Application of Tibetan medicine composition in preparation of medicine for preventing and/or treating diabetic peripheral neuropathy

A technology for peripheral neuropathy and diabetes, which is applied in drug combinations, nervous system diseases, and medical raw materials derived from mammals, etc., can solve the problems of limited efficacy, high cost, and slow onset of effects of methylcobalamin

Pending Publication Date: 2021-07-30
TIBET QIZHENG TIBETAN MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional drugs still have many disadvantages, such as opioid analgesics, antidepressants and local anesthetics have a high rate of side effects and adverse reactions and are expensive, and methylcobalamin has limited or insufficient efficacy and slow onset of action
At present, there is no research report on the prevention and treatment of diabetic peripheral neuropathy with Baimai ointment or its related Tibetan medicine composition

Method used

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  • Application of Tibetan medicine composition in preparation of medicine for preventing and/or treating diabetic peripheral neuropathy
  • Application of Tibetan medicine composition in preparation of medicine for preventing and/or treating diabetic peripheral neuropathy
  • Application of Tibetan medicine composition in preparation of medicine for preventing and/or treating diabetic peripheral neuropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Embodiment 1 ointment

[0026] This embodiment provides a Tibetan medicine composition, the raw material formula is as follows: turmeric 36.3g, nutmeg 12.1g, nard pine 19.4g, actinolite 12.1g, licorice 17.0g, artificial musk 0.17g, dried ginger 24.2g, Tibetan fennel 31.5g, Tibetan calamus 17.0g, pepper 12.1g, alkali flower 18.2g.

[0027] The ointment of the above-mentioned Tibetan medicine composition, based on the total mass of 1000g, includes: turmeric 36.3g, nutmeg 12.1g, nard pine 19.4g, actinolite 12.1g, licorice 17.0g, artificial musk 0.17g, dried ginger 24.2g g, 31.5g of Tibetan fennel, 17.0g of Tibetan calamus, 12.1g of Zanthoxylum bungeanum, 18.2g of alkali flower, 80g of liquid paraffin, 80g of glycerin, 10g of polysorbate 80, 10g of methylparaben, and the balance is water.

[0028] Preparation method: Weigh turmeric, nutmeg, nard pine, actinolite, licorice, dried ginger, Tibetan fennel, Tibetan calamus, Zanthoxylum bungeanum and alkali flower according to t...

Embodiment 2

[0029] Embodiment 2 wet dressing

[0030] This embodiment provides a Tibetan medicine composition, the raw material formula is as follows: turmeric 30g, nutmeg 15g, nard pine 15g, actinolite 15g, licorice 15g, artificial musk 0.2g, dried ginger 20g, Tibetan fennel 35g, Tibetan calamus 15g, Zanthoxylum bungeanum 15g, Suihua 20g.

[0031] The wet compress of the above-mentioned Tibetan medicine composition, raw materials include: 36.3g of turmeric, 12.1g of nutmeg, 19.4g of nard pine, 12.1g of actinolite, 17.0g of licorice, 0.17g of artificial musk, 24.2g of dried ginger, 31.5g of Tibetan fennel g, Tibetan calamus 17.0g, Zanthoxylum bungeanum 12.1g, alkali flower 18.2g.

[0032] Preparation method: Take turmeric, nutmeg, nard pine, actinolite, licorice, artificial musk, dried ginger, Tibetan fennel, Tibetan calamus, Zanthoxylum bungeanum, and alkali flower according to the above formula, crush them into coarse powder, and mix; add an appropriate amount of 60vt % ethanol impreg...

Embodiment 3

[0033] Example 3 tablet

[0034] This embodiment provides a Tibetan medicine composition, the raw material formula is as follows: 40g of turmeric, 10g of nutmeg, 25g of nard pine, 10g of actinolite, 20g of licorice, 0.1g of artificial musk, 30g of dried ginger, 25g of Tibetan fennel, and 25g of Tibetan calamus 20g, pepper 10g, alkali flower 15g.

[0035] The tablet of the above-mentioned Tibetan medicine composition, the raw material formula includes: turmeric 40g, nutmeg 10g, nard pine 25g, actinolite 10g, licorice 20g, artificial musk 0.1g, dried ginger 30g, Tibetan fennel 25g, Tibetan calamus 20g, Chinese prickly ash 10g, 15g of alkali flower, 90g of starch, 5g of magnesium stearate.

[0036] Preparation method: Take turmeric, nutmeg, nard pine, actinolite, licorice, dried ginger, Tibetan fennel, Tibetan calamus, Chinese prickly ash, artificial musk and alkali flower according to the above formula, grind them into coarse powder, mix, add starch and mix, Make granules, add m...

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Abstract

The invention relates to the technical field of Tibetan medicine, in particular to application of a Tibetan medicine composition in preparation of a medicine for preventing and / or treating diabetic peripheral neuropathy, the Tibetan medicine composition comprises the following raw material medicines: turmeric, nutmeg, rhizoma nardostachyos, actinolite, liquorice, artificial musk, rhizoma zingiberis, caraway, rhizoma acori calami, pepper and soda. It is found for the first time that the Tibetan medicine composition can improve the sensitivity of nerve endings of diabetic peripheral nerve injury model mice, relieve hypoalgesia and limb numbness symptoms caused by diabetic peripheral nerve injury and improve the motor nerve conduction speed of the diabetic peripheral nerve injury model mice; therefore, the Tibetan medicine composition can prevent and / or treat diabetic peripheral nerve injury and prevent and / or treat diabetic peripheral neuropathy, and is a potential medicine for diabetic peripheral neuropathy.

Description

technical field [0001] The invention relates to the technical field of Tibetan medicine, in particular to the application of a Tibetan medicine composition in the preparation of medicines for preventing and / or treating diabetic peripheral neuropathy. Background technique [0002] Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia caused by multiple etiologies. Long-term carbohydrate, fat, and protein metabolic disorders caused by relatively insufficient insulin secretion or decreased sensitivity of target cells to insulin can cause multiple systemic disorders. Damage to the eyes, kidneys, nerves, heart, blood vessels and other tissues and organs will lead to chronic progressive lesions, functional decline and failure. Among them, diabetic neuropathy is a complication caused by long-term chronic high blood sugar damage to the nervous system, and its clinical incidence rate can reach 47%-91%. Diabetic neuropathy mainly includes diabetic ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/06A61K47/26A61P3/10A61P25/02A61K33/00A61K33/26A61K35/55
CPCA61K36/9066A61K36/185A61K36/84A61K33/26A61K36/484A61K35/55A61K36/9068A61K36/23A61K36/888A61K36/758A61K33/00A61K9/06A61K47/26A61P3/10A61P25/02A61K2300/00
Inventor 雷菊芳刘凯列陈维武陈伦举车向宜李峰刁习霞
Owner TIBET QIZHENG TIBETAN MEDICINE
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