Atorvastatin calcium tablet as well as preparation method and application thereof

A technology of atorvastatin calcium and tablet cores, which is applied in the field of medicine, can solve the problems of adverse reactions of alkaline stabilizers and disintegrants, and achieve the effect of less adverse reactions, reduced dosage, and simple process

Active Publication Date: 2021-08-10
HAINAN JINRUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Though above-mentioned technological means makes finished product atorvastatin calcium tablet reach relevant quality standard, the adding of a large amount of alkaline stabilizers and disintegrating agent easily causes untoward reaction in clinical application; good atorvastatin calcium tablets

Method used

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  • Atorvastatin calcium tablet as well as preparation method and application thereof
  • Atorvastatin calcium tablet as well as preparation method and application thereof

Examples

Experimental program
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Effect test

preparation example 1

[0025] Weigh hydroxyapatite, pass through a 30-mesh sieve, and place it in a chitosan solution with a mass fraction of 0.5% and a pH value of 6.50 for ultrasonic soaking for 24 hours, stirring continuously during the process; after soaking, centrifuge, dry, The hydroxyapatite coated with chitosan was prepared and set aside.

preparation example 2

[0027] Weigh hydroxyapatite, pass through a 30-mesh sieve, and place it in a chitosan solution with a mass fraction of 0.5% and a pH value of 6.50 for ultrasonic soaking for 36 hours. After soaking, centrifuge, filter, and dry to prepare the shell Polysaccharide-coated hydroxyapatite, for later use.

preparation example 3

[0029] Weigh hydroxyapatite, pass through a 30-mesh sieve, and place it in a chitosan solution with a mass fraction of 0.5% and a pH value of 6.50 for ultrasonic soaking for 48 hours. After soaking, centrifuge, filter, and dry to prepare the shelled Polysaccharide-coated hydroxyapatite, for later use.

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Abstract

The invention relates to the technical field of medical technologies, in particular to an atorvastatin calcium tablet and a preparation method and application thereof. The atorvastatin calcium tablet comprises a tablet core and a coating wrapping the tablet core, and the tablet core is prepared from, by weight, 10-60 parts of atorvastatin calcium; 15-30 parts of a protective agent; 80-120 parts of a filling agent; 4-8 parts of a disintegrating agent; 0.3-1 part of a lubricant; the protective agent is prepared from anhydrous calcium hydrogen phosphate and hydroxyapatite subjected to modification treatment. The atorvastatin calcium tablet disclosed by the invention has the advantages of good stability and high dissolution rate. The preparation method of the atorvastatin calcium tablet comprises the steps of pretreatment, material weighing, primary mixing, total mixing, tabletting and coating, and the tablet prepared through the preparation method is high in dissolution rate and stable in drug effect. The atorvastatin calcium tablet can be applied to capsules, and has the advantages of convenience in dosage adjustment and high practicability in clinical application.

Description

technical field [0001] The invention relates to the technical field of medical technology, in particular to an atorvastatin calcium tablet and a preparation method and application thereof. Background technique [0002] Atorvastatin calcium tablets are the second generation of statins, which are selective and competitive 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, and are mainly used clinically. For the treatment of hypercholesterolemia and coronary heart disease, it is a statin blood lipid regulating drug, and its lipid-lowering effect is higher than that of other HMG-CoA reductase inhibitors. [0003] Atorvastatin calcium tablets themselves are inactive, and the hydrolyzate after oral absorption competitively inhibits the rate-limiting enzyme hydroxymethylglutaryl-CoA reductase in the process of cholesterol synthesis in the body, reducing the synthesis of cholesterol and making low-density lipoproteins The synthesis of lipoprotein receptors increa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/30A61K31/40A61K47/02A61K47/36A61K47/69A61P9/12A61K9/48A61J3/06
CPCA61K31/40A61K9/2009A61K9/205A61K9/282A61J3/06A61P9/12A61K9/5084A61K47/6923
Inventor 吴金霞黄月娜王小芳
Owner HAINAN JINRUI PHARMA
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