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A kind of anti-fatigue amphiphilic organic hydrogel and its preparation method and application

An amphiphilic, anti-fatigue technology, applied in prosthesis, medical science, etc., can solve problems such as water absorption swelling and poor mechanical properties, and achieve good anti-fatigue effect

Active Publication Date: 2022-04-12
GUANGZHOU INST OF BIOMEDICINE & HEALTH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The anti-fatigue amphiphilic hydrogel prepared by the preparation method of the present invention can solve the problems of water absorption swelling and poor mechanical properties of the current hydrogel

Method used

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  • A kind of anti-fatigue amphiphilic organic hydrogel and its preparation method and application
  • A kind of anti-fatigue amphiphilic organic hydrogel and its preparation method and application
  • A kind of anti-fatigue amphiphilic organic hydrogel and its preparation method and application

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] (1) Take 100 mg of PHA family polymer P3HB10U (poly 3-hydroxybutyrate-co-3-hydroxyundecylenic acid) (Beijing Blue Crystal Microbial Technology Co., Ltd., China) and add it to 3 mL of tetrahydrofuran solution, place in a circle shaped flask, stirred in a magnetic stirrer until completely dissolved;

[0049] (2) In the P3HB10U solution prepared in step (1), add 160 mg of 2000Da molecular weight HS-PEG-SH (dimercaptopolyethylene glycol) (Shanghai Aladdin Biochemical Technology Co., Ltd., China), at room temperature Stir under conditions until completely dissolved;

[0050] (3) 260 mg of PEGDA powder (polyethylene glycol (diol) diacrylate) (Sigma-Aldrich, U.S.) with a molecular weight of 10,000 Da was added to the solution obtained in step (2), and further mixed until completely dissolved ;

[0051] (4) Configure the graphdiyne nanoparticle dispersion, add 0.3 mg of graphdiyne powder (Nanjing Xianfeng Nano Material Technology Co., Ltd., China) to the solution obtained in ...

Embodiment 2

[0057] (1) Add 150mg of PHA family polymer P3HB10U into 4.5mL tetrahydrofuran solution, place in a round flask, and stir in a magnetic stirrer until completely dissolved;

[0058] (2) Add 240 mg of 2000 Da molecular weight HS-PEG-SH (dimercapto polyethylene glycol) to the P3HB10U solution prepared in step (1), and stir at room temperature until completely dissolved;

[0059] (3) Add 390 mg of PEGDA powder with a molecular weight of 10000 Da to the solution obtained in step (2), and further mix until completely dissolved;

[0060] (4) configure the graphyne nanoparticle dispersion liquid, add the graphyne powder of 0.45mg in the solution of step (3) gained, then add the SDS (sodium dodecyl sulfate) powder of 10mg, place in the ultrasonic disperser, Disperse at low temperature (5°C) for 1.2h until the graphdiyne powder is uniformly dispersed into nanoparticles in the solution;

[0061] (5) Place the solution obtained in step (4) under light-shielding conditions, add 30 mg of 2,...

Embodiment 3

[0065] (1) Add 120mg of PHA family polymer P3HB10U into 4mL THF solution, place in a round flask, and stir in a magnetic stirrer until completely dissolved;

[0066] (2) Add 200 mg of 2000 Da molecular weight HS-PEG-SH (dimercapto polyethylene glycol) to the P3HB10U solution prepared in step (1), and stir at room temperature until completely dissolved;

[0067] (3) Add 300 mg of PEGDA powder with a molecular weight of 10000 Da to the solution obtained in step (2), and further mix until completely dissolved;

[0068] (4) configure the graphyne nanoparticle dispersion liquid, add the graphyne powder of 0.4mg in the solution of step (3) gained, then add the SDS (sodium dodecyl sulfate) powder of 8mg, place in the ultrasonic disperser, Disperse for 1 hour at low temperature (10°C) until the graphdiyne powder is uniformly dispersed into nanoparticles in the solution;

[0069] (5) Place the solution obtained in step (4) under light-shielding conditions, add 30 mg of 2,2-dimethylolp...

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Abstract

The invention provides an anti-fatigue amphiphilic organic hydrogel and its preparation method and application. The preparation method comprises the following steps: (1) adding bis-mercapto polyethylene glycol to the double bond functionalized polyhydroxyalkanoate solution , after dissolving, add polyethylene glycol diacrylate, dissolve, obtain polymer solution; (2) add graphyne to the polymer solution that step (1) obtains, then add sodium lauryl sulfate, disperse, obtain dispersion; (3) adding 2,2-dimethylolpropionic acid and a photoinitiator to the dispersion in step (2), and curing by ultraviolet light to obtain the anti-fatigue amphiphilic organic hydrogel. The anti-fatigue amphiphilic hydrogel prepared by the preparation method of the invention can solve the problems of water absorption swelling and poor mechanical properties of the current hydrogel.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and relates to an anti-fatigue amphiphilic organic hydrogel, a preparation method and application thereof. Background technique [0002] Hydrogel is a kind of extremely hydrophilic three-dimensional network structure material, which has good biocompatibility, biodegradability, and structure similar to extracellular matrix. It has been widely used in the field of biomaterials and can be used as a tissue engineering scaffold for repairing tissue and organ regeneration. [0003] Although the preparation and application of hydrogel materials are relatively mature, ordinary hydrogels still have the following disadvantages: ①Under body fluid conditions, hydrogels are prone to swelling after absorbing water, resulting in decreased stability and easy breakage; ② The poor mechanical properties of hydrogels, especially prone to fatigue, lead to hydrogels prone to breakage during repeated stretching. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F299/02C08F299/04C08K3/04A61L27/08A61L27/18A61L27/52
CPCC08F299/028C08F299/0428C08F299/0485C08K3/04A61L27/52A61L27/08A61L27/18C08K2201/011
Inventor 巫林平侯金飞孙家明
Owner GUANGZHOU INST OF BIOMEDICINE & HEALTH CHINESE ACAD OF SCI