Hollow mesoporous organic silicon composite nanomaterial with reverse contrast magnetic resonance imaging and drug controlled release functions and preparation method of hollow mesoporous organic silicon composite nanomaterial

A composite nanomaterial and magnetic resonance imaging technology, which is applied in drug combinations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of reduced loading of anti-tumor drugs, cytotoxic side effects, and easy release and other issues, to achieve huge application transformation potential, high-efficiency chemotherapy effect, and slow-controlled release effect
CN113134096APending Publication Date: 2021-07-20SOUTHERN MEDICAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN ยท China
Current Assignee / Owner
SOUTHERN MEDICAL UNIVERSITY
Publication Date
2021-07-20

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Abstract

The invention discloses a hollow mesoporous organic silicon composite nanomaterial with reverse contrast magnetic resonance imaging and drug controlled release functions and a preparation method thereof. The hollow mesoporous organic silicon composite nanomaterial comprises hollow mesoporous organic silicon nanoparticles (HMON) and a drug and a magnetic resonance imaging (MRI) contrast agent, the drug is carried in a cavity of the HMON, and the MRI contrast agent is blocked in a pore channel of the HMON. The hollow mesoporous organic silicon composite nanomaterial can well avoid early release of chemotherapeutic drugs and further improve the drug loading rate. The hollow mesoporous organic silicon composite nano material induces biodegradation to release the medicine loaded in the cavity through GSH response in a tumor microenvironment, so that slow release and controlled release of the chemotherapeutic medicine in the tumor microenvironment are realized, and the toxic and side effects on normal tissue cells are very small while an ideal anti-tumor effect is fully played.
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Description

technical field

[0001] The invention relates to the technical field of biomedical materials, in particular to a hollow mesoporous organosilicon composite nanomaterial with functions of reverse contrast magnetic resonance imaging and drug controlled release and a preparation method thereof. Background technique

[0002] Tumor is a disease with high morbidity and mortality. Although various anti-tumor methods have been developed, chemotherapy is still the most widely used treatment for tumors. Conventional cancer chemotherapy usually leads to severe systemic toxicity under the action of highly toxic drugs, and at the same time, the efficacy of tumor drugs is also greatly reduced. In fact, strong toxic side effects and low chemotherapy effect have become one of the main causes of death of cancer patients. Therefore, the construction of an ideal drug-loading system must satisfy the ability to deliver therapeutic drugs during the systemic circulation without premature leakage, a...

Claims

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