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MnSiO4/Yeast biological hybrid material as well as preparation method and application thereof

A biohybridization and silicon dioxide technology, applied in plant raw materials, plant/algae/fungi/moss components, nano-medicines, etc. Hybrid materials have poor treatment effects and other problems, achieving excellent tumor killing effects, overcoming poor targeting, and promoting chemical kinetic performance

Active Publication Date: 2021-08-24
ZHEJIANG UNIV HANGZHOU GLOBAL SCI & TECH INNOVATION CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the embodiment of the present application is to provide a kind of MnSiO 4 / Yeast biohybrid materials and their preparation methods and applications to solve the problems of poor therapeutic effect of biohybrid materials, poor therapeutic effect of single chemical kinetics, and poor targeting and specificity of nanoparticles

Method used

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  • MnSiO4/Yeast biological hybrid material as well as preparation method and application thereof
  • MnSiO4/Yeast biological hybrid material as well as preparation method and application thereof
  • MnSiO4/Yeast biological hybrid material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] This example provides a MnSiO 4 / Preparation of Yeast biohybrid materials, including:

[0044] In step (1), the silicon dioxide solution, disodium maleate and potassium permanganate are fully mixed to obtain a mixed solution;

[0045] Specifically, a silica solution is prepared first, and the silica can be prepared using traditional prepared by the method. Further, the specific steps include: weighing 1.4 g of ammonia solution, adding it to a mixed solution containing 30 mL of ethanol and 500 μL of water, and then adding 1.1 mL of TEOS dropwise into the above solution. After stirring at room temperature for 4 h, the SiO was collected by centrifugation at 12,000 rpm for 10 min. 2 Nanoparticles, washed several times with ethanol and water, and then dispersed in 100mL water to obtain a 0.6mg / mL silica solution;

[0046] Then take 10mL 0.6mg / mL silicon dioxide solution, 100mg disodium maleate and 37mg potassium permanganate and mix thoroughly to obtain a mixed solutio...

Embodiment 2

[0054] This example provides a MnSiO 4 / Preparation of Yeast biohybrid materials, including:

[0055] In step (1), the silicon dioxide solution, disodium maleate and potassium permanganate are fully mixed to obtain a mixed solution;

[0056] Specifically, a silica solution is prepared first, and the silica can be prepared using traditional prepared by the method. Further, the specific steps include: weighing 1.4 g of ammonia solution, adding it to a mixed solution containing 30 mL of ethanol and 500 μL of water, and then adding 1.2 mL of TEOS dropwise into the above solution. After stirring at room temperature for 4 h, the SiO was collected by centrifugation at 12,000 rpm for 10 min. 2 Nanoparticles, washed several times with ethanol and water, and then dispersed in 100mL water to obtain a 0.7mg / mL silica solution;

[0057] Then take 10mL 0.7mg / mL silicon dioxide solution, 100mg disodium maleate and 38mg potassium permanganate and mix thoroughly to obtain a mixed solutio...

Embodiment 3

[0065] This example provides a MnSiO 4 / Preparation of Yeast biohybrid materials, including:

[0066] In step (1), the silicon dioxide solution, disodium maleate and potassium permanganate are fully mixed to obtain a mixed solution;

[0067] Specifically, a silica solution is prepared first, and the silica can be prepared using traditional prepared by the method. Further, the specific steps include: weighing 1.4 g of ammonia solution, adding it to a mixed solution containing 30 mL of ethanol and 500 μL of water, and then adding 1.15 mL of TEOS dropwise into the above solution. After stirring at room temperature for 4 h, the SiO was collected by centrifugation at 12,000 rpm for 10 min. 2 Nanoparticles, washed several times with ethanol and water, and then dispersed in 100mL water to obtain a 0.65mg / mL silica solution;

[0068] Then take 10mL 0.65mg / mL silicon dioxide solution, 100mg disodium maleate and 37.4mg potassium permanganate and mix thoroughly to obtain a mixed so...

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Abstract

The invention discloses a MnSiO4 / Yeast biological hybrid material as well as a preparation method and the application thereof, and relates to the field of tumor treatment. The preparation method comprises the following steps: fully mixing a silicon dioxide solution, disodium maleate and potassium permanganate to obtain a mixed solution; transferring the mixed solution into a hydrothermal reaction kettle to obtain a manganese silicate vesicle solution; modifying the manganese silicate small vesicle solution by using polyetherimide; and adding the modified manganese silicate small vesicles into a yeast-containing solution, so as to obtain the MnSiO4 / Yeast biological hybrid particles. Based on the MnSiO4 / Yeaast (yeast) biological hybrid material, the synergistic treatment of self-enhanced chemical power and tumor immunity can be realized, and the problem that the tumor killing effect of a single way is relatively weak is solved. The MnSiO4 / Yeast nano-particles disclosed by the invention are simple in synthesis method and uniform in size; yeast can target a tumor slightly acidic environment and ferment to generate carbon dioxide to enhance MnSiO4 chemical power, and finally tumor synergistic killing is achieved.

Description

technical field [0001] The invention belongs to the field of biological hybrid materials, in particular to a kind of MnSiO 4 / Yeast biohybrid materials and their preparation methods and applications. Background technique [0002] In the past ten years, with the development of global society and economy, the acceleration of industrialization, the change of human living habits, the pollution of the global environment, and the aging of the population, malignant tumors have become one of the major diseases that seriously threaten human life. Malignant tumor, also known as cancer, refers to the abnormal proliferation of new organisms that appear in certain tissues under the action of many carcinogenic factors when the ability to regulate cell proliferation and growth is out of balance. According to the latest cancer data in China released by the National Cancer Center of my country in February 2017, about 7 people are diagnosed with cancer every minute in China, and the incidenc...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K47/59A61K33/32A61K36/064A61P35/00B82Y5/00
CPCA61K47/6901A61K47/59A61K33/32A61K36/064A61P35/00B82Y5/00A61K2300/00
Inventor 李翔胡泽峰傅译可
Owner ZHEJIANG UNIV HANGZHOU GLOBAL SCI & TECH INNOVATION CENT
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