Spinal cord injury repair material and preparation method of tissue engineering scaffold
A tissue engineering scaffold, a technology for spinal cord injury, which is applied in the field of regenerative medicine, can solve the problems of short survival time of neural stem cells and grow into clusters, and achieves the effects of easy adjustment, simple preparation and settlement of clusters.
Active Publication Date: 2022-07-22
AFFILIATED HOSPITAL OF YOUJIANG MEDICAL UNIV FOR NATTIES +1
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Problems solved by technology
[0004] The technical problem to be solved by the present invention is: the existing materials for spinal cord injury repair have the problems of short survival time of neural stem cells and growth in clumps
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[0040] Example: as figure 1 As shown in the figure, a spinal cord injury repair material according to a preferred embodiment of the embodiment of the present invention includes the following components in parts by weight: 10-40 parts of polymer material, 5-20 parts of spinal cord biomaterial, and 10-20 parts of hydrogel. 20 servings, 0-5 servings of drugs. The polymer material is polycaprolactone (abbreviated as PCL), the spinal cord biomaterial is rat acellular spinal cord, and the drug is WAY316606, which can promote neural stem cell differentiation and axon regeneration. The components of the double cross-linked hydrogel include water, methacrylated gelatin (GeLMA), double bond-β-cyclodextrin, polyethylene glycol diacrylate (PEGDA) and photoinitiator (LAP), wherein Water: Methacrylated Gelatin (GeLMA): Double Bond-β-Cyclodextrin: Polyethylene Glycol Diacrylate (PEGDA): Photoinitiator (LAP) The ratio is 100 parts: 12 parts: 8 parts : 1 part: 0.1 part, irradiated with 300-4...
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Abstract
The invention relates to the technical field of regenerative medicine, in particular to a preparation method of a spinal cord injury repair material and a tissue engineering scaffold. The spinal cord injury repair material, in parts by weight, includes: 10-40 parts of polymer material, 5-20 parts of spinal cord biological material, 10-20 parts of hydrogel, and 0-5 parts of medicine. The spinal cord injury repair material of the present invention uses polycaprolactone as the polymer material fiber, and the polycaprolactone is as easy to obtain as the hydrogel material as the raw material. In situ loading of drugs that regulate the differentiation of neuronal stem cells, and demyelinated cell biomaterials can provide a similar growth environment for neural stem cells to prolong the survival time of neural stem cells, guide and promote neural stem cells to differentiate into neuronal cells, tissue engineering prepared Stent repeatability is good.
Description
technical field [0001] The invention relates to the technical field of regenerative medicine, in particular to a preparation method of a spinal cord injury repair material and a tissue engineering scaffold. Background technique [0002] Spinal cord injury is a highly disabling disease, mostly caused by direct or indirect trauma, and manifested as paraplegia, which is a series of clinical manifestations such as sensory, motor and sphincter dysfunction below the injured segment. It often brings a devastating blow to the patient's life, and spinal cord aplasia causes difficulty in functional recovery and imposes a huge burden on individuals and society. [0003] Current research on spinal cord injury prevention and treatment focuses on reducing secondary injury, shortening the course of disease, reducing the further expansion of the injured area, creating a good microenvironment for axonal regeneration, promoting axonal growth or inhibiting the formation of glial scars. There ...
Claims
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IPC IPC(8): A61L27/18A61L27/52A61L27/22A61L27/36A61L27/54A61L27/20
CPCA61L27/18A61L27/54A61L27/3675A61L27/3604A61L27/52A61L27/3687A61L27/3691A61L27/222A61L27/20A61L2430/38C08L67/04
Inventor 刘佳唐毓金赵兴昌李凯王翀王立强杨成亮
Owner AFFILIATED HOSPITAL OF YOUJIANG MEDICAL UNIV FOR NATTIES