Cross-linked chitosan styptic powder and preparation method thereof

Abstract

The invention provides cross-linked chitosan styptic powder and a preparation method thereof, the liquid absorption amount of the cross-linked chitosan styptic powder is more than 30 times of the weight of the cross-linked chitosan styptic powder, and the cross-linked chitosan styptic powder is prepared by adopting the following method: adding a chitosan raw material into an organic solvent, stirring and swelling, then dropwise adding an acid solution in a stirring state, reacting for 0.5-2 hours, adding a cross-linking agent into the reaction liquid to carry out cross-linking reaction, and filtering, washing and drying after the reaction is finished, thereby obtaining the product. The cross-linked chitosan hemostatic powder provided by the invention has a good hemostatic effect on wounds with large bleeding amount, such as severe skin surface local bleeding or arterial bleeding under emergency conditions; according to the provided preparation method, chitosan does not need to be dissolved into a solution and then subjected to a cross-linking reaction, the original powdery substance form of chitosan is well reserved in the preparation process, the preparation process is simple, and the cost is low.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a chitosan hemostatic powder and a preparation method thereof. Background technique [0002] Hemorrhage is one of the causes of death in trauma patients, and rapid and effective control of hemorrhage can significantly reduce mortality. As a natural marine alkaline polysaccharide, chitosan has good biocompatibility, good hemostatic effect, and has the functions of promoting healing and antibacterial, so it is the first choice for hemostatic materials. Chitosan hemostatic powder does not rely on normal coagulation factors and acts independently. Its positively charged product particles cross-combine with negatively charged red blood cells to form blood clots. The coagulation process is a physical action without any adverse reactions. [0003] Chitosan hemostatic powder in the prior art, its composition mainly is chitosan, carboxymethyl chitosan, chitosan lactic acid...

AI Technical Summary

Problems solved by technology

This method needs to add a sufficient amount of cross-linking agent to make the cross-linked chitosan precipitate. When the cross-linking agent is added in a small amount, the formed cross-linked chitosan has a small degree of cross-linking and a high solubility in water, so it cannot be precipitated. It can be made into finished products by freeze-drying, and the cost is relatively high

This application has prepared cross-linked chitosan by adding a sufficient amount of cross-linking agent, but its cross-linking is too large, insoluble in water, and has poor hemostatic effect

[0006] The patent application with application number 2014107301353 discloses a chitosan hemostatic powder formed by covalent cross-linking and its preparation method, specifically: making chitosan into an aqueous solution, and then adding a cross-linking agent to the chitosan aqueous solution , fully stirred and mixed, then freeze-dried to obtain a sponge-like product, the preparation process is complicated and the cost is high

[0007] The above reactions are made of chitosan into a solution, and then a cross-linking agent is added to carry out the cross-linking reaction. Although the uniformity of the reaction is guaranteed, the preparation process is complicated, the cost is high, and the hemostatic effect of the product is also poor.

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