Hollow mesoporous organic silicon composite nanomaterial with reverse contrast magnetic resonance imaging and drug controlled release functions and preparation method of hollow mesoporous organic silicon composite nanomaterial

A composite nanomaterial and magnetic resonance imaging technology, which is applied in drug combinations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problem of reduced loading of anti-tumor drugs, cytotoxic side effects, and easy release and other issues, to achieve huge application transformation potential, high-efficiency chemotherapy effect, and slow-controlled release effect

Pending Publication Date: 2021-07-20
SOUTHERN MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But at the same time, due to the existence of large cavities in HMON, most chemotherapeutic drugs cannot be stably loaded in HMON, and are easily eluted during the preparation pr

Method used

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  • Hollow mesoporous organic silicon composite nanomaterial with reverse contrast magnetic resonance imaging and drug controlled release functions and preparation method of hollow mesoporous organic silicon composite nanomaterial
  • Hollow mesoporous organic silicon composite nanomaterial with reverse contrast magnetic resonance imaging and drug controlled release functions and preparation method of hollow mesoporous organic silicon composite nanomaterial
  • Hollow mesoporous organic silicon composite nanomaterial with reverse contrast magnetic resonance imaging and drug controlled release functions and preparation method of hollow mesoporous organic silicon composite nanomaterial

Examples

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Example Embodiment

[0106] Example 1

[0107] The implementation provides a hollow diaphragm silicone composite nanomaterial, and HMON, which is comparable to the FEGD-HN comparative agent, to obtain HMON @ DOX @ FEGD-HN, then coupled to RGD2 polypeptides.

[0108] The specific preparation method of hollow media silicone composite nanomaterials includes the following steps:

[0109] (1) Preparation HMON

[0110] HMON the present invention is employed in accordance with the literature "Fan W, Lu N, Shen Z, et al.Generic synthesisof small-sized hollow mesoporous organosilica nanoparticles for oxygen-independent X-ray-activated synergistic therapy [J] .Nature communications, 2019, 10 (1): 1-14. "The method of the method disclosed in the preparation, the mesoporous template used is a hexadalkyltrimethylammonium chloride (CTAC), the silicone source is double - [3- (triethoxy) Silicon) propyl] - tetraside (Btes).

[0111] Specifically, 2 g of CTAC, 0.1 g of triethanolamine was dissolved in 20 ml of water, ...

Example Embodiment

[0172] Example 2

[0173] This implementation provides a hollow diaphragm silicone composite nanomaterial using FEGD-HN comparative agent HMON to block paclitaxel (Tax), to obtain HMON @ Tax @ FEGD-HN, and the specific preparation method is as follows:

[0174]The HMON2 solution (10.6 mg / ml) obtained by 0.2 ml of Example 1 was mixed with 0.4 ml of paclitaxel Tax solution (1.16 mg / ml) under ultrasound, and water retained the final total reaction solution volume of 1 mL, and stirring Tax loading, centrifugation, pure water was washed 5 times in 24 hours, and HMON2 @ Tax is collected; then it is dispersed to 1 ml C in ultrasound conditions. Gd 5mm, c Fe In a FEGD-HN solution of 10.2 mm, the magnetic stirring was then stirred for 3 hours, then the nanoparticles were centrifuged at 200,000 rpm to 50 minutes, and then washed 5 times with pure water, that is, the resulting FEGD-HN blocking hollow meshalon Composite nanoparticles (HMON2 @ Tax @ FEGD-HN3).

Example Embodiment

[0175] Example 3

[0176] This implementation provides a hollow diaphragm silicone composite nanofilm material, which is comparable to HMON, which is comparable to Cisplatin (DDP), which is obtained by HMON @ DDP @ FEGD-HN, and the specific preparation method is as follows:

[0177] The HMON2 solution (10.6 mg / ml) obtained by 0.2 ml of Example 1 was mixed with 0.4 ml of cisplatin DDP solution (1.16 mg / ml) under ultrasoundation conditions, and water retained the final total reaction solution volume of 1 mL, and protected from light. Stirring is filled with DDP, centrifugal, pure water was washed 5 times, and HMON2 @ Tax is collected, and then it is dispersed to 1 ml C. Gd 5mm, c Fe In a FEGD-HN solution of 10.2 mm, the magnetic stirring was then stirred for 3 hours, then the nanoparticles were centrifuged at 200,000 rpm to 50 minutes, and then washed 5 times with pure water, that is, the resulting FEGD-HN blocking hollow meshalon Drug control sustained release of nanoparticles ...

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Abstract

The invention discloses a hollow mesoporous organic silicon composite nanomaterial with reverse contrast magnetic resonance imaging and drug controlled release functions and a preparation method thereof. The hollow mesoporous organic silicon composite nanomaterial comprises hollow mesoporous organic silicon nanoparticles (HMON) and a drug and a magnetic resonance imaging (MRI) contrast agent, the drug is carried in a cavity of the HMON, and the MRI contrast agent is blocked in a pore channel of the HMON. The hollow mesoporous organic silicon composite nanomaterial can well avoid early release of chemotherapeutic drugs and further improve the drug loading rate. The hollow mesoporous organic silicon composite nano material induces biodegradation to release the medicine loaded in the cavity through GSH response in a tumor microenvironment, so that slow release and controlled release of the chemotherapeutic medicine in the tumor microenvironment are realized, and the toxic and side effects on normal tissue cells are very small while an ideal anti-tumor effect is fully played.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a hollow mesoporous organosilicon composite nanomaterial with functions of reverse contrast magnetic resonance imaging and drug controlled release and a preparation method thereof. Background technique [0002] Tumor is a disease with high morbidity and mortality. Although various anti-tumor methods have been developed, chemotherapy is still the most widely used treatment for tumors. Conventional cancer chemotherapy usually leads to severe systemic toxicity under the action of highly toxic drugs, and at the same time, the efficacy of tumor drugs is also greatly reduced. In fact, strong toxic side effects and low chemotherapy effect have become one of the main causes of death of cancer patients. Therefore, the construction of an ideal drug-loading system must satisfy the ability to deliver therapeutic drugs during the systemic circulation without premature leakage, a...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K47/64A61K45/00A61K51/08A61K51/12A61P35/00B82Y5/00B82Y25/00B82Y30/00B82Y40/00
CPCA61K47/6929A61K47/64A61K51/08A61K51/1251A61K45/00B82Y5/00B82Y25/00B82Y30/00B82Y40/00A61P35/00
Inventor 沈折玉黄林
Owner SOUTHERN MEDICAL UNIVERSITY
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