Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Porous metal implant containing artificial bone meal and preparation method of porous metal implant

A technology for porous metal and implants, which is applied in the fields of prosthesis, tissue regeneration, medical science, etc., can solve the problems of difficult to achieve bone ingrowth, undisclosed organic combination, and long ingrowth time for porous implants. Achieve the effect of inducing ingrowth, excellent bone bearing, and good inducing ingrowth

Inactive Publication Date: 2021-08-10
湖南华锐科技集团股份有限公司
View PDF8 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although the design of the porous structure can better guide the ingrowth of autologous bone tissue to achieve bone fusion, but in larger defects or deeper defects, the time for bone-guided ingrowth is relatively long, and only porous implants are used. rapid bone ingrowth
In addition, artificial bone microparticles can realize osteoinductive ingrowth and self-fusion, but the prior art does not disclose how to realize the organic combination of the two matrix materials, so as to jointly solve the technical problems of bone defect and repair

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Porous metal implant containing artificial bone meal and preparation method of porous metal implant
  • Porous metal implant containing artificial bone meal and preparation method of porous metal implant
  • Porous metal implant containing artificial bone meal and preparation method of porous metal implant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) A 0.1% hyaluronic acid solution is prepared with a phosphate buffer solution; the hyaluronic acid has a molecular weight of 1 million Daltons.

[0027] (2) Disperse the artificial bone powder (allogeneic bone) in the hyaluronic acid solution, and undergo homogenization treatment to form a hyaluronic acid gel in which the artificial bone powder is uniformly dispersed; the homogenization treatment is performed under an ultrasonic vibration environment Stirring by a homogenizer; the particle size range of the artificial bone powder is 20um-100um.

[0028] (3) Submerge the porous metal implant in the hyaluronic acid gel evenly dispersed with artificial bone powder, and give the hyaluronic acid gel a pressure of 5 atmospheres while keeping the gel agitated to promote the coagulation of the hyaluronic acid. The glue fully fills the pores in the porous metal implant.

[0029] (4) Take out the porous metal implant fully filled with hyaluronic acid gel, and remove the water...

Embodiment 2

[0032] (1) Use 0.9% sodium chloride solution to prepare a 0.5% hyaluronic acid solution. The hyaluronic acid has a molecular weight of 1.5 million Daltons.

[0033] (2) Disperse the artificial bone powder (bovine inorganic bone powder) in the hyaluronic acid solution, and after homogenization treatment, form the hyaluronic acid gel in which the artificial bone powder is evenly dispersed; Stir with a quality machine; the particle size range of the artificial bone powder is 20um-100um.

[0034] (3) Submerge the porous metal implant in the hyaluronic acid gel B uniformly dispersed with artificial bone powder, and give the hyaluronic acid gel a pressure of 10 atmospheres while keeping the gel agitated to promote the hyaluronic acid The gel fully fills the pores in the porous metal implant.

[0035] (4) Take out the porous metal implant fully filled with hyaluronic acid gel, and remove the water molecules in the hyaluronic acid gel in the porous metal implant through drying proce...

Embodiment 3

[0038] (1) Prepare a 0.02% hyaluronic acid solution with water. The hyaluronic acid has a molecular weight of 200,000 Daltons.

[0039] (2) Disperse the artificial bone powder (hydroxyapatite powder) in the hyaluronic acid solution, and undergo homogenization treatment to form a hyaluronic acid gel in which the artificial bone powder is uniformly dispersed, and the homogenization treatment is performed in an ultrasonic vibration environment Stir with a homogenizer, and the particle size range of the artificial bone powder is 20um-100um.

[0040] (3) Submerge the porous metal implant in the hyaluronic acid gel evenly dispersed with artificial bone powder, and give the hyaluronic acid gel a pressure of 2 atmospheres while keeping the gel agitated to promote the coagulation of the hyaluronic acid. The glue fully fills the pores in the porous metal implant.

[0041] (4) Take out the porous metal implant fully filled with hyaluronic acid gel, and go through the freeze-drying proc...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
molecular weightaaaaaaaaaa
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention relates to the technical field of surgical implant materials, in particular to a porous metal implant containing artificial bone meal and a preparation method of the porous metal implant. The preparation method comprises the following steps: dissolving hyaluronic acid in a solvent I to obtain a hyaluronic acid solution with the concentration of 0.01-0.1%; dispersing artificial bone powder into the hyaluronic acid solution, and performing homogenization treatment to obtain hyaluronic acid gel; immersing the porous metal implant in the hyaluronic acid gel, giving 2-20 atmospheric pressures to the hyaluronic acid gel, and performing stirring treatment to obtain the porous metal implant containing the hyaluronic acid gel; and subjectingthe porous metal implant containing the hyaluronic acid gel to drying and irradiation sterilization treatment so as to obtain the porous metal implant containing the artificial bone meal. Artificial bone powder is introduced into pores of the porous metal implant, so that bone induction ingrowth and fusion autogenization can be realized more quickly, and the porous metal skeleton can exert excellent bone bearing and bone guiding characteristics of the porous metal skeleton.

Description

technical field [0001] The invention relates to the technical field of surgical implant materials, in particular to a porous metal implant containing artificial bone powder and a preparation method thereof. Background technique [0002] With the mature application of additive manufacturing technology in the development process of medical device products, porous metal implants such as porous titanium alloy implants, porous tantalum implants, etc. It plays the role of bone filling, bone conduction, and load bearing conduction in diseases such as bone defects and repairs such as trauma and trauma. [0003] Although the design of the porous structure can better guide the ingrowth of autologous bone tissue to achieve bone fusion, but in larger defects or deeper defects, the time for bone-guided ingrowth is relatively long, and only porous implants are used. It is difficult to achieve rapid bone ingrowth with implants. In addition, the artificial bone microparticles can realize ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/04A61L27/12A61L27/20A61L27/56
CPCA61L27/3608A61L27/365A61L27/20A61L27/12A61L27/04A61L27/56A61L2430/02C08L5/08
Inventor 宋坤刘江
Owner 湖南华锐科技集团股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com