Degradable stent for preventing and treating esophageal stenosis

A technology for esophageal stenosis and benign esophageal stenosis, which is applied in the field of degradable stents, can solve problems such as lack of mechanical properties, and achieve the effects of accelerating collagen degradation, reducing collagen synthesis, and increasing collagenase activity

Pending Publication Date: 2021-07-30
ZHONGSHAN HOSPITAL FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the special physical and chemical properties of collagen, it often does not have stable mechanical properties and is prone to short-term degradation after molding. Therefore, it is necessary to add a specific cross-linking agent to cross-link the free amino groups of chitosan and collagen to obtain a stable structure.

Method used

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  • Degradable stent for preventing and treating esophageal stenosis
  • Degradable stent for preventing and treating esophageal stenosis
  • Degradable stent for preventing and treating esophageal stenosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0083] 1. Establishment of an animal model of esophageal stricture after ESD

[0084] (1) Shanghai white pigs (15-20kg, male) were used, fasted for one day and then intubated for anesthesia. Endoscopic submucosal stripping of the esophageal mucosa 5 cm above the cardia was performed, with a longitudinal diameter of about 3 cm.

[0085] (2) Endoscopic observation of 3, 7, 14, 21, and 42 days after endoscopic esophageal circumferential ESD, recording the time of stenosis and lumen diameter. About 2-3 weeks after ESD, the esophageal stenosis was confirmed, and food residues were seen under the endoscope, and the stenotic pores were about 1-2 mm after cleaning.

[0086] 2. Degradable stent

[0087] (1) Compared with domestic and foreign material research and actual clinical needs, polylactic acid was selected as the main material of the degradable scaffold, and the scaffold was prepared by electrospinning weaving process.

[0088] (2) Combined with clinical needs and experimenta...

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Abstract

The invention relates to a degradable stent for preventing and treating esophageal stenosis, and belongs to the technical field of medical instruments. The degradable stent includes a film pasting material of genipin cross-linked chitosan collagen loaded with PLGA / triamcinolone acetonide sustained-release microspheres and a degradable stent, wherein a film pasting material of genipin cross-linked chitosan collagen loaded with PLGA (poly (lactic-co-glycolic acid)) and triamcinolone acetonide sustained-release microspheres is arranged on the periphery of the degradable stent. The degradable stent disclosed by the invention is mainly used for preventing and treating the benign stenosis of the esophagus, in particular to a series of benign stenosis problems such as postoperative wound surfaces of endoscopic submucosal dissection (ESD) for treating early esophageal cancer, postoperative anastomotic stoma stenosis of the thoracic surgery esophagus and scar contracture stenosis after esophageal chemical injury.

Description

technical field [0001] The invention relates to a degradable bracket for preventing and treating esophageal stenosis, which belongs to the technical field of medical devices. Background technique [0002] Esophageal cancer is a kind of digestive tract tumor with high incidence in my country. According to cancer statistics in 2015, the number of new cases of esophageal cancer in my country exceeds half of the total new cases in the world, and it is one of the top five deadly tumors in my country[1]. In recent years, thanks to NBI (narrow band imaging, narrow-band imaging) magnifying endoscopy technology and ESD (endoscopic submucosal dissection, endoscopic submucosal dissection) technology and the popularization of early cancer screening of the digestive tract, the early diagnosis and treatment of esophageal cancer in my country has achieved great success. made great progress. ESD is a technique for endoscopic early gastrointestinal cancer resection. It is safe and minimally ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/82A61F2/04
CPCA61F2/82A61F2/04A61F2002/821A61F2210/0004A61F2002/044
Inventor 林生力周平红倪温慨
Owner ZHONGSHAN HOSPITAL FUDAN UNIV
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