Unlock instant, AI-driven research and patent intelligence for your innovation.

Gynecological temperature-sensitive gel and preparation method thereof

A temperature-sensitive gel, gynecological technology, applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc. Reduce irritation and injury, promote wound healing, high comfort

Pending Publication Date: 2021-07-09
GUIZHOU YANGSHENG MEDICAL INSTR
View PDF9 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some current pharmaceutical preparations cannot fully meet the clinical and market needs in terms of curative effect. Although some chemicals have anti-inflammatory and antibacterial effects, they do not take into account the skin irritation problem.
Currently, chitosan is the main product used in gynecological inflammation or postoperative repair. The main dosage forms include suppositories, gels, powders, liquids, etc. The products have antibacterial and repairing effects, but these products have weak antibacterial properties. The therapeutic effect is not obvious, and it may even destroy the acid-base balance of the female reproductive system, causing pollution to the female reproductive tract
The raw materials of some commonly used flushing solutions include traditional Chinese medicine and disinfectants, which are easy to contaminate the patient's clothes during use, and it is inconvenient to clean after contamination

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Gynecological temperature-sensitive gel and preparation method thereof
  • Gynecological temperature-sensitive gel and preparation method thereof
  • Gynecological temperature-sensitive gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] This embodiment provides a thermosensitive gel for gynecology, including the following raw materials in parts by weight: 0.1 part of hypochlorite; 0.01 part of pH regulator; 0.01 part of carbomer; 0.01 part of poloxamer; 100 parts of water. Wherein, sodium hypochlorite is used as the hypochlorite, and hydrochloric acid is used as the pH regulator.

[0028] According to the parts by weight of the above-mentioned raw materials, the preparation method of the thermosensitive gel for gynecology in this embodiment comprises the following steps:

[0029] Step 1: At room temperature, add 0.1% sodium hypochlorite to 60 parts of water for dissolution, then add hydrochloric acid to adjust the pH value of the solution to 3 to obtain solution 1.

[0030] Step 2: At 4°C, add 0.02% to 0.2% of carbomer to the remaining water, stir continuously until it dissolves, then add 0.05% to 2% of poloxamer 407 for stirring, after stirring evenly, in 4 ℃ for 6 hours until the solution becomes cl...

Embodiment 2

[0033] This embodiment provides a thermosensitive gel for gynecology, including the following raw materials in parts by weight: 0.5 part of hypochlorite; 0.4 part of pH regulator; 0.3 part of carbomer; 0.45 part of poloxamer; 0.01 part of glycyrrhizic acid; 100 parts of water. Wherein, calcium hypochlorite is used as hypochlorite, and phosphoric acid is used as pH regulator.

[0034] According to the parts by weight of the above-mentioned raw materials, the preparation method of the thermosensitive gel for gynecology in this embodiment comprises the following steps:

[0035] Step 1: Add 0.1% calcium hypochlorite to 65 parts of water to dissolve at room temperature, then add phosphoric acid to adjust the pH value of the solution to 4.5 to obtain Solution 1.

[0036] Step 2: At 2°C, add 0.02% to 0.2% carbomer to the remaining water, stir continuously until it dissolves, then add 0.05% to 2% poloxamer 407 and glycyrrhizic acid for stirring, and stir evenly , placed at 2° C. for...

Embodiment 3

[0039] This embodiment provides a thermosensitive gel for gynecology, including the following raw materials in parts by weight: 0.75 parts of hypochlorite; 0.6 parts of pH regulator; 0.4 parts of carbomer; 0.6 part of poloxamer; 0.01 part of glucooligosaccharide ; 100 parts of water. Wherein, hypochlorite adopts sodium hypochlorite and potassium hypochlorite, and the add-on of sodium hypochlorite, potassium hypochlorite is respectively 0.45 part, 0.3 part, and pH adjusting agent adopts hydrochloric acid and phosphoric acid, and the add-on of hydrochloric acid, phosphoric acid is respectively 0.3 part, 0.3 part.

[0040] According to the parts by weight of the above-mentioned raw materials, the preparation method of the thermosensitive gel for gynecology in this embodiment comprises the following steps:

[0041] Step 1: Add 0.1% sodium hypochlorite and potassium hypochlorite to 65 parts of water for dissolution at room temperature, then add hydrochloric acid and phosphoric acid...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a gynecological temperature-sensitive gel and a preparation method thereof, and relates to the technical field of gynecological medication. The raw materials for preparing the temperature-sensitive gel comprise pypocholoride, a pH regulator, carbomer, poloxamer and water; the method for preparing the temperature-sensitive gel comprises the following steps: adding pypocholoride into a proper amount of water for dissolving, then adding the pH regulator, adjusting the pH value of the solution to 3-6 to obtain a solution I; adding carbomer into residual water, performing stirring until the carbomer is dissolved, then adding poloxamer, performing uniform stirring, performing standing until the solution is clear to obtain a solution II, finally slowly adding the solution I into the solution II, and slowly performing stirring until the solution I and the solution II are uniformly mixed. The temperature-sensitive gel provided by the invention is non-toxic and non-irritant, and has the advantages of good bactericidal performance, long acting time and high comfort level.

Description

technical field [0001] The invention relates to the technical field of gynecological medicine, in particular to a thermosensitive gel for gynecology and a preparation method thereof. Background technique [0002] Gynecological inflammation has become a common and frequently-occurring disease in women. Its clinical manifestations are various, the etiology is complex, and it is often accompanied by a variety of serious complications, which has a great impact on women's life and work. Some current pharmaceutical preparations cannot fully meet the clinical and market needs in terms of curative effect. Although some chemicals have anti-inflammatory and antibacterial effects, they do not take into account the skin irritation problem. Currently, chitosan is the main product used in gynecological inflammation or postoperative repair. The main dosage forms include suppositories, gels, powders, liquids, etc. The products have antibacterial and repairing effects, but these products hav...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K33/20A61K31/77A61K31/78A61K47/10A61K9/06A61P15/00A61P15/02A61P31/04A61P31/10A61K31/704A61K31/702
CPCA61K33/20A61K31/77A61K31/78A61K31/704A61K31/702A61K47/10A61K9/06A61K9/0034A61P15/00A61P15/02A61P31/04A61P31/10A61K2300/00
Inventor 黄昌平郑茂鑫田静杜伟民姚其秀邓晓梅吴丹张娅
Owner GUIZHOU YANGSHENG MEDICAL INSTR