add sulfosuccinate castor oil with a mass ratio of 1:1 Carry out ultrasonic emulsification with polyethylene glycol (600) double laurate emulsifier, be made into core material system, the add-on of described emulsifier is 2.5% of Javanese citronella quality;

[0036] S2: Soybean lecithin, cholesterol, squash gum, propylene glycol alginate, ethylene-vinyl acetate redispersible latex powder are formulated into a mixture according to the mass ratio of 8:1.5:0.5:1:0.2, and then the mixture is added to In the core material system, stir and mix evenly, the mass ratio of the mixture and the core material is 1:1.2, and the formed mixture is then decompressed to remove ethanol to obtain the liposome membrane;

[0037] S3:...

Embodiment 3

[0039] A kind of method utilizing plant essential oil to prepare liposome microcapsule long-acting mosquito repellent ointment, comprises the steps:

[0040]S1: Dissolve p-menthane-3,8-diol and Javanese citronella oil in absolute ethanol at a mass ratio of 2:1, and then add sulfosuccinate castor oil with a mass ratio of 1:3 Carry out ultrasonic emulsification with Polyethylene Glycol (600) double laurate emulsifier, be made into core material system, the add-on of described emulsifier is 1.2% of Javanese citronella quality;

[0041] S2: Soybean lecithin, cholesterol, squash gum, propylene glycol alginate, and ethylene-vinyl acetate redispersible latex powder are made into a mixture according to the mass ratio of 10:2:0.1:0.6:0.3, and then the mixture is added to In the core material system, stirring and mixing are uniform, the mass ratio of the mixture and the core material is 1:1.5, stirring and mixing are uniform, and the formed mixture is then decompressed to remove ethanol...

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Abstract

The invention discloses a method for preparing lipidosome microcapsule long-acting mosquito repellent paste from plant essential oil, which comprises the following steps: uniformly mixing p-menthane-3, 8-diol yellow oily matter and Cymbopogon winterianus oil according to a mass ratio of 2: 1,dissolving in absolute ethyl alcohol, and then adding sulfonated succinate castor oil and a polyethylene glycol (600) dilaurate emulsifier for ultrasonic emulsification to prepare a core material system; stirring soybean lecithin, cholesterol, sesbania gum, propylene glycol alginate and redispersible latex powder into a core material system, uniformly stirring, and removing a solvent to obtain a liposome membrane; and ultrasonically dispersing the liposome membrane into a PBS buffer solution system containing polyvinylpyrrolidone, filtering, collecting filtrate, and freeze-drying to form the mosquito repellent paste. Themosquito repellent paste prepared by the method has a good mosquito-repelling effect, has double effects of moistening skin, can well prevent essential oil from volatilizing, and has no toxic or side effect on human and environment; and the used materials and process can better meet the requirements of environmental protection and health.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a method for preparing liposome microcapsule long-acting mosquito repellent ointment by using plant essential oil. Background technique [0002] The main components of lemon eucalyptus oil are citronellal, neoisopulegol, isopulegol, citronellol, citronellyl acetate, and β-caryophyllene; Java citronella oil mainly contains citronellal, citronella Leaf alcohol, β-citronellol and elemol and other ingredients have good analgesic, antispasmodic, antibacterial, and antioxidant capabilities. Most of the water phase in the lemon eucalyptus extraction process is directly discharged into the environment, and has not been rationally developed and utilized, resulting in a waste of resources. There is a certain content in it, and it has a good mosquito repellent effect, and has no toxic and side effects on people and the environment. [0003] Javanese Citronella Oil Contains Citronellal...

Claims

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Application Information

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IPC IPC(8): A01N65/44A01N31/06A01N25/28A01P17/00
CPCA01N65/44A01N31/06A01N25/28A01N65/00Y02A50/30
Inventor 谷瑶杨漓李桂珍
Owner GUANGXI FORESTRY RES INST
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