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A kind of injectable bone cement containing disulfide bond and its preparation method

A bone cement and disulfide bond technology, applied in the field of bone cement, can solve problems such as difficult hydrolysis or enzymatic hydrolysis, unfavorable tissue reconstruction, etc., to achieve the effects of promoting adhesion, benefiting bone repair, and reducing injection pressure

Active Publication Date: 2018-08-07
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Moreover, the chain segments of polyethylene glycol are connected by stable ether bonds, which are difficult to be hydrolyzed or enzymatically hydrolyzed in vivo, and can only be eliminated through physiological metabolism by using its water solubility, which is not conducive to bone ingrowth and tissue reconstruction.

Method used

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  • A kind of injectable bone cement containing disulfide bond and its preparation method

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preparation example Construction

[0116] 2. A preparation method of the injectable bone cement containing disulfide bonds, comprising the following steps

[0117] Step a: Preparation of solidified liquid: dissolving polymercapto reagent in water, aqueous solution, or mixed solvent compatible with water, pH>5, preferably medium pH value or pH greater than 7;

[0118] Step b: blending and curing: blending the bone cement powder and the curing solution at a liquid-solid ratio of 0.1 to 10 mL:g to obtain the injectable bone cement containing disulfide bonds;

[0119] The bone cement powder contains inorganic calcium salt and acidic reagent, or the pH will be lowered during the curing process.

[0120] 2.1 Preparation of component (I) solid powder

[0121] Conventional preparation methods of inorganic calcium salts are well known to those skilled in the art and will not be repeated here. Taking calcium phosphate as an example, amorphous raw materials are usually prepared, and then sintered to obtain the desired c...

Embodiment 1

[0137] 1. Preparation of Bone Cement Powder

[0138] Calcium phosphate bone cement powder: Phosphorus-based calcium salt bone cement powder composed of β-tricalcium phosphate / tetracalcium phosphate in a molar ratio of 2:1.

[0139] 2. Preparation of Curing Solution

[0140] Polycysteine ​​with a molecular weight of 1 kDa was dissolved in a pH7.2 phosphate buffer with a mass concentration of 20%.

[0141] 3. Harmonize and solidify

[0142] At room temperature, mix 0.5g of bone cement powder and solidification solution according to the liquid-solid ratio of 0.5mL / g, mix it into a paste with a stirring pad, put it into a 1mL disposable syringe, and push it manually for injection. The injection time is about 3 minutes , The curing time is about 12min. Test according to standard ASTM C191.

[0143] Cured at room temperature for 24 hours, the cured product is immersed in water, and it will not collapse within 1 day.

[0144] Weigh 1g of bone cement powder, adjust according to t...

Embodiment 2

[0146] 1. Preparation of Bone Cement Powder

[0147] Calcium phosphate bone cement powder: Phosphorus-based calcium salt bone cement powder composed of β-tricalcium phosphate / tetracalcium phosphate in a molar ratio of 2:1. Add 6% alginic acid by vortex shaking blending method.

[0148] 2. Preparation of Curing Solution

[0149] Polycysteine ​​with a molecular weight of 2 kDa was dissolved in a pH7.2 phosphate buffer with a mass concentration of 10%.

[0150] 3. Harmonize and solidify

[0151] At room temperature, mix 0.5g of bone cement powder and solidification solution according to the liquid-solid ratio of 0.5mL / g, use a stirring pad to blend into a paste, put it into a 1mL disposable syringe, and manually push the injection. The injection time is about 6 minutes , The curing time is about 25min. Test according to standard ASTM C191.

[0152] Cured at room temperature for 24 hours, the cured product is immersed in water, and it will not collapse within 1 day.

[0153]...

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Abstract

The invention discloses disulfide bond containing injectable bone cement and a preparation method thereof. Solid powder of the disulfide bond containing injectable bone cement contains inorganic calcium salt and also contains an acidic reagent, or the pH can be reduced in the curing process; a curing liquid contains a multi-mercapto reagent, the pH is larger than 5, and the disulfide bond containing injectable bone cement is obtained after blending in the liquid-solid ratio being 0.1-10 mL:g. The disulfide bond containing injectable bone cement can establish a crosslinking network with self-repairing performance through disulfide bonds, and good injection performance can be well reserved while the mechanical strength and the anti-washout performance are improved, so that the product has good overall performance. The crosslinking network has excellent biocompatibility and biodegradability, facilitates adhesion, growth and multiplication of cells, facilitates bone repair and realizes ingrowth of the cells and blood vessels and reestablishing of bone tissue.

Description

technical field [0001] The invention relates to the field of bone cement, in particular to an injectable bone cement containing a disulfide bond and a preparation method thereof. Background technique [0002] Bone cement can be molded arbitrarily at the natural temperature and internal environment of the human body, solidifies by itself, and has no obvious exothermic effect, and can eventually be converted into a substance close to the inorganic components of human bone tissue. It has good biocompatibility and high safety, and can be used It is degraded in the liquid phase of the body and absorbed by bone tissue. [0003] The plasticity of the bone cement material makes it popular in the field of injection materials. The material can be directly injected into the bone defect and solidified quickly. It does not need to be plasticized in advance and can be implanted minimally. The trauma surface is small and many other advantages. [0004] In view of the fact that most inorg...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/04A61L27/12A61L27/18A61L27/20A61L27/50
CPCA61L27/047A61L27/12A61L27/18A61L27/20A61L27/50A61L2400/06A61L2430/02C08L77/04C08L5/08
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