Injectable skin filler and preparation method thereof

A technology of dermal fillers and dispersants, which is applied in the field of medical cosmetology, can solve the problems of cumbersome preparation process and achieve the effect of simplifying the preparation process

Pending Publication Date: 2021-08-10
CHANGCHUN SINOBIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The existing conventional emulsification method uses a relatively toxic emulsifier when preparing microparticles, so post-processing is required to remove it, and then the microparticles are

Method used

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  • Injectable skin filler and preparation method thereof
  • Injectable skin filler and preparation method thereof
  • Injectable skin filler and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0051] An injectable dermal filler, comprising the following raw materials in mass percentage: poly-L-lactic acid 35.6%, sodium hyaluronate 23.7%, mannitol 40.7%; the dermal filler is wrapped in poly-L-lactic acid by sodium hyaluronate and mannitol Particles formed on the surface of lactic acid.

[0052] The specific preparation method is as follows:

[0053] Step 1: Set the intrinsic viscosity to 0.9m 3 Sodium hyaluronate / kg is dissolved in water to prepare a sodium hyaluronate aqueous solution, wherein the mass percentage of sodium hyaluronate and water in the sodium hyaluronate aqueous solution is 1%. Add 10.3 g of mannitol into the sodium hyaluronate aqueous solution, and stir to dissolve to obtain the first mixed liquid; wherein the first mixed liquid is the water phase.

[0054] Step 2: Weigh 9 g of poly-L-lactic acid with an intrinsic viscosity of 1.5 dL / g, dissolve it in 100 mL of dichloromethane, and prepare a second mixed liquid; wherein the second mixed liquid is ...

Embodiment 2

[0061] An injectable dermal filler, comprising the following raw materials in mass percentage: 48.0% poly-L-lactic acid, 20.0% sodium hyaluronate, and 32.0% glycine; the dermal filler is made of sodium hyaluronate and glycine wrapped on the surface of poly-L-lactic acid formed particles.

[0062] The specific preparation method is as follows:

[0063] Step 1: Set the intrinsic viscosity to 2.1m 3 Sodium hyaluronate / kg is dissolved in water to prepare a sodium hyaluronate aqueous solution, wherein the mass percentage of sodium hyaluronate and water in the sodium hyaluronate aqueous solution is 0.5%. Add 4.0 g of glycine to the sodium hyaluronate aqueous solution, and stir to dissolve to obtain the first mixed solution; wherein the first mixed solution is the water phase.

[0064] Step 2: Weigh 6 g of poly-L-lactic acid with an intrinsic viscosity of 1.8 dL / g, dissolve it in 80 mL of chloroform, and prepare a second mixed liquid; wherein the second mixed liquid is an oil phase...

Embodiment 3

[0071] An injectable dermal filler, comprising the following raw materials in mass percentage: 5.3% polycaprolactone, 3.4% sodium hyaluronate, 3.2% alanine and 88.1% water; the dermal filler is made of polycaprolactone in Suspension formed in sodium hyaluronate and alanine.

[0072] The specific preparation method is as follows:

[0073] Step 1: Set the intrinsic viscosity to 2.6m 3 Sodium hyaluronate / kg is dissolved in water to prepare a sodium hyaluronate aqueous solution, wherein the mass percentage of sodium hyaluronate and water in the sodium hyaluronate aqueous solution is 0.8%. Add 5.4g of alanine into the sodium hyaluronate aqueous solution, and stir to dissolve to obtain the first mixed solution; wherein the first mixed solution is the water phase.

[0074] Step 2: Weigh 9 g of polycaprolactone with an intrinsic viscosity of 1.6 dL / g, dissolve it in 90 mL of dichloromethane, and prepare a second mixed liquid; wherein the second mixed liquid is an oil phase.

[0075...

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Abstract

The invention discloses an injectable skin filler and a preparation method thereof. The skin filler is prepared from the following raw materials in percentage by mass: a polyester material, sodium hyaluronate and a dispersing agent. According to the embodiment of the invention, sodium hyaluronate is used as an emulsifier to prepare the skin filler; sodium hyaluronate in the skin filler not only can play roles in filling dermis tissues and keeping skin moisture, but also can be used as a suspending agent of particles. Compared with the existing technology for preparing the particles by adopting an emulsification method, the preparation method disclosed by the embodiment of the invention can realize synchronous preparation of the particles and the skin filler, and the preparation process is simplified.

Description

technical field [0001] The invention relates to the technical field of medical cosmetology, in particular to an injectable dermal filler and a preparation method thereof. Background technique [0002] Injection of soft tissue fillers is a minimally invasive treatment for filling skin wrinkles and depressions. The soft tissue fillers that appear on the market mainly include cross-linked sodium hyaluronate gel, collagen, polylactic acid, and calcium hydroxyapatite. Among them, the action time of cross-linked sodium hyaluronate gel and collagen in the skin is 6 to 12 months, and the action time of polylactic acid and calcium hydroxyapatite in the skin is about 2 years or more. [0003] Polyester materials, such as polylactic acid and polycaprolactone, have good biocompatibility, anticoagulation, non-toxicity and low immunity, so they are widely used in the fields of biomedicine and tissue engineering. Research in the past 30 years has shown that polyester materials and their m...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/20A61L27/60A61L27/50
CPCA61L27/18A61L27/20A61L27/60A61L27/50A61L2400/06C08L5/08C08L67/04
Inventor 王晓梅崔立国石旭东崔毅庄秀丽
Owner CHANGCHUN SINOBIOMATERIALS
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