Spinal cord injury repair material and preparation method of tissue engineering scaffold

A technology for tissue engineering scaffolds and spinal cord injuries, which is applied in the field of regenerative medicine, can solve the problems of short survival time of neural stem cells and grow in clusters, and achieve the effects of easy adjustment, prolonging survival time, and simple preparation

Active Publication Date: 2021-07-30
AFFILIATED HOSPITAL OF YOUJIANG MEDICAL UNIV FOR NATTIES +1
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  • Abstract
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Problems solved by technology

[0004] The technical problem to be solved by the present invention is: the existing materials for spinal cord injury repair have the problems of short survival time of neural stem cells and growth in clumps

Method used

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  • Spinal cord injury repair material and preparation method of tissue engineering scaffold
  • Spinal cord injury repair material and preparation method of tissue engineering scaffold
  • Spinal cord injury repair material and preparation method of tissue engineering scaffold

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Embodiment

[0040] Example: such as figure 1 As shown, a spinal cord injury repair material according to a preferred embodiment of the embodiment of the present invention includes the following components in parts by weight: 10-40 parts of water-soluble polymer material, 5-20 parts of spinal cord biomaterial, hydrogel 10 to 20 copies, 0 to 5 copies of medicine. The water-soluble polymer material is polycaprolactone (abbreviated as PCL), the spinal cord biological material is rat decellularized spinal cord, and the drug is WAY316606, which can promote neural stem cell differentiation and axon regeneration. The composition of the double cross-linked hydrogel includes water, methacryloyl gelatin (GeLMA), double bond-β-cyclodextrin, polyethylene glycol diacrylate (PEGDA) and photoinitiator (LAP), wherein Water: methacrylated gelatin (GeLMA): double bond-β-cyclodextrin: polyethylene glycol diacrylate (PEGDA): photoinitiator (LAP) ratio is 100 parts: 12 parts: 8 parts : 1 part: 0.1 part, irra...

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Abstract

The invention relates to the technical field of regenerative medicine, in particular to a spinal cord injury repair material and a preparation method of a tissue engineering scaffold. The spinal cord injury repair material is prepared from the following components in parts by weight: 10 to 40 parts of water-soluble polymer material, 5 to 20 parts of spinal cord biological material, 10 to 20 parts of hydrogel and 0 to 5 parts of medicine. According to the spinal cord injury repair material, the polycaprolactone with good water solubility is used as the high polymer material fiber, the polycaprolactone and a hydrogel material are easy to obtain as raw materials, the micron fiber forming ink prepared from the polycaprolactone is simple to prepare, a medicine for regulating and controlling the differentiation of neuronal stem cells can be loaded in situ, and the spinal cord removal cell biological material can provide a similar growth environment for the neural stem cells, so that the survival time of the neural stem cells is prolonged, the neural stem cells are guided and promoted to differentiate into the neuronal cells, and the prepared tissue engineering scaffold is relatively good in repeatability.

Description

technical field [0001] The invention relates to the technical field of regenerative medicine, in particular to a preparation method of a spinal cord injury repair material and a tissue engineering support. Background technique [0002] Spinal cord injury is a highly disabling disease, mostly caused by direct or indirect trauma, manifested as paraplegia, that is, sensory, motor and sphincter dysfunction below the injured segment and other clinical manifestations. It often brings a devastating blow to the life of the patient, and the spinal cord regeneration disorder makes it difficult to restore function and imposes a huge burden on individuals and society. [0003] The current prevention and treatment of spinal cord injury focuses on reducing secondary injury, shortening the course of the disease, reducing further expansion of the damaged area, creating a good microenvironment for axon regeneration, promoting axon growth or inhibiting the formation of glial scar. There are ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/52A61L27/22A61L27/36A61L27/54A61L27/20
CPCA61L27/18A61L27/54A61L27/3675A61L27/3604A61L27/52A61L27/3687A61L27/3691A61L27/222A61L27/20A61L2430/38C08L67/04
Inventor 刘佳唐毓金赵兴昌李凯王翀王立强杨成亮
Owner AFFILIATED HOSPITAL OF YOUJIANG MEDICAL UNIV FOR NATTIES
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