Tightening cream, preparation method thereof and collagenase inhibitor

A technology of collagenase and inhibitor, which is applied in the field of firming cream and its preparation method and collagenase inhibitor, can solve problems such as difficulty, and achieve the effect of simple operation, excellent inhibitory effect, and easy raw materials

Pending Publication Date: 2021-07-16
GUANGZHOU KENENG COSMETICS RES CO LTD +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, the molecular weight of hydrolyzed collagen is too large, and it is difficult to penetrate the skin barrier of the human body to reach the dermis; hyaluronic acid cannot essentially slow down the loss of collagen; peptides and retinol have certain irritation and safety risks to the skin, etc.

Method used

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  • Tightening cream, preparation method thereof and collagenase inhibitor
  • Tightening cream, preparation method thereof and collagenase inhibitor
  • Tightening cream, preparation method thereof and collagenase inhibitor

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0043]The preparation method of the collagenase inhibitor of the present invention is not particularly limited, and it can be a common method in the field, for example, a mixing method is used to uniformly mix the pomegranate peel extract and grapefruit extract.

[0044] Collagenase

[0045] Collagenase belongs to a class of matrix metalloproteinases (Matrix Metalloproteinase, MMPs). Matrix metalloproteinases are a family of endopeptidases whose biological activity depends on zinc ions and has the ability to degrade extracellular matrix (Extra-Cellar Matrix, ECM). The main function of collagenase is to degrade collagen and elastin in the dermis, and its tissue inhibitors (Tissue Inhibitors of Metalloproteinase, TIMPs) specifically inhibit the activity of collagenase by covalently binding to its highly conserved zinc binding site , jointly regulate matrix metabolism and maintain the structure of the dermis.

[0046] Collagenases include mesenchymal collagenase (MMP-1), poly...

Embodiment

[0092] Embodiments of the present invention will be described in detail below in conjunction with examples, but those skilled in the art will understand that the following examples are only used to illustrate the present invention, and should not be considered as limiting the scope of the present invention. Those who do not indicate the specific conditions in the examples are carried out according to the conventional conditions or the conditions suggested by the manufacturer. The reagents or instruments used were not indicated by the manufacturer, and they were all commercially available conventional products.

[0093] Red pomegranate peel extract: Quzhou Zhanhong Biotechnology Co., Ltd.;

[0094] Grapefruit extract: Quzhou Zhanhong Biotechnology Co., Ltd.

Embodiment 1-5

[0100] Provides pomegranate peel extract and grapefruit extract as collagenase inhibitors. Red pomegranate peel extract and grapefruit extract are by mass ratio 3:1 (embodiment 1), 2:1 (embodiment 2), 1:1 (embodiment 3), 1:2 (embodiment 4), After mixing 1:3 (Example 5), the collagenase inhibitor was obtained. The collagenase inhibitors of Examples 1-5 were respectively dissolved in 5 groups of deionized water corresponding to the volumes of Comparative Examples 1-5. Examples 1-5 can obtain 5 groups of test solutions corresponding to the concentrations of Comparative Examples 1-5. Wherein, among the collagenase inhibitors, the contents (mass %) of pomegranate peel extract and grapefruit extract are shown in Table 1 below, and the logarithmic mass concentration of collagenase inhibitors is shown in Table 3 below.

[0101] Table 1

[0102]

[0103] Inhibition of Collagenase Activity Test

[0104] Folin's phenol reagent can be reduced by phenolic compounds under alkaline ...

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PUM

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Abstract

The invention provides a tightening cream, a preparation method thereof and a collagenase inhibitor. The tightening cream comprises the collagenase inhibitor and a penetration enhancer, based on the total mass of the tightening cream, the addition amount of the collagenase inhibitor is 0.01-10%, and the addition amount of the penetration enhancer is 0.01-10%; the collagenase inhibitor comprises a red pomegranate bark extract and a grapefruit extract, and based on the total mass of the collagenase inhibitor, the addition amount of the red pomegranate bark extract is 15-65%, and the addition amount of the grapefruit extract is 35-85%. The tightening cream disclosed by the invention is mild in formula, and can effectively improve skin elasticity, so that an anti-aging effect is achieved.

Description

technical field [0001] The invention relates to a firming cream, a preparation method thereof and a collagenase inhibitor, belonging to the field of cosmetics. Background technique [0002] Collagen is mainly produced by fibroblasts in the dermis and is the main component of the dermis. It can maintain the structure of the skin and give the skin toughness and elasticity. The content and distribution of collagen determine the youthfulness of the skin. However, the abnormal reduction of collagen content will cause the thinning of the dermis, loose skin, loss of elasticity, and wrinkles, which will affect people's quality of life. With the deepening of research on collagen, researchers have found that collagenase plays an important role in the homeostasis of skin collagen, and its overexpression and abnormal activation are one of the main causes of skin aging. Therefore, inhibiting the activity of collagenase can block the degradation of skin collagen, increase the content of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61Q19/00A61Q19/08
CPCA61K2800/5922A61K2800/782A61Q19/00A61Q19/08A61K8/9789
Inventor 杨登亮林盛杰李传茂邱桂芳张楚标曾伟丹张伟杰
Owner GUANGZHOU KENENG COSMETICS RES CO LTD
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