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Cefquinome sulfate injectant and preparation method thereof

A technology of cefquinoxime sulfate and cefquinoxime, which is applied in directions such as pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc., can solve the problems of easy precipitation, poor dispersibility, etc. Guaranteed uniformity and good redispersibility

Pending Publication Date: 2021-08-13
河南健恒动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to: provide a kind of cefquinoxime sulfate injection and preparation method thereof, aim to solve the problems such as easy precipitation, delamination, poor dispersibility of cefquinome sulfate injection existing in the prior art

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Sterilize each raw material in advance;

[0028] (2) Mix corn oil and ethyl lactate with a volume ratio of 4:1 to obtain a 10000mL mixed system;

[0029] (3) Add 30g suspending agent Span 80 and 15g soybean lecithin, 55g antioxidant 2,6-di-tert-butyl-4-methylphenol into the mixing system, stir and mix evenly;

[0030] (4) add cefquinome sulfate micropowder 170g again in mixing system, grind to 200-300 order in colloid mill, obtain cefquinome sulfate injection;

[0031] (5) Filling, capping and steam sterilization of cefquinome sulfate injection.

Embodiment 2

[0033] (1) Sterilize each raw material in advance;

[0034] (2) Mix corn oil and ethyl lactate with a volume ratio of 2:1 to obtain a 10000mL mixed system;

[0035] (3) Add 45g suspending agent Span 80 and 15g soybean lecithin, 50g antioxidant 2,6-di-tert-butyl-4-methylphenol into the mixing system, stir and mix evenly;

[0036] (4) add cefquinome sulfate micropowder 180g again in mixing system, grind to 200-300 order in colloid mill, obtain cefquinome sulfate injection;

[0037] (5) Filling, capping and steam sterilization of cefquinome sulfate injection.

Embodiment 3

[0039] (1) Sterilize each raw material in advance;

[0040] (2) Mix corn oil and ethyl lactate with a volume ratio of 5:1 to obtain a 10000mL mixed system;

[0041] (3) Add 30g suspending agent Span 80 and 15g soybean lecithin, 60g antioxidant 2,6-di-tert-butyl-4-methylphenol into the mixing system, stir and mix evenly;

[0042] (4) add cefquinome sulfate micropowder 170g again in mixing system, grind to 200-300 order in colloid mill, obtain cefquinome sulfate injection;

[0043] (5) Filling, capping and steam sterilization of cefquinome sulfate injection.

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PUM

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Abstract

The invention discloses a cefquinome sulfate injectant and a preparation method thereof. The cefquinome sulfate injectant comprises 150-300 g of cefquinome sulfate micro powder, 30-100 g of a suspending aid, 50-80 g of an antioxidant and lipid or an ester organic solvent added to 10000 mL, wherein the mass of the cefquinome sulfate micro powder is calculated according to the mass of cefquinome. The cefquinome sulfate injectant is stable in content, the uniformity can be guaranteed for a long time, and the medicine effect can be fully exerted.

Description

technical field [0001] The invention belongs to the technical field of veterinary drug preparations, and in particular relates to a cefquinome sulfate injection and a preparation method thereof. Background technique [0002] my country's animal husbandry industry is mainly the breeding of food animals, so drug residues and cross-resistance with human drugs must be considered when using drugs. In view of this, the Ministry of Agriculture has very strict approval of veterinary antibacterial drugs, and actively promotes For veterinary medicine only. [0003] Cefquinome, also known as cefquinome or cefquinol, has been registered in my country and is a fourth-generation cephalosporin antibiotic for animals. Cefquinome achieves the bactericidal effect by inhibiting the synthesis of the cell wall. It has a broad antibacterial spectrum and strong antibacterial activity. Members of the genera Bacillus and Escherichia coli have low inhibitory concentrations and are also active agains...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/546A61K47/14A61K47/24A61K47/26A61K47/44A61P31/04
CPCA61K31/546A61K47/44A61K47/14A61K47/24A61K47/26A61K9/0019A61P31/04
Inventor 朱红标王申锋赵文刚
Owner 河南健恒动物药业有限公司
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