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a kind of mnsio 4 /yeast biohybrid material and its preparation method and application

A bio-hybrid, silica technology, applied in plant raw materials, plant/algae/fungus/moss components, drug combinations, etc. The problem of poor effect of single chemodynamic therapy can achieve the effect of promoting chemical kinetic performance, overcoming poor targeting and excellent tumor killing effect.

Active Publication Date: 2022-05-03
ZHEJIANG UNIV HANGZHOU GLOBAL SCI & TECH INNOVATION CENT
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AI Technical Summary

Problems solved by technology

[0005] The purpose of the embodiment of the present application is to provide a kind of MnSiO 4 / Yeast biohybrid materials and their preparation methods and applications to solve the problems of poor therapeutic effect of biohybrid materials, poor therapeutic effect of single chemical kinetics, and poor targeting and specificity of nanoparticles

Method used

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  • a kind of mnsio <sub>4</sub> /yeast biohybrid material and its preparation method and application
  • a kind of mnsio <sub>4</sub> /yeast biohybrid material and its preparation method and application
  • a kind of mnsio <sub>4</sub> /yeast biohybrid material and its preparation method and application

Examples

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Effect test

Embodiment 1

[0043] This example provides a MnSiO 4 / Preparation of Yeast biohybrid materials, including:

[0044] In step (1), the silicon dioxide solution, disodium maleate and potassium permanganate are fully mixed to obtain a mixed solution;

[0045] Specifically, a silica solution is prepared first, and the silica can be prepared using traditional prepared by the method. Further, the specific steps include: weighing 1.4 g of ammonia solution, adding it to a mixed solution containing 30 mL of ethanol and 500 μL of water, and then adding 1.1 mL of TEOS dropwise into the above solution. After stirring at room temperature for 4 h, the SiO was collected by centrifugation at 12,000 rpm for 10 min. 2 Nanoparticles, washed several times with ethanol and water, and then dispersed in 100mL water to obtain a 0.6mg / mL silica solution;

[0046] Then take 10mL 0.6mg / mL silicon dioxide solution, 100mg disodium maleate and 37mg potassium permanganate and mix thoroughly to obtain a mixed solutio...

Embodiment 2

[0054] This example provides a MnSiO 4 / Preparation of Yeast biohybrid materials, including:

[0055] In step (1), the silicon dioxide solution, disodium maleate and potassium permanganate are fully mixed to obtain a mixed solution;

[0056] Specifically, a silica solution is prepared first, and the silica can be prepared using traditional prepared by the method. Further, the specific steps include: weighing 1.4 g of ammonia solution, adding it to a mixed solution containing 30 mL of ethanol and 500 μL of water, and then adding 1.2 mL of TEOS dropwise into the above solution. After stirring at room temperature for 4 h, the SiO was collected by centrifugation at 12,000 rpm for 10 min. 2 Nanoparticles, washed several times with ethanol and water, and then dispersed in 100mL water to obtain a 0.7mg / mL silica solution;

[0057] Then take 10mL 0.7mg / mL silicon dioxide solution, 100mg disodium maleate and 38mg potassium permanganate and mix thoroughly to obtain a mixed solutio...

Embodiment 3

[0065] This example provides a MnSiO 4 / Preparation of Yeast biohybrid materials, including:

[0066] In step (1), the silicon dioxide solution, disodium maleate and potassium permanganate are fully mixed to obtain a mixed solution;

[0067] Specifically, a silica solution is prepared first, and the silica can be prepared using traditional prepared by the method. Further, the specific steps include: weighing 1.4 g of ammonia solution, adding it to a mixed solution containing 30 mL of ethanol and 500 μL of water, and then adding 1.15 mL of TEOS dropwise into the above solution. After stirring at room temperature for 4 h, the SiO was collected by centrifugation at 12,000 rpm for 10 min. 2 Nanoparticles, washed several times with ethanol and water, and then dispersed in 100mL water to obtain a 0.65mg / mL silica solution;

[0068] Then take 10mL 0.65mg / mL silicon dioxide solution, 100mg disodium maleate and 37.4mg potassium permanganate and mix thoroughly to obtain a mixed so...

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Abstract

A kind of MnSiO of the present invention 4 / Yeast biohybrid material and its preparation method and application relate to the field of tumor treatment. The preparation method comprises: fully mixing silicon dioxide solution, disodium maleate and potassium permanganate to obtain a mixed solution; mixing the transfer the solution to a hydrothermal reaction kettle to obtain a manganese silicate vesicle solution; modify the manganese silicate vesicle solution with polyetherimide; add the modified manganese silicate vesicle into the yeast solution to obtain MnSiO 4 / Yeast biohybrid particles. Based on MnSiO 4 / Yeast (yeast) biohybrid material can realize self-enhanced chemical kinetics and tumor immune synergistic therapy, and solve the problem of weak tumor killing effect of a single approach. MnSiO in the present invention 4 / Yeast nanoparticle synthesis method is simple and uniform in size; yeast can target the slightly acidic environment of tumors and ferment to produce carbon dioxide to enhance MnSiO 4 Chemical kinetics, and finally realize the synergistic killing of tumors.

Description

technical field [0001] The invention belongs to the field of biological hybrid materials, in particular to a kind of MnSiO 4 / Yeast biohybrid materials and their preparation methods and applications. Background technique [0002] In the past ten years, with the development of global society and economy, the acceleration of industrialization, the change of human living habits, the pollution of the global environment, and the aging of the population, malignant tumors have become one of the major diseases that seriously threaten human life. Malignant tumor, also known as cancer, refers to the abnormal proliferation of new organisms that appear in certain tissues under the action of many carcinogenic factors when the ability to regulate cell proliferation and growth is out of balance. According to the latest cancer data in China released by the National Cancer Center of my country in February 2017, about 7 people are diagnosed with cancer every minute in China, and the incidenc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/69A61K47/59A61K33/32A61K36/064A61P35/00B82Y5/00
CPCA61K47/6901A61K47/59A61K33/32A61K36/064A61P35/00B82Y5/00A61K2300/00
Inventor 李翔胡泽峰傅译可
Owner ZHEJIANG UNIV HANGZHOU GLOBAL SCI & TECH INNOVATION CENT
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