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Collagenase inhibitor, moisturizing crystal dew containing collagenase inhibitor and preparation method of moisturizing crystal dew

A collagenase and inhibitor technology, applied in the field of cosmetics, can solve the problems of large molecular weight of hydrolyzed collagen and difficult to reach the dermis, and achieve the effects of excellent inhibitory effect, easy raw materials and simple operation.

Pending Publication Date: 2021-07-13
GUANGZHOU KENENG COSMETICS RES CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In view of the existing technology, the molecular weight of hydrolyzed collagen is too large, and it is difficult to penetrate the skin barrier of the human body to reach the dermis; hyaluronic acid cannot essentially slow down the loss of collagen; peptides and retinol have certain irritation and safety risks to the skin etc., the present invention firstly provides a collagenase inhibitor and a preparation method thereof

Method used

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  • Collagenase inhibitor, moisturizing crystal dew containing collagenase inhibitor and preparation method of moisturizing crystal dew
  • Collagenase inhibitor, moisturizing crystal dew containing collagenase inhibitor and preparation method of moisturizing crystal dew
  • Collagenase inhibitor, moisturizing crystal dew containing collagenase inhibitor and preparation method of moisturizing crystal dew

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preparation example Construction

[0042] The preparation method of the collagenase inhibitor of the present invention is not particularly limited, and may be a common method in the art, specifically including the step of mixing the components of the collagenase inhibitor. For example, the Dendrobium officinale extract and the chamomile extract are uniformly mixed in a conventional mixing manner.

[0043] Collagenase

[0044] Collagenase belongs to a class of matrix metalloproteinases (Matrix Metalloproteinase, MMPs). Matrix metalloproteinases are a family of endopeptidases whose biological activity depends on zinc ions and has the ability to degrade extracellular matrix (Extra-Cellar Matrix, ECM). The main function of collagenase is to degrade collagen and elastin in the dermis, and its tissue inhibitors (Tissue Inhibitors of Metalloproteinase, TIMPs) specifically inhibit the activity of collagenase by covalently binding to its highly conserved zinc binding site , jointly regulate matrix metabolism and maint...

Embodiment

[0087] Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention. Those who do not indicate the specific conditions in the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all commercially available conventional products.

[0088] Chamomile extract was purchased from: Quzhou Zhanhong Biotechnology Co., Ltd.

[0089] Dendrobium officinale extract was purchased from: Quzhou Zhanhong Biotechnology Co., Ltd.

Embodiment 1-5

[0095] Dendrobium officinale extract and chamomile extract are provided as collagenase inhibitors. Dendrobium candidum extract and chamomile extract are in mass ratio 3:1 (embodiment 1), 2:1 (embodiment 2), 1:1 (embodiment 3), 1:2 (embodiment 4), 1:1 3 (Example 5) After mixing, a collagenase inhibitor was obtained.

[0096] The collagenase inhibitor of Example 1 was dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0097] The collagenase inhibitors of Example 2 were dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0098] The collagenase inhibitor of Example 3 was dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0099] The collagenase inhibitor of Example 4 was dissolved in 5 groups of deionized water respectively to obtain 5 groups of test solutions. mL.

[0100] The collagenase inhibitor of Example 5 was dissolved in 5 groups...

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Abstract

The invention provides a collagenase inhibitor, a moisturizing crystal dew containing the collagenase inhibitor and a preparation method of the moisturizing crystal dew. The collagenase inhibitor comprises a dendrobium officinale extract and a chamomile extract, and based on the total mass of the collagenase inhibitor, the addition amount of the dendrobium officinale extract is 17-65%, and the addition amount of the chamomile extract is 35-83%. The collagenase inhibitor of the present invention has an excellent inhibitory effect on the activity of collagenase, and has no side effects on the human body.

Description

technical field [0001] The invention relates to a collagenase inhibitor, moisturizing crystal dew containing the collagenase inhibitor and a preparation method thereof, belonging to the field of cosmetics. Background technique [0002] Collagen is mainly produced by fibroblasts in the dermis and is the main component of the dermis. It can maintain the structure of the skin and give the skin toughness and elasticity. The content and distribution of collagen determine the youthfulness of the skin. However, the abnormal reduction of collagen content will cause the thinning of the dermis, loose skin, loss of elasticity, and wrinkles, which will affect people's quality of life. With the deepening of research on collagen, researchers have found that collagenase plays an important role in the homeostasis of skin collagen, and its overexpression and abnormal activation are one of the main causes of skin aging. Therefore, inhibiting the activity of collagenase can block the degrada...

Claims

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Application Information

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IPC IPC(8): A61K8/9794A61K8/9789A61K8/34A61K8/37A61K8/73A61Q19/08A61Q19/00
CPCA61K8/9794A61K8/9789A61K8/345A61K8/37A61K8/73A61Q19/08A61Q19/00A61K2800/782A61K2800/5922A61K2800/592
Inventor 谢佩佩杨登亮李传茂张楚标曾伟丹张伟杰
Owner GUANGZHOU KENENG COSMETICS RES CO LTD
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