Chromatographic separation-free mass spectrometry system and method

A mass spectrometry and chromatographic separation technology, which is applied in the separation tube vacuum system, particle separator tube parts, particle separation tube, etc., to achieve the effect of improving analysis sensitivity, high analysis sensitivity, and improving ion passing rate

Pending Publication Date: 2021-07-23
HANGZHOU PUYU TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Ion mobility technology works under normal pressure or weak vacuum, and requires a certain drift gas to separate charged particles according to the difference in mobility; while mass spectrometry needs to work under high vacuum environment, these two technologies cannot be combined in the conventional field

Method used

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  • Chromatographic separation-free mass spectrometry system and method

Examples

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Effect test

Embodiment 1

[0033] figure 1 A schematic structural diagram of a mass spectrometry system without chromatographic separation is given in an embodiment of the present invention, as figure 1 As shown, the mass spectrometry system without chromatographic separation includes:

[0034] The ion source and the sampling cone, the first chamber and the second chamber arranged in sequence, the ion source is arranged in the ionization chamber, and the air pump communicates with the second chamber, so that the pressure in the second chamber is lower than that of the first chamber and the ionization chamber. room;

[0035] an ion mobility module, the ion mobility module is arranged in the first chamber; the first chamber has a gas inlet and a gas outlet, and the gas inlet is farther away from the sampling cone than the gas outlet, making the flow direction of the buffer gas entering the ion mobility module opposite to the ion movement direction;

[0036] An ion storage and ejection module, the ion s...

Embodiment 2

[0063] An application example of the mass spectrometry system and method without chromatographic separation according to Embodiment 1 of the present invention.

[0064] In this application example, if figure 1 As shown, the ion source adopts ESI and is set in the ionization chamber; the sampling cone, the first chamber, the third chamber and the second chamber are arranged in sequence, and the air pumps are respectively connected to the first chamber, the second chamber and the third chamber, so that the first chamber The pressure in the first chamber is lower than the ionization chamber, higher than the second chamber and the third chamber, and the pressure in the second chamber is the lowest; there is a partition between the first chamber and the third chamber, and the partition is provided with a structure suitable for ions to pass through the first through hole; the transmission rod is set in the third chamber, and the mass spectrometer is set in the second chamber;

[00...

Embodiment 3

[0076] According to the application example of the mass spectrometry system and method without chromatographic separation according to embodiment 1 of the present invention, the difference from embodiment 2 is:

[0077] 1. The first chamber is no longer evacuated, and the pressure is the same as that of the ionization chamber, which is atmospheric pressure; the first part is connected to the second chamber, and the second part is selectively connected to the first chamber and the third chamber through the switching module: when the second part When communicating with the third chamber, the first through hole communicates with the second through hole, and when the second part communicates with the first chamber, the second through hole and the first through hole are staggered, and the second sliding member blocks the spacer to realize The isolation between the first room and the third room is achieved, that is, the isolation between the first room and the second room is realized...

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Abstract

The invention provides a chromatographic separation-free mass spectrometry system and method. The chromatographic separation-free mass spectrometry system comprises an ion source, and a sampling cone, a first chamber and a second chamber which are arranged in sequence, and an air pump is communicated with the second chamber; the ion mobility module is arranged in the first chamber; the first chamber is provided with a gas inlet and a gas outlet, and compared with the gas outlet, the gas inlet is farther away from the sampling cone; the ion storage and push-out module is arranged in the first chamber and located between the sampling cone and the ion mobility module. The method has the advantages of high analysis efficiency, high sensitivity and the like.

Description

technical field [0001] The invention relates to mass spectrometry, in particular to a mass spectrometry analysis system and method without chromatographic separation. Background technique [0002] Chromatography-mass technology uses liquid / gas chromatography as the separation system and mass spectrometry as the detection system. The sample is separated from the mobile phase in the chromatographic part. After being ionized, the mass analyzer of the mass spectrometer separates the ion fragments according to their mass numbers. The detector obtains a mass spectrum. Chromatography-mass spectrometry reflects the complementary advantages of chromatography and mass spectrometry. It combines the high separation ability of chromatography for complex samples with the advantages of high selectivity, high sensitivity and the ability to provide relative molecular mass and structural information of MS. It is used in drug analysis, It is widely used in many fields such as food analysis an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/06H01J49/24H01J49/04H01J49/00
CPCH01J49/24H01J49/062H01J49/0495H01J49/0422H01J49/0031
Inventor 俞晓峰刘洋韩双来杨继伟尹伊君
Owner HANGZHOU PUYU TECH DEV CO LTD
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